DRC7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRC7_HUMAN
• UniProt AC: Q8IY82
• Protein Name: Dynein regulatory complex subunit 7
• Gene Name: DRC7
• Organism: Homo sapiens (Human).
• Sequence Length: 874
• Subcellular Localization: Cell projection, cilium, flagellum . Cytoplasm, cytoskeleton, cilium axoneme . Cytoplasm, cytoskeleton, flagellum axoneme . Associated with the outer doublet microtubules (OD).
• Protein Description: Component of the nexin-dynein regulatory complex (N-DRC) a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes. Involved in the regulation of flagellar motility..
• Protein Sequence: MEVLREKVEEEEEAEREEAAEWAEWARMEKMMRPVEVRKEEITLKQETLRDLEKKLSEIQITVSAELPAFTKDTIDISKLPISYKTNTPKEEHLLQVADNFSRQYSHLCPDRVPLFLHPLNECEVPKFVSTTLRPTLMPYPELYNWDSCAQFVSDFLTMVPLPDPLKPPSHLYSSTTVLKYQKGNCFDFSTLLCSMLIGSGYDAYCVNGYGSLDLCHMDLTREVCPLTVKPKETIKKEEKVLPKKYTIKPPRDLCSRFEQEQEVKKQQEIRAQEKKRLREEEERLMEAEKAKPDALHGLRVHSWVLVLSGKREVPENFFIDPFTGHSYSTQDEHFLGIESLWNHKNYWINMQDCWNCCKDLIFDLGDPVRWEYMLLGTDKSQLSLTEEDDSGINDEDDVENLGKEDEDKSFDMPHSWVEQIEISPEAFETRCPNGKKVIQYKRAKLEKWAPYLNSNGLVSRLTTYEDLQCTNILEIKEWYQNREDMLELKHINKTTDLKTDYFKPGHPQALRVHSYKSMQPEMDRVIEFYETARVDGLMKREETPRTMTEYYQGRPDFLSYRHASFGPRVKKLTLSSAESNPRPIVKITERFFRNPAKPAEEDVAERVFLVAEERIQLRYHCREDHITASKREFLRRTEVDSKGNKIIMTPDMCISFEVEPMEHTKKLLYQYEAMMHLKREEKLSRHQVWESELEVLEILKLREEEEAAHTLTISIYDTKRNEKSKEYREAMERMMHEEHLRQVETQLDYLAPFLAQLPPGEKLTCWQAVRLKDECLSDFKQRLINKANLIQARFEKETQELQKKQQWYQENQVTLTPEDEDLYLSYCSQAMFRIRILEQRLNRHKELAPLKYLALEEKLYKDPRLGELQKIFA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
83	Phosphorylation	DISKLPISYKTNTPK EHHHCCCEECCCCCC		24247654
84	Phosphorylation	ISKLPISYKTNTPKE HHHCCCEECCCCCCH		24247654
88	Phosphorylation	PISYKTNTPKEEHLL CCEECCCCCCHHHHH		24247654
515	Phosphorylation	PQALRVHSYKSMQPE CCHHECCCCCCCCCC		21214269
516	Phosphorylation	QALRVHSYKSMQPEM CHHECCCCCCCCCCH		21214269
551	Phosphorylation	TPRTMTEYYQGRPDF CCCCHHHHHCCCCCH		-
552	Phosphorylation	PRTMTEYYQGRPDFL CCCHHHHHCCCCCHH		-
561	Phosphorylation	GRPDFLSYRHASFGP CCCCHHHHHCCCCCC		-
576	Phosphorylation	RVKKLTLSSAESNPR CCEEEEECCCCCCCC		-
577	Phosphorylation	VKKLTLSSAESNPRP CEEEEECCCCCCCCC		-
638	Phosphorylation	KREFLRRTEVDSKGN HHHHHHHCCCCCCCC		22817900
642	Phosphorylation	LRRTEVDSKGNKIIM HHHCCCCCCCCEEEE		22817900
665	Phosphorylation	EVEPMEHTKKLLYQY EEECCHHHHHHHHHH		22817900
778	Phosphorylation	RLKDECLSDFKQRLI HCCHHHHHHHHHHHH		26657352

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of DRC7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of DRC7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRC7_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of DRC7_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.