dbPTM

BICC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	BICC1_HUMAN
UniProt AC	Q9H694
Protein Name	Protein bicaudal C homolog 1
Gene Name	BICC1
Organism	Homo sapiens (Human).
Sequence Length	974
Subcellular Localization	Cytoplasm.
Protein Description	Putative RNA-binding protein. Acts as a negative regulator of Wnt signaling. May be involved in regulating gene expression during embryonic development..
Protein Sequence	MAAQGEPGYLAAQSDPGSNSERSTDSPVPGSEDDLVAGATLHSPEWSEERFRVDRKKLEAMLQAAAEGKGRSGEDFFQKIMEETNTQIAWPSKLKIGAKSKKDPHIKVSGKKEDVKEAKEMIMSVLDTKSNRVTLKMDVSHTEHSHVIGKGGNNIKKVMEETGCHIHFPDSNRNNQAEKSNQVSIAGQPAGVESARVRIRELLPLVLMFELPIAGILQPVPDPNSPSIQHISQTYNISVSFKQRSRMYGATVIVRGSQNNTSAVKEGTAMLLEHLAGSLASAIPVSTQLDIAAQHHLFMMGRNGSNIKHIMQRTGAQIHFPDPSNPQKKSTVYLQGTIESVCLARQYLMGCLPLVLMFDMKEEIEVDPQFIAQLMEQLDVFISIKPKPKQPSKSVIVKSVERNALNMYEARKCLLGLESSGVTIATSPSPASCPAGLACPSLDILASAGLGLTGLGLLGPTTLSLNTSTTPNSLLNALNSSVSPLQSPSSGTPSPTLWAPPLANTSSATGFSAIPHLMIPSTAQATLTNILLSGVPTYGHTAPSPPPGLTPVDVHINSMQTEGKKISAALNGHAQSPDIKYGAISTSSLGEKVLSANHGDPSIQTSGSEQTSPKSSPTEGCNDAFVEVGMPRSPSHSGNAGDLKQMMCPSKVSCAKRQTVELLQGTKNSHLHSTDRLLSDPELSATESPLADKKAPGSERAAERAAAAQQNSERAHLAPRSSYVNMQAFDYEQKKLLATKAMLKKPVVTEVRTPTNTWSGLGFSKSMPAETIKELRRANHVSYKPTMTTTYEGSSMSLSRSNSREHLGGGSESDNWRDRNGIGPGSHSEFAASIGSPKRKQNKSTEHYLSSSNYMDCISSLTGSNGCNLNSSFKGSDLPELFSKLGLGKYTDVFQQQEIDLQTFLTLTDQDLKELGITTFGARRKMLLAISELNKNRRKLFESPNARTSFLEGGASGRLPRQYHSDIASVSGRW

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
18	Phosphorylation	AAQSDPGSNSERSTD ECCCCCCCCCCCCCC	42.44	28857561
20	Phosphorylation	QSDPGSNSERSTDSP CCCCCCCCCCCCCCC	35.76	28857561
23	Phosphorylation	PGSNSERSTDSPVPG CCCCCCCCCCCCCCC	32.30	23663014
24	Phosphorylation	GSNSERSTDSPVPGS CCCCCCCCCCCCCCC	46.87	23663014
26	Phosphorylation	NSERSTDSPVPGSED CCCCCCCCCCCCCHH	28.08	23663014
31	Phosphorylation	TDSPVPGSEDDLVAG CCCCCCCCHHHCCEE	31.61	-
43	Phosphorylation	VAGATLHSPEWSEER CEECEECCCCCCHHH	27.85	26425664
69	Ubiquitination	LQAAAEGKGRSGEDF HHHHHHCCCCCHHHH	42.53	29967540
124	Phosphorylation	EAKEMIMSVLDTKSN HHHHHHHHHHCCCCC	14.49	23403867
128	Phosphorylation	MIMSVLDTKSNRVTL HHHHHHCCCCCEEEE	32.01	23403867
134	Phosphorylation	DTKSNRVTLKMDVSH CCCCCEEEEEEECCC	19.88	28961369
150	Ubiquitination	EHSHVIGKGGNNIKK CCCCCCCCCCCHHHH	53.15	33845483
162	Phosphorylation	IKKVMEETGCHIHFP HHHHHHHHCCEEECC	31.63	22210691
180	Phosphorylation	RNNQAEKSNQVSIAG CCCCCHHHCCCEECC	24.81	22777824
184	Phosphorylation	AEKSNQVSIAGQPAG CHHHCCCEECCCCCC	9.28	22777824
194	Phosphorylation	GQPAGVESARVRIRE CCCCCHHHHHHHHHH	20.97	22777824
240	Phosphorylation	QTYNISVSFKQRSRM EEEEEEEEEEHHHHC	21.67	24719451
330	Phosphorylation	PSNPQKKSTVYLQGT CCCCCCCEEEEEECH	30.09	29038488
331	Phosphorylation	SNPQKKSTVYLQGTI CCCCCCEEEEEECHH	23.27	29038488
333	Phosphorylation	PQKKSTVYLQGTIES CCCCEEEEEECHHHH	8.06	29038488
337	Phosphorylation	STVYLQGTIESVCLA EEEEEECHHHHHHHH	14.49	21299198
340	Phosphorylation	YLQGTIESVCLARQY EEECHHHHHHHHHHH	17.80	21299198
394	O-linked_Glycosylation	KPKQPSKSVIVKSVE CCCCCCCCEEEEEHH	22.78	30379171
398	Ubiquitination	PSKSVIVKSVERNAL CCCCEEEEEHHHCCC	37.35	19608861
398	Acetylation	PSKSVIVKSVERNAL CCCCEEEEEHHHCCC	37.35	19608861
398	Malonylation	PSKSVIVKSVERNAL CCCCEEEEEHHHCCC	37.35	26320211
576	Phosphorylation	ALNGHAQSPDIKYGA HHCCCCCCCCCCCCE	25.89	26055452
586	Phosphorylation	IKYGAISTSSLGEKV CCCCEEECCHHCHHH	19.07	27251275
587	Phosphorylation	KYGAISTSSLGEKVL CCCEEECCHHCHHHH	19.44	26699800
588	Phosphorylation	YGAISTSSLGEKVLS CCEEECCHHCHHHHH	40.25	26699800
592	Ubiquitination	STSSLGEKVLSANHG ECCHHCHHHHHCCCC	46.83	29967540
602	Phosphorylation	SANHGDPSIQTSGSE HCCCCCCCCCCCCCC	31.88	27251275
605	Phosphorylation	HGDPSIQTSGSEQTS CCCCCCCCCCCCCCC	33.13	23663014
606	Phosphorylation	GDPSIQTSGSEQTSP CCCCCCCCCCCCCCC	24.77	22167270
608	Phosphorylation	PSIQTSGSEQTSPKS CCCCCCCCCCCCCCC	26.71	29255136
611	Phosphorylation	QTSGSEQTSPKSSPT CCCCCCCCCCCCCCC	42.83	29255136
612	Phosphorylation	TSGSEQTSPKSSPTE CCCCCCCCCCCCCCC	29.99	29255136
615	Phosphorylation	SEQTSPKSSPTEGCN CCCCCCCCCCCCCCC	44.96	29449344
616	Phosphorylation	EQTSPKSSPTEGCND CCCCCCCCCCCCCCC	41.80	28674419
618	Phosphorylation	TSPKSSPTEGCNDAF CCCCCCCCCCCCCCC	47.13	29449344
633	Phosphorylation	VEVGMPRSPSHSGNA EEECCCCCCCCCCCC	25.53	29255136
635	Phosphorylation	VGMPRSPSHSGNAGD ECCCCCCCCCCCCHH	31.37	29255136
637	Phosphorylation	MPRSPSHSGNAGDLK CCCCCCCCCCCHHHH	37.77	29255136
650	Phosphorylation	LKQMMCPSKVSCAKR HHHHCCCCHHHHHHH	40.54	29083192
653	Phosphorylation	MMCPSKVSCAKRQTV HCCCCHHHHHHHHHH	16.46	29083192
667	Ubiquitination	VELLQGTKNSHLHST HHHHHCCCCCCCCCH	64.38	29967540
669	Phosphorylation	LLQGTKNSHLHSTDR HHHCCCCCCCCCHHH	29.05	29514088
673	Phosphorylation	TKNSHLHSTDRLLSD CCCCCCCCHHHCCCC	38.06	29514088
674	Phosphorylation	KNSHLHSTDRLLSDP CCCCCCCHHHCCCCC	17.87	29514088
679	Phosphorylation	HSTDRLLSDPELSAT CCHHHCCCCCCCCCC	56.57	30266825
684	Phosphorylation	LLSDPELSATESPLA CCCCCCCCCCCCCCC	31.33	30266825
686	Phosphorylation	SDPELSATESPLADK CCCCCCCCCCCCCCC	33.35	23312004
688	Phosphorylation	PELSATESPLADKKA CCCCCCCCCCCCCCC	22.36	28674419
693	Ubiquitination	TESPLADKKAPGSER CCCCCCCCCCCCCHH	45.27	29967540
698	Phosphorylation	ADKKAPGSERAAERA CCCCCCCCHHHHHHH	23.89	23312004
721	Phosphorylation	RAHLAPRSSYVNMQA HHCCCCCCHHCCCCC	25.59	28857561
722	Phosphorylation	AHLAPRSSYVNMQAF HCCCCCCHHCCCCCC	34.09	28857561
723	Phosphorylation	HLAPRSSYVNMQAFD CCCCCCHHCCCCCCC	9.33	27642862
734	Ubiquitination	QAFDYEQKKLLATKA CCCCHHHHHHHHHHH	33.19	29967540
765	Ubiquitination	WSGLGFSKSMPAETI CCCCCCCCCCCHHHH	48.81	29967540
766	Phosphorylation	SGLGFSKSMPAETIK CCCCCCCCCCHHHHH	28.88	22617229
782	Phosphorylation	LRRANHVSYKPTMTT HHHCCCCCCCCCEEE	21.64	23312004
783	Phosphorylation	RRANHVSYKPTMTTT HHCCCCCCCCCEEEE	21.65	23312004
786	Phosphorylation	NHVSYKPTMTTTYEG CCCCCCCCEEEEECC	24.01	22210691
788	Phosphorylation	VSYKPTMTTTYEGSS CCCCCCEEEEECCCC	20.61	27732954
789	Phosphorylation	SYKPTMTTTYEGSSM CCCCCEEEEECCCCE	19.29	27732954
790	Phosphorylation	YKPTMTTTYEGSSMS CCCCEEEEECCCCEE	15.48	30576142
791	Phosphorylation	KPTMTTTYEGSSMSL CCCEEEEECCCCEEE	19.05	30576142
794	Phosphorylation	MTTTYEGSSMSLSRS EEEEECCCCEEECCC	15.78	28857561
795	Phosphorylation	TTTYEGSSMSLSRSN EEEECCCCEEECCCC	24.21	28857561
797	Phosphorylation	TYEGSSMSLSRSNSR EECCCCEEECCCCCC	25.74	30576142
799	Phosphorylation	EGSSMSLSRSNSREH CCCCEEECCCCCCCC	26.76	27422710
801	Phosphorylation	SSMSLSRSNSREHLG CCEEECCCCCCCCCC	35.46	23927012
803	Phosphorylation	MSLSRSNSREHLGGG EEECCCCCCCCCCCC	40.05	23927012
811	Phosphorylation	REHLGGGSESDNWRD CCCCCCCCCCCCCCC	36.88	23927012
813	Phosphorylation	HLGGGSESDNWRDRN CCCCCCCCCCCCCCC	37.63	23927012
826	Phosphorylation	RNGIGPGSHSEFAAS CCCCCCCCHHHHHHH	27.29	20068231
828	Phosphorylation	GIGPGSHSEFAASIG CCCCCCHHHHHHHCC	35.79	20068231
833	Phosphorylation	SHSEFAASIGSPKRK CHHHHHHHCCCCCCC	24.85	30266825
836	Phosphorylation	EFAASIGSPKRKQNK HHHHHCCCCCCCCCC	26.10	30266825
844	Phosphorylation	PKRKQNKSTEHYLSS CCCCCCCCCCHHHCC	46.72	23663014
845	Phosphorylation	KRKQNKSTEHYLSSS CCCCCCCCCHHHCCC	28.52	23663014
848	Phosphorylation	QNKSTEHYLSSSNYM CCCCCCHHHCCCCHH	11.31	23663014
850	Phosphorylation	KSTEHYLSSSNYMDC CCCCHHHCCCCHHHH	25.26	23663014
851	Phosphorylation	STEHYLSSSNYMDCI CCCHHHCCCCHHHHH	21.73	23663014
852	Phosphorylation	TEHYLSSSNYMDCIS CCHHHCCCCHHHHHH	28.71	23663014
854	Phosphorylation	HYLSSSNYMDCISSL HHHCCCCHHHHHHHH	9.04	23663014
859	Phosphorylation	SNYMDCISSLTGSNG CCHHHHHHHHHCCCC	26.15	23663014
871	Phosphorylation	SNGCNLNSSFKGSDL CCCCCCCCCCCCCCH	40.08	27251275
872	Phosphorylation	NGCNLNSSFKGSDLP CCCCCCCCCCCCCHH	29.88	27251275
883	Phosphorylation	SDLPELFSKLGLGKY CCHHHHHHHHCCCCC	39.33	24719451
931	Phosphorylation	RKMLLAISELNKNRR HHHHHHHHHHHHHHH	30.35	23403867
943	Phosphorylation	NRRKLFESPNARTSF HHHHHHCCCCHHHHH	19.00	21712546
948	Phosphorylation	FESPNARTSFLEGGA HCCCCHHHHHHCCCC	22.78	28857561
949	Phosphorylation	ESPNARTSFLEGGAS CCCCHHHHHHCCCCC	23.45	28857561
956	Phosphorylation	SFLEGGASGRLPRQY HHHCCCCCCCCCCCC	27.93	28857561
969	Phosphorylation	QYHSDIASVSGRW-- CCCCCCCCCCCCC--	19.70	28857561
971	Phosphorylation	HSDIASVSGRW---- CCCCCCCCCCC----	21.83	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of BICC1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of BICC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of BICC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of BICC1_HUMAN !!

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
601331	Renal dysplasia, cystic (CYSRD)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of BICC1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lysine acetylation targets protein complexes and co-regulates majorcellular functions."; Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.,Olsen J.V., Mann M.; Science 325:834-840(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-398, AND MASS SPECTROMETRY.	19608861 [Abstract]