SP5_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SP5_HUMAN
• UniProt AC: Q6BEB4
• Protein Name: Transcription factor Sp5
• Gene Name: SP5
• Organism: Homo sapiens (Human).
• Sequence Length: 398
• Subcellular Localization: Nucleus.
• Protein Description: Binds to GC boxes promoters elements. Probable transcriptional activator that has a role in the coordination of changes in transcription required to generate pattern in the developing embryo (By similarity)..
• Protein Sequence: MAAVAVLRNDSLQAFLQDRTPSASPDLGKHSPLALLAATCSRIGQPGAAAPPDFLQVPYDPALGSPSRLFHPWTADMPAHSPGALPPPHPSLGLTPQKTHLQPSFGAAHELPLTPPADPSYPYEFSPVKMLPSSMAALPASCAPAYVPYAAQAALPPGYSNLLPPPPPPPPPPTCRQLSPNPAPDDLPWWSIPQAGAGPGASGVPGSGLSGACAGAPHAPRFPASAAAAAAAAAALQRGLVLGPSDFAQYQSQIAALLQTKAPLAATARRCRRCRCPNCQAAGGAPEAEPGKKKQHVCHVPGCGKVYGKTSHLKAHLRWHTGERPFVCNWLFCGKSFTRSDELQRHLRTHTGEKRFACPECGKRFMRSDHLAKHVKTHQNKKLKVAEAGVKREDARDL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	VAVLRNDSLQAFLQD EEEECCHHHHHHHHC	26.40	23312004
20	Phosphorylation	QAFLQDRTPSASPDL HHHHHCCCCCCCCCC	29.86	23312004
22	Phosphorylation	FLQDRTPSASPDLGK HHHCCCCCCCCCCCC	40.54	23312004
24	Phosphorylation	QDRTPSASPDLGKHS HCCCCCCCCCCCCCC	24.24	29802988
31	Phosphorylation	SPDLGKHSPLALLAA CCCCCCCCHHHHHHH	25.70	23312004
39	Phosphorylation	PLALLAATCSRIGQP HHHHHHHHHHHHCCC	12.85	23312004
41	Phosphorylation	ALLAATCSRIGQPGA HHHHHHHHHHCCCCC	23.68	23312004
59	Phosphorylation	PDFLQVPYDPALGSP CCCCCCCCCCCCCCC	35.38	25999147
65	Phosphorylation	PYDPALGSPSRLFHP CCCCCCCCCCHHCCC	22.13	27050516
95	Phosphorylation	PHPSLGLTPQKTHLQ CCCCCCCCCCCCCCC	23.13	24719451
99	Phosphorylation	LGLTPQKTHLQPSFG CCCCCCCCCCCCCCC	23.67	23312004
104	Phosphorylation	QKTHLQPSFGAAHEL CCCCCCCCCCCCCCC	24.29	23312004
114	Phosphorylation	AAHELPLTPPADPSY CCCCCCCCCCCCCCC	25.86	23312004
120	Phosphorylation	LTPPADPSYPYEFSP CCCCCCCCCCCCCCC	39.01	23312004
121	Phosphorylation	TPPADPSYPYEFSPV CCCCCCCCCCCCCCC	18.41	23312004
123	Phosphorylation	PADPSYPYEFSPVKM CCCCCCCCCCCCCCC	22.75	23312004
126	Phosphorylation	PSYPYEFSPVKMLPS CCCCCCCCCCCCCCH	19.49	23312004
225	Phosphorylation	HAPRFPASAAAAAAA CCCCCCHHHHHHHHH	20.76	-
321	Phosphorylation	KAHLRWHTGERPFVC HHHHHHCCCCCCEEE	33.50	-
338	Phosphorylation	LFCGKSFTRSDELQR EEECCCCCCCHHHHH	36.03	26278961
340	Phosphorylation	CGKSFTRSDELQRHL ECCCCCCCHHHHHHH	32.17	29496963
349	Phosphorylation	ELQRHLRTHTGEKRF HHHHHHHHCCCCCCE	30.10	-
351	Phosphorylation	QRHLRTHTGEKRFAC HHHHHHCCCCCCEEC	46.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SP5_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SP5_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SP5_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SP5_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.