COX10_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: COX10_HUMAN
• UniProt AC: Q12887
• Protein Name: Protoheme IX farnesyltransferase, mitochondrial
• Gene Name: COX10
• Organism: Homo sapiens (Human).
• Sequence Length: 443
• Subcellular Localization: Mitochondrion membrane; Multi-pass membrane protein.
• Protein Description: Converts protoheme IX and farnesyl diphosphate to heme O..
• Protein Sequence: MAASPHTLSSRLLTGCVGGSVWYLERRTIQDSPHKFLHLLRNVNKQWITFQHFSFLKRMYVTQLNRSHNQQVRPKPEPVASPFLEKTSSGQAKAEIYEMRPLSPPSLSLSRKPNEKELIELEPDSVIEDSIDVGKETKEEKRWKEMKLQVYDLPGILARLSKIKLTALVVSTTAAGFALAPGPFDWPCFLLTSVGTGLASCAANSINQFFEVPFDSNMNRTKNRPLVRGQISPLLAVSFATCCAVPGVAILTLGVNPLTGALGLFNIFLYTCCYTPLKRISIANTWVGAVVGAIPPVMGWTAATGSLDAGAFLLGGILYSWQFPHFNALSWGLREDYSRGGYCMMSVTHPGLCRRVALRHCLALLVLSAAAPVLDITTWTFPIMALPINAYISYLGFRFYVDADRRSSRRLFFCSLWHLPLLLLLMLTCKRPSGGGDAGPPPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
10	Phosphorylation	ASPHTLSSRLLTGCV CCCCCHHHHHHHCCC	30.02	21815630
23	Phosphorylation	CVGGSVWYLERRTIQ CCCCCCHHEEEEECC	9.13	21815630
54	Phosphorylation	WITFQHFSFLKRMYV EEEHHHHHHHHHHHH	27.78	24719451
60	Phosphorylation	FSFLKRMYVTQLNRS HHHHHHHHHHHCCHH	12.36	25003641
62	Phosphorylation	FLKRMYVTQLNRSHN HHHHHHHHHCCHHCC	15.17	25003641
97	Phosphorylation	GQAKAEIYEMRPLSP CCCEEEEEECCCCCC	8.65	-
108	Phosphorylation	PLSPPSLSLSRKPNE CCCCCCCCCCCCCCH	28.74	24719451
110	Phosphorylation	SPPSLSLSRKPNEKE CCCCCCCCCCCCHHH	34.58	17081983
112	Ubiquitination	PSLSLSRKPNEKELI CCCCCCCCCCHHHCE	49.14	29967540
116	Ubiquitination	LSRKPNEKELIELEP CCCCCCHHHCEECCC	65.54	29967540
135	Ubiquitination	EDSIDVGKETKEEKR HHHCCCCCCCHHHHH	63.16	29967540
151	Phosphorylation	KEMKLQVYDLPGILA HHHCCEECCHHHHHH	9.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of COX10_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of COX10_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of COX10_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of COX10_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.