GCDH_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: GCDH_HUMAN
• UniProt AC: Q92947
• Protein Name: Glutaryl-CoA dehydrogenase, mitochondrial
• Gene Name: GCDH
• Organism: Homo sapiens (Human).
• Sequence Length: 438
• Subcellular Localization: Mitochondrion matrix.
• Protein Description: Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive..
• Protein Sequence: MALRGVSVRLLSRGPGLHVLRTWVSSAAQTEKGGRTQSQLAKSSRPEFDWQDPLVLEEQLTTDEILIRDTFRTYCQERLMPRILLANRNEVFHREIISEMGELGVLGPTIKGYGCAGVSSVAYGLLARELERVDSGYRSAMSVQSSLVMHPIYAYGSEEQRQKYLPQLAKGELLGCFGLTEPNSGSDPSSMETRAHYNSSNKSYTLNGTKTWITNSPMADLFVVWARCEDGCIRGFLLEKGMRGLSAPRIQGKFSLRASATGMIIMDGVEVPEENVLPGASSLGGPFGCLNNARYGIAWGVLGASEFCLHTARQYALDRMQFGVPLARNQLIQKKLADMLTEITLGLHACLQLGRLKDQDKAAPEMVSLLKRNNCGKALDIARQARDMLGGNGISDEYHVIRHAMNLEAVNTYEGTHDIHALILGRAITGIQAFTASK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
32	Ubiquitination	SSAAQTEKGGRTQSQ HHHHCCCCCCCCHHH	70.79	-
38	Phosphorylation	EKGGRTQSQLAKSSR CCCCCCHHHHHHHCC	26.92	25332170
88	Methylation	PRILLANRNEVFHRE HHHHHHCCCHHHHHH	34.77	-
137	Phosphorylation	LERVDSGYRSAMSVQ HHHHCCCCCCCHHHH	12.83	27196784
142	Phosphorylation	SGYRSAMSVQSSLVM CCCCCCHHHHHHHHH	19.40	24275569
155	Phosphorylation	VMHPIYAYGSEEQRQ HHCCHHHCCCHHHHH	12.29	24275569
157	Phosphorylation	HPIYAYGSEEQRQKY CCHHHCCCHHHHHHH	25.86	24275569
163	Ubiquitination	GSEEQRQKYLPQLAK CCHHHHHHHHHHHHH	51.44	-
202	Ubiquitination	AHYNSSNKSYTLNGT EEECCCCCEEEECCE	46.95	-
240	Acetylation	IRGFLLEKGMRGLSA HHHHHHHCCCCCCCC	58.96	-
240	Ubiquitination	IRGFLLEKGMRGLSA HHHHHHHCCCCCCCC	58.96	-
240	Malonylation	IRGFLLEKGMRGLSA HHHHHHHCCCCCCCC	58.96	26320211
240	2-Hydroxyisobutyrylation	IRGFLLEKGMRGLSA HHHHHHHCCCCCCCC	58.96	-
246	Phosphorylation	EKGMRGLSAPRIQGK HCCCCCCCCCCCCCC	38.77	20068231
255	Phosphorylation	PRIQGKFSLRASATG CCCCCCEEECCCCCE	22.04	25394399
319	Methylation	ARQYALDRMQFGVPL HHHHHHHHHHHCCCH	22.96	-
361	Ubiquitination	GRLKDQDKAAPEMVS CCCCCCCCCHHHHHH	40.59	-
368	Phosphorylation	KAAPEMVSLLKRNNC CCHHHHHHHHHHCCC	27.03	24719451
371	Ubiquitination	PEMVSLLKRNNCGKA HHHHHHHHHCCCHHH	59.37	-
377	Ubiquitination	LKRNNCGKALDIARQ HHHCCCHHHHHHHHH	48.23	-
398	Phosphorylation	GNGISDEYHVIRHAM CCCCCCHHHHHHHCC	13.33	-
429	Phosphorylation	LILGRAITGIQAFTA HHHHHHHHHHHHHHC	27.52	20068231
435	Phosphorylation	ITGIQAFTASK---- HHHHHHHHCCC----	32.79	28857561
437	Phosphorylation	GIQAFTASK------ HHHHHHCCC------	35.52	28857561
438	Acetylation	IQAFTASK------- HHHHHCCC-------	62.99	2380819

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of GCDH_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of GCDH_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of GCDH_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
NOS3_HUMAN	NOS3	physical	21163940
ISCA1_HUMAN	ISCA1	physical	26186194
SYMM_HUMAN	MARS2	physical	26186194
ISCA1_HUMAN	ISCA1	physical	28514442
SYMM_HUMAN	MARS2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 231670: Glutaric aciduria 1 (GA1)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB03147: Flavin adenine dinucleotide