CP24A_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CP24A_HUMAN
• UniProt AC: Q07973
• Protein Name: 1,25-dihydroxyvitamin D(3) 24-hydroxylase, mitochondrial
• Gene Name: CYP24A1
• Organism: Homo sapiens (Human).
• Sequence Length: 514
• Subcellular Localization: Mitochondrion.
• Protein Description: Has a role in maintaining calcium homeostasis. Catalyzes the adrenodoxin-dependent 24-hydroxylation of calcidiol (25-hydroxyvitamin D(3)) and calcitriol (1-alpha,25-dihydroxyvitamin D(3)). The enzyme can perform up to 6 rounds of hydroxylation of calcitriol leading to calcitroic acid. It also shows 23-hydroxylating activity leading to 1-alpha,25-dihydroxyvitamin D(3)-26,23-lactone as end product..
• Protein Sequence: MSSPISKSRSLAAFLQQLRSPRQPPRLVTSTAYTSPQPREVPVCPLTAGGETQNAAALPGPTSWPLLGSLLQILWKGGLKKQHDTLVEYHKKYGKIFRMKLGSFESVHLGSPCLLEALYRTESAYPQRLEIKPWKAYRDYRKEGYGLLILEGEDWQRVRSAFQKKLMKPGEVMKLDNKINEVLADFMGRIDELCDERGHVEDLYSELNKWSFESICLVLYEKRFGLLQKNAGDEAVNFIMAIKTMMSTFGRMMVTPVELHKSLNTKVWQDHTLAWDTIFKSVKACIDNRLEKYSQQPSADFLCDIYHQNRLSKKELYAAVTELQLAAVETTANSLMWILYNLSRNPQVQQKLLKEIQSVLPENQVPRAEDLRNMPYLKACLKESMRLTPSVPFTTRTLDKATVLGEYALPKGTVLMLNTQVLGSSEDNFEDSSQFRPERWLQEKEKINPFAHLPFGVGKRMCIGRRLAELQLHLALCWIVRKYDIQATDNEPVEMLHSGTLVPSRELPIAFCQR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MSSPISKSRS -----CCCCCCHHHH	25.59	24719451
6	Phosphorylation	--MSSPISKSRSLAA --CCCCCCHHHHHHH	28.15	30631047
20	Phosphorylation	AFLQQLRSPRQPPRL HHHHHHCCCCCCCCE	32.78	24719451
35	Phosphorylation	VTSTAYTSPQPREVP EEECCCCCCCCCCCC	14.63	-
125	Phosphorylation	LYRTESAYPQRLEIK HHCCCCCCCCCCCCC	14.80	-
165	Acetylation	VRSAFQKKLMKPGEV HHHHHHHHHCCHHHH	42.93	7975561
220	Phosphorylation	ESICLVLYEKRFGLL HHHHHHHHHHHHCCC	16.36	22817900
258	Ubiquitination	RMMVTPVELHKSLNT CCCCCHHHHHHHCCC	46.49	21906983
384	Phosphorylation	LKACLKESMRLTPSV HHHHHHHHHCCCCCC	13.96	29083192
388	Phosphorylation	LKESMRLTPSVPFTT HHHHHCCCCCCCCCC	11.80	29083192
390	Phosphorylation	ESMRLTPSVPFTTRT HHHCCCCCCCCCCCC	36.87	29083192
394	Phosphorylation	LTPSVPFTTRTLDKA CCCCCCCCCCCCCCE	14.86	29083192
395	Phosphorylation	TPSVPFTTRTLDKAT CCCCCCCCCCCCCEE	23.26	29083192
400	Ubiquitination	FTTRTLDKATVLGEY CCCCCCCCEEEEEEE	49.41	22817900
407	Phosphorylation	KATVLGEYALPKGTV CEEEEEEEECCCCEE	16.19	-
444	2-Hydroxyisobutyrylation	PERWLQEKEKINPFA HHHHHHHHHCCCCCC	51.88	-
483	Phosphorylation	LCWIVRKYDIQATDN HHHHHHHCCCCCCCC	14.02	29759185
488	Phosphorylation	RKYDIQATDNEPVEM HHCCCCCCCCCCEEE	24.00	29759185
498	Phosphorylation	EPVEMLHSGTLVPSR CCEEEECCCEECCCC	29.52	29759185
500	Phosphorylation	VEMLHSGTLVPSREL EEEECCCEECCCCCC	27.83	29759185
504	Phosphorylation	HSGTLVPSRELPIAF CCCEECCCCCCCCEE	30.79	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CP24A_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CP24A_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CP24A_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CP24A_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 143880: Hypercalcemia infantile (HCAI)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00146: Calcidiol
• DB02300: Calcipotriol
• DB00136: Calcitriol
• DB01285: Corticotropin
• DB00153: Ergocalciferol
• DB00910: Paricalcitol