MRP7_HUMAN - dbPTM
MRP7_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID MRP7_HUMAN
UniProt AC Q5T3U5
Protein Name Multidrug resistance-associated protein 7
Gene Name ABCC10
Organism Homo sapiens (Human).
Sequence Length 1492
Subcellular Localization Cell membrane
Multi-pass membrane protein .
Protein Description ATP-dependent transporter probably involved in cellular detoxification through lipophilic anion extrusion..
Protein Sequence MERLLAQLCGSSAAWPLPLWEGDTTGHCFTQLVLSALPHALLAVLSACYLGTPRSPDYILPCSPGWRLRLAASFLLSVFPLLDLLPVALPPGAGPGPIGLEVLAGCVAAVAWISHSLALWVLAHSPHGHSRGPLALALVALLPAPALVLTVLWHCQRGTLLPPLLPGPMARLCLLILQLAALLAYALGWAAPGGPREPWAQEPLLPEDQEPEVAEDGESWLSRFSYAWLAPLLARGACGELRQPQDICRLPHRLQPTYLARVFQAHWQEGARLWRALYGAFGRCYLALGLLKLVGTMLGFSGPLLLSLLVGFLEEGQEPLSHGLLYALGLAGGAVLGAVLQNQYGYEVYKVTLQARGAVLNILYCKALQLGPSRPPTGEALNLLGTDSERLLNFAGSFHEAWGLPLQLAITLYLLYQQVGVAFVGGLILALLLVPVNKVIATRIMASNQEMLQHKDARVKLVTELLSGIRVIKFCGWEQALGARVEACRARELGRLRVIKYLDAACVYLWAALPVVISIVIFITYVLMGHQLTATKVFTALALVRMLILPLNNFPWVINGLLEAKVSLDRIQLFLDLPNHNPQAYYSPDPPAEPSTVLELHGALFSWDPVGTSLETFISHLEVKKGMLVGIVGKVGCGKSSLLAAIAGELHRLRGHVAVRGLSKGFGLATQEPWIQFATIRDNILFGKTFDAQLYKEVLEACALNDDLSILPAGDQTEVGEKGVTLSGGQRARIALARAVYQEKELYLLDDPLAAVDADVANHLLHRCILGMLSYTTRLLCTHRTEYLERADAVLLMEAGRLIRAGPPSEILPLVQAVPKAWAENGQESDSATAQSVQNPEKTKEGLEEEQSTSGRLLQEESKKEGAVALHVYQAYWKAVGQGLALAILFSLLLMQATRNAADWWLSHWISQLKAENSSQEAQPSTSPASMGLFSPQLLLFSPGNLYIPVFPLPKAAPNGSSDIRFYLTVYATIAGVNSLCTLLRAVLFAAGTLQAAATLHRRLLHRVLMAPVTFFNATPTGRILNRFSSDVACADDSLPFILNILLANAAGLLGLLAVLGSGLPWLLLLLPPLSIMYYHVQRHYRASSRELRRLGSLTLSPLYSHLADTLAGLSVLRATGATYRFEEENLRLLELNQRCQFATSATMQWLDIRLQLMGAAVVSAIAGIALVQHQQGLANPGLVGLSLSYALSLTGLLSGLVSSFTQTEAMLVSVERLEEYTCDLPQEPQGQPLQLGTGWLTQGGVEFQDVVLAYRPGLPNALDGVTFCVQPGEKLGIVGRTGSGKSSLLLVLFRLLEPSSGRVLLDGVDTSQLELAQLRSQLAIIPQEPFLFSGTVRENLDPQGLHKDRALWQALKQCHLSEVITSMGGLDGELGEGGRSLSLGQRQLLCLARALLTDAKILCIDEATASVDQKTDQLLQQTICKRFANKTVLTIAHRLNTILNSDRVLVLQAGRVVELDSPATLRNQPHSLFQQLLQSSQQGVPASLGGP
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
412 (in isoform 2)Ubiquitination-2.0121890473
417 (in isoform 2)Ubiquitination-31.3021890473
447PhosphorylationIATRIMASNQEMLQH
HHHHHHHCCHHHHCC		22.9730619164
455UbiquitinationNQEMLQHKDARVKLV
CHHHHCCCCHHHHHH		39.8721906983
455 (in isoform 1)Ubiquitination-39.8721890473
460 (in isoform 1)Ubiquitination-31.5221890473
460UbiquitinationQHKDARVKLVTELLS
CCCCHHHHHHHHHHH		31.5221890473
463PhosphorylationDARVKLVTELLSGIR
CHHHHHHHHHHHCCE		31.2118220336
467PhosphorylationKLVTELLSGIRVIKF
HHHHHHHHCCEEEHH		44.8112566991
473UbiquitinationLSGIRVIKFCGWEQA
HHCCEEEHHCCHHHH		31.57-
501PhosphorylationGRLRVIKYLDAACVY
CCHHHHHHHHHHHHH		9.9324043423
508PhosphorylationYLDAACVYLWAALPV
HHHHHHHHHHHHHHH		9.0824043423
518PhosphorylationAALPVVISIVIFITY
HHHHHHHHHHHHHHH		10.1324043423
524PhosphorylationISIVIFITYVLMGHQ
HHHHHHHHHHHHCCC		9.2324043423
525PhosphorylationSIVIFITYVLMGHQL
HHHHHHHHHHHCCCC		6.1824043423
533PhosphorylationVLMGHQLTATKVFTA
HHHCCCCHHHHHHHH		26.2224043423
535PhosphorylationMGHQLTATKVFTALA
HCCCCHHHHHHHHHH		23.6224043423
636 (in isoform 2)Ubiquitination-20.2521890473
660 (in isoform 2)Ubiquitination-30.5121890473
663PhosphorylationHVAVRGLSKGFGLAT
CHHHHCCCCCCCCCC		33.2950558591
664 (in isoform 1)Ubiquitination-64.4021890473
664UbiquitinationVAVRGLSKGFGLATQ
HHHHCCCCCCCCCCC		64.4021890473
670PhosphorylationSKGFGLATQEPWIQF
CCCCCCCCCCCCEEE		38.2150558597
679PhosphorylationEPWIQFATIRDNILF
CCCEEEEEHHHCEEC		20.1750558603
688 (in isoform 1)Ubiquitination-38.3921890473
688UbiquitinationRDNILFGKTFDAQLY
HHCEECCCCCCHHHH		38.3921890473
717PhosphorylationILPAGDQTEVGEKGV
EECCCCCCCCCCCCE		37.0627542207
727PhosphorylationGEKGVTLSGGQRARI
CCCCEECCHHHHHHH		31.3524719451
774PhosphorylationRCILGMLSYTTRLLC
HHHHHHHHHHHHHHH		16.1328509920
775PhosphorylationCILGMLSYTTRLLCT
HHHHHHHHHHHHHHH		14.2528509920
776PhosphorylationILGMLSYTTRLLCTH
HHHHHHHHHHHHHHC		11.3228509920
785PhosphorylationRLLCTHRTEYLERAD
HHHHHCCHHHHHHCC		22.7524043423
787PhosphorylationLCTHRTEYLERADAV
HHHCCHHHHHHCCHH		17.1624043423
814 (in isoform 2)Ubiquitination-3.9021890473
816 (in isoform 2)Ubiquitination-44.3021890473
842UbiquitinationQSVQNPEKTKEGLEE
HHHCCHHHHHHHHHH		67.1821906983
842 (in isoform 1)Ubiquitination-67.1821890473
844UbiquitinationVQNPEKTKEGLEEEQ
HCCHHHHHHHHHHHH		61.932190698
844 (in isoform 1)Ubiquitination-61.9321890473
852PhosphorylationEGLEEEQSTSGRLLQ
HHHHHHHHHHHCCCC		28.0227135362
854PhosphorylationLEEEQSTSGRLLQEE
HHHHHHHHHCCCCHH		27.4527135362
873PhosphorylationGAVALHVYQAYWKAV
CCCHHHHHHHHHHHH		4.087116635
911PhosphorylationWWLSHWISQLKAENS
HHHHHHHHHHHHHCC		25.0324719451
1115PhosphorylationADTLAGLSVLRATGA
HHHHHHHHHHHHCCC		20.4224719451
1282PhosphorylationKLGIVGRTGSGKSSL
EEEEEECCCCCHHHH		29.7524719451
1288PhosphorylationRTGSGKSSLLLVLFR
CCCCCHHHHHHHHHH		26.9024719451
1301PhosphorylationFRLLEPSSGRVLLDG
HHHHCCCCCCEEECC		41.1424719451
1415UbiquitinationATASVDQKTDQLLQQ
CCCCCCHHHHHHHHH		49.99-
1442PhosphorylationTIAHRLNTILNSDRV
HHHHHHHHHHCCCCE		31.2830987973
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of MRP7_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of MRP7_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of MRP7_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of MRP7_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
DB00091Cyclosporine
DB00987Cytarabine
DB00694Daunorubicin
DB01248Docetaxel
DB00997Doxorubicin
DB00783Estradiol
DB00773Etoposide
DB00441Gemcitabine
DB00563Methotrexate
DB01229Paclitaxel
DB00203Sildenafil
DB00300Tenofovir
DB00661Verapamil
DB00541Vincristine
Regulatory Network of MRP7_HUMAN

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Related Literatures of Post-Translational Modification
Phosphorylation
ReferencePubMed
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis.";
Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III;
J. Proteome Res. 7:1346-1351(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-463 AND SER-467, ANDMASS SPECTROMETRY.

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