CBR3_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CBR3_HUMAN
• UniProt AC: O75828
• Protein Name: Carbonyl reductase [NADPH] 3
• Gene Name: CBR3
• Organism: Homo sapiens (Human).
• Sequence Length: 277
• Subcellular Localization: Cytoplasm .
• Protein Description: Has low NADPH-dependent oxidoreductase activity towards 4-benzoylpyridine and menadione (in vitro)..
• Protein Sequence: MSSCSRVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAEGLSPRFHQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAVAFKSDDPMPFDIKAEMTLKTNFFATRNMCNELLPIMKPHGRVVNISSLQCLRAFENCSEDLQERFHSETLTEGDLVDLMKKFVEDTKNEVHEREGWPNSPYGVSKLGVTVLSRILARRLDEKRKADRILVNACCPGPVKTDMDGKDSIRTVEEGAETPVYLALLPPDATEPQGQLVHDKVVQNW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Phosphorylation	------MSSCSRVAL ------CCCCCCEEE	39.80	-
2	Acetylation	------MSSCSRVAL ------CCCCCCEEE	39.80	-
11	Phosphorylation	CSRVALVTGANRGIG CCCEEECCCCCCCHH	31.28	-
30	Phosphorylation	RELCRQFSGDVVLTA HHHHHHCCCCEEEEH	26.24	27251275
36	Phosphorylation	FSGDVVLTARDVARG CCCCEEEEHHHHHHH	14.19	24719451
56	Phosphorylation	QLQAEGLSPRFHQLD HHHHCCCCCCCCCCC	25.53	20873877
69	Phosphorylation	LDIDDLQSIRALRDF CCHHHHHHHHHHHHH	22.72	24076635
81	Phosphorylation	RDFLRKEYGGLNVLV HHHHHHHHCCEEEEE	21.38	-
97	Phosphorylation	NAAVAFKSDDPMPFD CEEEEECCCCCCCCC	40.57	28348404
112	Ubiquitination	IKAEMTLKTNFFATR EEEEEEECCCCEEHH	32.05	21890473
160	Phosphorylation	DLQERFHSETLTEGD HHHHHHHHCCCCCCC	29.57	25850435
162	Phosphorylation	QERFHSETLTEGDLV HHHHHHCCCCCCCHH	41.83	25850435
164	Phosphorylation	RFHSETLTEGDLVDL HHHHCCCCCCCHHHH	45.39	25850435
173	Acetylation	GDLVDLMKKFVEDTK CCHHHHHHHHHHHHH	50.81	30587473
192	Phosphorylation	EREGWPNSPYGVSKL HHCCCCCCCCCHHHH	18.54	28655764
194	Phosphorylation	EGWPNSPYGVSKLGV CCCCCCCCCHHHHHH	29.94	25850435
198	Ubiquitination	NSPYGVSKLGVTVLS CCCCCHHHHHHHHHH	47.02	-
205	Phosphorylation	KLGVTVLSRILARRL HHHHHHHHHHHHHHC	16.97	24076635
226	S-nitrosocysteine	DRILVNACCPGPVKT CEEEEECCCCCCEEC	2.13	-
226	S-nitrosylation	DRILVNACCPGPVKT CEEEEECCCCCCEEC	2.13	19483679
227	S-nitrosocysteine	RILVNACCPGPVKTD EEEEECCCCCCEECC	3.97	-
227	S-nitrosylation	RILVNACCPGPVKTD EEEEECCCCCCEECC	3.97	19483679
240	Phosphorylation	TDMDGKDSIRTVEEG CCCCCCCCEEEHHHC	19.91	27251275
250	Phosphorylation	TVEEGAETPVYLALL EHHHCCCCCEEEEEC	19.95	27642862
253	Phosphorylation	EGAETPVYLALLPPD HCCCCCEEEEECCCC	6.35	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CBR3_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CBR3_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CBR3_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SDCB1_HUMAN	SDCBP	physical	25416956
BTBD9_HUMAN	BTBD9	physical	26186194
MSS4_HUMAN	RABIF	physical	26344197
CBR1_HUMAN	CBR1	physical	26496610
LDLR_HUMAN	LDLR	physical	26496610
KI67_HUMAN	MKI67	physical	26496610
RS10_HUMAN	RPS10	physical	26496610
CCNL2_HUMAN	CCNL2	physical	26496610
CBR1_HUMAN	CBR1	physical	28514442
BTBD9_HUMAN	BTBD9	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00997: Doxorubicin