TM248_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM248_HUMAN
• UniProt AC: Q9NWD8
• Protein Name: Transmembrane protein 248
• Gene Name: TMEM248
• Organism: Homo sapiens (Human).
• Sequence Length: 314
• Subcellular Localization: Membrane ; Multi-pass membrane protein .
• Protein Sequence: MFSINPLENLKVYISSRPPLVVFMISVSAMAIAFLTLGYFFKIKEIKSPEMAEDWNTFLLRFNDLDLCVSENETLKHLTNDTTTPESTMTSGQARASTQSPQALEDSGPVNISVSITLTLDPLKPFGGYSRNVTHLYSTILGHQIGLSGREAHEEINITFTLPTAWSSDDCALHGHCEQVVFTACMTLTASPGVFPVTVQPPHCVPDTYSNATLWYKIFTTARDANTKYAQDYNPFWCYKGAIGKVYHALNPKLTVIVPDDDRSLINLHLMHTSYFLFVMVITMFCYAVIKGRPSKLRQSNPEFCPEKVALAEA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MFSINPLENL -----CCCCCCHHCC	21.84	30631047
15	Phosphorylation	ENLKVYISSRPPLVV HCCEEEECCCCCEEE	11.56	30631047
48	Phosphorylation	FKIKEIKSPEMAEDW EEEEECCCHHHHCCC	31.58	-
76	Ubiquitination	VSENETLKHLTNDTT ECCCCCHHHHCCCCC	43.94	-
82	Phosphorylation	LKHLTNDTTTPESTM HHHHCCCCCCCCHHC	34.34	22210691
83	Phosphorylation	KHLTNDTTTPESTMT HHHCCCCCCCCHHCC	43.12	22210691
88	O-linked_Glycosylation	DTTTPESTMTSGQAR CCCCCCHHCCCCCCC	23.86	OGP
91	Phosphorylation	TPESTMTSGQARAST CCCHHCCCCCCCCCC	20.34	22210691
228	Ubiquitination	TARDANTKYAQDYNP CHHHCCCCCCCCCCC	38.09	-
240	Ubiquitination	YNPFWCYKGAIGKVY CCCCEEEEHHHHHHH	38.44	-
245	Ubiquitination	CYKGAIGKVYHALNP EEEHHHHHHHHHHCC	33.24	-
300	Phosphorylation	RPSKLRQSNPEFCPE CHHHHHHCCCCCCHH	48.17	25849741
308	Ubiquitination	NPEFCPEKVALAEA- CCCCCHHHHHHHCC-	20.25	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM248_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM248_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM248_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
SYNE4_HUMAN	SYNE4	physical	25416956
ABCA2_HUMAN	ABCA2	physical	26496610
AUP1_HUMAN	AUP1	physical	26496610
PKD2_HUMAN	PKD2	physical	26496610
PZP_HUMAN	PZP	physical	26496610
ROBO2_HUMAN	ROBO2	physical	26496610
RIR2_HUMAN	RRM2	physical	26496610
TAF1_HUMAN	TAF1	physical	26496610
BCL7B_HUMAN	BCL7B	physical	26496610
CE162_HUMAN	CEP162	physical	26496610
KI21B_HUMAN	KIF21B	physical	26496610
QCR8_HUMAN	UQCRQ	physical	26496610
VPS4A_HUMAN	VPS4A	physical	26496610
ASTE1_HUMAN	ASTE1	physical	26496610
SSH3_HUMAN	SSH3	physical	26496610
UBFD1_HUMAN	UBFD1	physical	26496610

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.