CASC1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CASC1_HUMAN
• UniProt AC: Q6TDU7
• Protein Name: Protein CASC1
• Gene Name: CASC1
• Organism: Homo sapiens (Human).
• Sequence Length: 716
• Protein Sequence: MSGSKKKKVTKAERLKLLQEEEERRLKEEEEARLKYEKEEMERLEIQRIEKEKWHRLEAKDLERRNEELEELYLLERCFPEAEKLKQETKLLSQWKHYIQCDGSPDPSVAQEMNTFISLWKEKTNETFEEVIEKSKVVLNLIEKLKFILLETPPCDLQDKNIIQYQESILQLQELLHLKFGVATEILLKQASTLADLDSGNMEKVIKDENVTLYVWANLKKNPRHRSVRFSETQIGFEIPRILATSDIAVRLLHTHYDHVSALHPVSTPSKEYTSAVTELVKDDVKNVEKAISKEVEEESKQQERGSHLIQEEEIKVEEEQGDIEVKMSSAEEESEAIKCEREMKVLSETVSAAQLLLVENSSEKPDFFEDNVVDLCQFTTLGGVYHLDILELPPQCKPVKGWMIVEILKEGLQKYTYPPETTEEFETENAFPPIEVTLEVHENVIFFEDPVVVRWDAEGKHWRTDGISNVSYKPKERLVTFSLDTFGPVTLIQDAHINMPYQSWELRPLDVNKVLLTVTTVFTEIQIQIKENLCMLSSIKLKDKKHISILEGTWMTPIPFIIALKEAGLNIFPTRHSHFYVIINNKVPLVEVKAYRQMALLSSAFAFGWSKWNLLCNSTKVVFKVREHLTEACTENPNWALLMFSGDRAQRLKIKEESEAFSEALKEETEFHSTLYHMVKDFASEEAMEKVRSSNCQFVNSVCHMLLSTRLLSYS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
93	Phosphorylation	KQETKLLSQWKHYIQ HHHHHHHHHCCHHHC	44.42	25159151
192	Phosphorylation	EILLKQASTLADLDS HHHHHHHHHHHCCCC	22.81	-
193	Phosphorylation	ILLKQASTLADLDSG HHHHHHHHHHCCCCC	29.05	-
199	Phosphorylation	STLADLDSGNMEKVI HHHHCCCCCCHHEEE	39.09	-
246	Phosphorylation	IPRILATSDIAVRLL CCHHHCCCHHHHHHH	22.78	-
348	Phosphorylation	EREMKVLSETVSAAQ HHHHHHHHHHCCHHH	33.92	29978859
350	Phosphorylation	EMKVLSETVSAAQLL HHHHHHHHCCHHHHH	19.18	29978859
352	Phosphorylation	KVLSETVSAAQLLLV HHHHHHCCHHHHHHH	25.88	29978859
362	Phosphorylation	QLLLVENSSEKPDFF HHHHHCCCCCCCCCC	26.77	29978859
363	Phosphorylation	LLLVENSSEKPDFFE HHHHCCCCCCCCCCC	62.31	29978859
472	Phosphorylation	TDGISNVSYKPKERL CCCCCCCCCCCHHHE	31.52	-
504	Phosphorylation	HINMPYQSWELRPLD EECCCCCCCCCCCCC	19.37	24719451
538	Phosphorylation	KENLCMLSSIKLKDK HHCCHHHCCCCCCCC	11.79	24719451
670	Phosphorylation	SEALKEETEFHSTLY HHHHHHHHHHHHHHH	45.07	-
674	Phosphorylation	KEETEFHSTLYHMVK HHHHHHHHHHHHHHH	25.98	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CASC1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CASC1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CASC1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RUND1_HUMAN	RUNDC1	physical	28514442
LRIF1_HUMAN	LRIF1	physical	28514442
MYO9A_HUMAN	MYO9A	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.