TPPC8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TPPC8_HUMAN
• UniProt AC: Q9Y2L5
• Protein Name: Trafficking protein particle complex subunit 8
• Gene Name: TRAPPC8
• Organism: Homo sapiens (Human).
• Sequence Length: 1435
• Subcellular Localization: Golgi apparatus, cis-Golgi network.
• Protein Description: May be involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage..
• Protein Sequence: MAQCVQSVQELIPDSFVPCVAALCSDEAERLTRLNHLSFAELLKPFSRLTSEVHMRDPNNQLHVIKNLKIAVSNIVTQPPQPGAIRKLLNDVVSGSQPAEGLVANVITAGDYDLNISATTPWFESYRETFLQSMPALDHEFLNHYLACMLVASSSEAEPVEQFSKLSQEQHRIQHNSDYSYPKWFIPNTLKYYVLLHDVSAGDEQRAESIYEEMKQKYGTQGCYLLKINSRTSNRASDEQIPDPWSQYLQKNSIQNQESYEDGPCTITSNKNSDNNLLSLDGLDNEVKDGLPNNFRAHPLQLEQSSDPSNSIDGPDHLRSASSLHETKKGNTGIIHGACLTLTDHDRIRQFIQEFTFRGLLPHIEKTIRQLNDQLISRKGLSRSLFSATKKWFSGSKVPEKSINDLKNTSGLLYPPEAPELQIRKMADLCFLVQHYDLAYSCYHTAKKDFLNDQAMLYAAGALEMAAVSAFLQPGAPRPYPAHYMDTAIQTYRDICKNMVLAERCVLLSAELLKSQSKYSEAAALLIRLTSEDSDLRSALLLEQAAHCFINMKSPMVRKYAFHMILAGHRFSKAGQKKHALRCYCQAMQVYKGKGWSLAEDHINFTIGRQSYTLRQLDNAVSAFRHILINESKQSAAQQGAFLREYLYVYKNVSQLSPDGPLPQLPLPYINSSATRVFFGHDRRPADGEKQAATHVSLDQEYDSESSQQWRELEEQVVSVVNKGVIPSNFHPTQYCLNSYSDNSRFPLAVVEEPITVEVAFRNPLKVLLLLTDLSLLWKFHPKDFSGKDNEEVKQLVTSEPEMIGAEVISEFLINGEESKVARLKLFPHHIGELHILGVVYNLGTIQGSMTVDGIGALPGCHTGKYSLSMSVRGKQDLEIQGPRLNNTKEEKTSVKYGPDRRLDPIITEEMPLLEVFFIHFPTGLLCGEIRKAYVEFVNVSKCPLTGLKVVSKRPEFFTFGGNTAVLTPLSPSASENCSAYKTVVTDATSVCTALISSASSVDFGIGTGSQPEVIPVPLPDTVLLPGASVQLPMWLRGPDEEGVHEINFLFYYESVKKQPKIRHRILRHTAIICTSRSLNVRATVCRSNSLENEEGRGGNMLVFVDVENTNTSEAGVKEFHIVQVSSSSKHWKLQKSVNLSENKDTKLASREKGKFCFKAIRCEKEEAATQSSEKYTFADIIFGNEQIISSASPCADFFYRSLSSELKKPQAHLPVHTEKQSTEDAVRLIQKCSEVDLNIVILWKAYVVEDSKQLILEGQHHVILRTIGKEAFSYPQKQEPPEMELLKFFRPENITVSSRPSVEQLSSLIKTSLHYPESFNHPFHQKSLCLVPVTLLLSNCSKADVDVIVDLRHKTTSPEALEIHGSFTWLGQTQYKLQLKSQEIHSLQLKACFVHTGVYNLGTPRVFAKLSDQVTVFETSQQNSMPALIIISNV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MAQCVQSVQELIPD -CHHHHHHHHHHCCC	12.84	-
38	Phosphorylation	LTRLNHLSFAELLKP HHHHHCCCHHHHHHH	18.17	-
44	Ubiquitination	LSFAELLKPFSRLTS CCHHHHHHHHHHHCC	57.55	-
66	Ubiquitination	NNQLHVIKNLKIAVS CCCEEEEEECEEEEE	55.96	29967540
69	Ubiquitination	LHVIKNLKIAVSNIV EEEEEECEEEEEHHC	37.70	29967540
133	Ubiquitination	YRETFLQSMPALDHE HHHHHHHHCCCCCHH	28.96	22817900
179	Phosphorylation	RIQHNSDYSYPKWFI HHHCCCCCCCCCCCC	15.21	22817900
180	Phosphorylation	IQHNSDYSYPKWFIP HHCCCCCCCCCCCCC	39.69	24719451
181	Phosphorylation	QHNSDYSYPKWFIPN HCCCCCCCCCCCCCC	11.55	25884760
183	Ubiquitination	NSDYSYPKWFIPNTL CCCCCCCCCCCCCHH	46.64	29967540
192	Phosphorylation	FIPNTLKYYVLLHDV CCCCHHEEEEEEEEC	11.26	18083107
193	Phosphorylation	IPNTLKYYVLLHDVS CCCHHEEEEEEEECC	5.30	18083107
215	Ubiquitination	ESIYEEMKQKYGTQG HHHHHHHHHHHCCCC	47.09	29967540
217	Ubiquitination	IYEEMKQKYGTQGCY HHHHHHHHHCCCCEE	39.88	29967540
227	Ubiquitination	TQGCYLLKINSRTSN CCCEEEEEECCCCCC	36.93	32015554
232	Phosphorylation	LLKINSRTSNRASDE EEEECCCCCCCCCCC	30.12	23186163
233	Phosphorylation	LKINSRTSNRASDEQ EEECCCCCCCCCCCC	24.17	23186163
237	Phosphorylation	SRTSNRASDEQIPDP CCCCCCCCCCCCCCH	38.14	23186163
240	Ubiquitination	SNRASDEQIPDPWSQ CCCCCCCCCCCHHHH	58.46	22817900
244	Ubiquitination	SDEQIPDPWSQYLQK CCCCCCCHHHHHHHH	27.54	22817900
251	Ubiquitination	PWSQYLQKNSIQNQE HHHHHHHHHCCCCCC	50.49	29967540
253	Phosphorylation	SQYLQKNSIQNQESY HHHHHHHCCCCCCCC	32.36	27251275
259	Phosphorylation	NSIQNQESYEDGPCT HCCCCCCCCCCCCCE	24.86	21815630
260	Phosphorylation	SIQNQESYEDGPCTI CCCCCCCCCCCCCEE	19.79	29978859
266	Phosphorylation	SYEDGPCTITSNKNS CCCCCCCEEECCCCC	30.35	29978859
268	Phosphorylation	EDGPCTITSNKNSDN CCCCCEEECCCCCCC	14.22	26074081
269	Phosphorylation	DGPCTITSNKNSDNN CCCCEEECCCCCCCC	41.79	26657352
271	Ubiquitination	PCTITSNKNSDNNLL CCEEECCCCCCCCEE	58.56	29967540
273	Phosphorylation	TITSNKNSDNNLLSL EEECCCCCCCCEECC	43.24	25159151
279	Phosphorylation	NSDNNLLSLDGLDNE CCCCCEECCCCCCHH	27.81	28348404
288	Ubiquitination	DGLDNEVKDGLPNNF CCCCHHHCCCCCCCC	39.64	29967540
299	Ubiquitination	PNNFRAHPLQLEQSS CCCCCCCCCCHHHCC	22.33	27667366
305	Phosphorylation	HPLQLEQSSDPSNSI CCCCHHHCCCCCCCC	27.60	23403867
306	Phosphorylation	PLQLEQSSDPSNSID CCCHHHCCCCCCCCC	53.92	23403867
309	Phosphorylation	LEQSSDPSNSIDGPD HHHCCCCCCCCCCHH	48.47	23403867
311	Phosphorylation	QSSDPSNSIDGPDHL HCCCCCCCCCCHHHH	26.79	23401153
322	Phosphorylation	PDHLRSASSLHETKK HHHHHHHHHCCCCCC	34.38	24275569
356	Phosphorylation	RQFIQEFTFRGLLPH HHHHHHHHHHCHHHH	16.21	22210691
382	Ubiquitination	LISRKGLSRSLFSAT HHHCCCCCHHHHHHH	28.61	22817900
387	Phosphorylation	GLSRSLFSATKKWFS CCCHHHHHHHHHHHC	40.08	29396449
389	Phosphorylation	SRSLFSATKKWFSGS CHHHHHHHHHHHCCC	31.77	23186163
390	Ubiquitination	RSLFSATKKWFSGSK HHHHHHHHHHHCCCC	47.96	-
391	Ubiquitination	SLFSATKKWFSGSKV HHHHHHHHHHCCCCC	49.47	-
397	Ubiquitination	KKWFSGSKVPEKSIN HHHHCCCCCCHHHHH	66.39	29967540
401	Acetylation	SGSKVPEKSINDLKN CCCCCCHHHHHHHCC	51.03	25953088
401	Ubiquitination	SGSKVPEKSINDLKN CCCCCCHHHHHHHCC	51.03	29967540
407	Ubiquitination	EKSINDLKNTSGLLY HHHHHHHCCCCCCCC	62.13	21906983
407 (in isoform 1)	Ubiquitination	-	62.13	21890473
407 (in isoform 2)	Ubiquitination	-	62.13	21890473
408	Ubiquitination	KSINDLKNTSGLLYP HHHHHHCCCCCCCCC	46.93	22817900
410	Phosphorylation	INDLKNTSGLLYPPE HHHHCCCCCCCCCCC	36.52	28555341
489	Ubiquitination	AHYMDTAIQTYRDIC CHHHHHHHHHHHHHH	3.23	22817900
493	Ubiquitination	DTAIQTYRDICKNMV HHHHHHHHHHHHHHH	30.15	22817900
514	Ubiquitination	LLSAELLKSQSKYSE HHHHHHHHCCCCHHH	60.10	22817900
514 (in isoform 1)	Ubiquitination	-	60.10	21890473
514 (in isoform 2)	Ubiquitination	-	60.10	21890473
515	Ubiquitination	LSAELLKSQSKYSEA HHHHHHHCCCCHHHH	39.39	22817900
518	Ubiquitination	ELLKSQSKYSEAAAL HHHHCCCCHHHHHHH	45.20	22817900
519	Ubiquitination	LLKSQSKYSEAAALL HHHCCCCHHHHHHHH	19.59	22817900
548	Ubiquitination	LLEQAAHCFINMKSP HHHHHHHHHHHCCCH	2.92	27667366
560	Phosphorylation	KSPMVRKYAFHMILA CCHHHHHHHHHHHHH	12.16	-
573	Acetylation	LAGHRFSKAGQKKHA HHCCCCCHHCCHHHH	54.55	19819251
573	Ubiquitination	LAGHRFSKAGQKKHA HHCCCCCHHCCHHHH	54.55	27667366
574	Ubiquitination	AGHRFSKAGQKKHAL HCCCCCHHCCHHHHH	25.17	27667366
577	Acetylation	RFSKAGQKKHALRCY CCCHHCCHHHHHHHH	45.68	19819261
578	Acetylation	FSKAGQKKHALRCYC CCHHCCHHHHHHHHH	26.65	19819271
584	Phosphorylation	KKHALRCYCQAMQVY HHHHHHHHHHHHHHH	4.91	22817900
594	Ubiquitination	AMQVYKGKGWSLAED HHHHHCCCCCCCCCC	53.72	-
613	Phosphorylation	TIGRQSYTLRQLDNA EECCCCEEHHHHHHH	22.25	24719451
615	Ubiquitination	GRQSYTLRQLDNAVS CCCCEEHHHHHHHHH	27.50	24816145
657	Phosphorylation	YKNVSQLSPDGPLPQ EECHHHCCCCCCCCC	17.20	24076635
690	Ubiquitination	RRPADGEKQAATHVS CCCCCCCCCCCCCCC	51.25	29967540
723	Ubiquitination	QVVSVVNKGVIPSNF HHHHHHHCCCCCCCC	42.83	29967540
783	Ubiquitination	LLWKFHPKDFSGKDN HHHHCCCCCCCCCCH	63.94	29967540
786	Phosphorylation	KFHPKDFSGKDNEEV HCCCCCCCCCCHHHH	55.88	26074081
798	Phosphorylation	EEVKQLVTSEPEMIG HHHHHHHHCCHHHHC	35.64	26074081
799	Phosphorylation	EVKQLVTSEPEMIGA HHHHHHHCCHHHHCH	43.61	26074081
810	Phosphorylation	MIGAEVISEFLINGE HHCHHHHHHHHCCCC	27.72	26074081
841	Phosphorylation	LHILGVVYNLGTIQG HEEEEEEEECCCCCC	11.41	19835603
851	Phosphorylation	GTIQGSMTVDGIGAL CCCCCCEEECCCCCC	19.69	19835603
864	Ubiquitination	ALPGCHTGKYSLSMS CCCCCCCCCEEEEEE	11.84	24816145
866	Phosphorylation	PGCHTGKYSLSMSVR CCCCCCCEEEEEEEC	19.05	27642862
875	Ubiquitination	LSMSVRGKQDLEIQG EEEEECCCCCEEEEC	30.03	29967540
889	Ubiquitination	GPRLNNTKEEKTSVK CCCCCCCCCCHHCCC	67.03	24816145
890	Ubiquitination	PRLNNTKEEKTSVKY CCCCCCCCCHHCCCC	63.79	24816145
942	Ubiquitination	VEFVNVSKCPLTGLK EEEEECCCCCCCCCE	35.27	29967540
964	Phosphorylation	FFTFGGNTAVLTPLS CEEECCCEEEECCCC	22.78	-
968	Phosphorylation	GGNTAVLTPLSPSAS CCCEEEECCCCCCCC	18.65	28464451
971	Phosphorylation	TAVLTPLSPSASENC EEEECCCCCCCCCCC	20.29	25159151
973	Phosphorylation	VLTPLSPSASENCSA EECCCCCCCCCCCCC	40.84	28450419
975	Phosphorylation	TPLSPSASENCSAYK CCCCCCCCCCCCCCC	33.41	28450419
979	Phosphorylation	PSASENCSAYKTVVT CCCCCCCCCCCEEEC	46.33	28450419
981	Phosphorylation	ASENCSAYKTVVTDA CCCCCCCCCEEECCH	7.30	28450419
1014	Ubiquitination	GTGSQPEVIPVPLPD CCCCCCCEECCCCCC	8.35	21890473
1057	Acetylation	LFYYESVKKQPKIRH EEEHHHHCCCHHHHH	55.78	25953088
1088	Phosphorylation	VRATVCRSNSLENEE CEEEEEECCCCCCCC	26.16	23927012
1090	Phosphorylation	ATVCRSNSLENEEGR EEEEECCCCCCCCCC	38.00	21815630
1136	Ubiquitination	SKHWKLQKSVNLSEN CCCEEECCCEECCCC	67.80	29967540
1147	Acetylation	LSENKDTKLASREKG CCCCCCCCCHHHHHC	52.79	19824437
1155	Acetylation	LASREKGKFCFKAIR CHHHHHCCEEEEEEE	50.45	19824447
1165	Ubiquitination	FKAIRCEKEEAATQS EEEEECCHHHHCCCC	65.56	33845483
1209	Ubiquitination	SLSSELKKPQAHLPV HHCHHHCCCCCCCCC	55.79	29967540
1212 (in isoform 2)	Ubiquitination	-	18.08	21890473
1220	Ubiquitination	HLPVHTEKQSTEDAV CCCCCCCCCCHHHHH	51.18	29967540
1263	Ubiquitination	ILEGQHHVILRTIGK HHHCCCEEEEEECCH	4.07	21890473
1278	Ubiquitination	EAFSYPQKQEPPEME HHHCCCCCCCCCCCH	52.72	29967540
1288	Ubiquitination	PPEMELLKFFRPENI CCCCHHHHHHCCCCC	55.89	21890473
1288	Ubiquitination	PPEMELLKFFRPENI CCCCHHHHHHCCCCC	55.89	21890473
1288	Ubiquitination	PPEMELLKFFRPENI CCCCHHHHHHCCCCC	55.89	22817900
1288 (in isoform 1)	Ubiquitination	-	55.89	21890473
1289	Ubiquitination	PEMELLKFFRPENIT CCCHHHHHHCCCCCE	6.74	21890473
1296	Phosphorylation	FFRPENITVSSRPSV HHCCCCCEECCCCCH	26.39	29514088
1298	Phosphorylation	RPENITVSSRPSVEQ CCCCCEECCCCCHHH	16.39	29514088
1299	Phosphorylation	PENITVSSRPSVEQL CCCCEECCCCCHHHH	43.82	29514088
1302	Phosphorylation	ITVSSRPSVEQLSSL CEECCCCCHHHHHHH	36.86	29514088
1307	Phosphorylation	RPSVEQLSSLIKTSL CCCHHHHHHHHHHHH	23.85	21406692
1308	Phosphorylation	PSVEQLSSLIKTSLH CCHHHHHHHHHHHHC	42.58	24719451
1311	Ubiquitination	EQLSSLIKTSLHYPE HHHHHHHHHHHCCCH	37.04	29967540
1342	Phosphorylation	TLLLSNCSKADVDVI HHHHHCCCCCCCCEE	34.82	-
1381	Ubiquitination	TQYKLQLKSQEIHSL CEEEEEECHHHHHHC	36.81	29967540
1433	Phosphorylation	MPALIIISNV----- CCEEEEEECC-----	22.56	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TPPC8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TPPC8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TPPC8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TPPC3_HUMAN	TRAPPC3	physical	21453443
TPC13_HUMAN	TRAPPC13	physical	21453443
TPC11_HUMAN	TRAPPC11	physical	21525244
TPC12_HUMAN	TRAPPC12	physical	21525244
TPC10_HUMAN	TRAPPC10	physical	21525244
TPPC3_HUMAN	TRAPPC3	physical	21525244
TPC2L_HUMAN	TRAPPC2L	physical	21525244
TPC2A_HUMAN	TRAPPC2	physical	21525244
TPC2B_HUMAN	TRAPPC2	physical	21525244
TPPC4_HUMAN	TRAPPC4	physical	21525244
TPPC8_HUMAN	TRAPPC8	physical	21525244
TPPC9_HUMAN	TRAPPC9	physical	21525244
TPC6B_HUMAN	TRAPPC6B	physical	21525244

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-584, AND MASSSPECTROMETRY.
PubMed: 18083107