CNTN4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CNTN4_HUMAN
• UniProt AC: Q8IWV2
• Protein Name: Contactin-4
• Gene Name: CNTN4
• Organism: Homo sapiens (Human).
• Sequence Length: 1026
• Subcellular Localization: Cell membrane; Lipid-anchor, GPI-anchor. Secreted.
• Protein Description: Contactins mediate cell surface interactions during nervous system development. Has some neurite outgrowth-promoting activity. May be involved in synaptogenesis..
• Protein Sequence: MRLPWELLVLQSFILCLADDSTLHGPIFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSVVEGSLLINNPNKTQDAGTYQCTATNSFGTIVSREAKLQFAYLDNFKTRTRSTVSVRRGQGMVLLCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTCVVTNTVTNHKVLGPPTPLILRNDGVMGEYEPKIEVQFPETVPTAKGATVKLECFALGNPVPTIIWRRADGKPIARKARRHKSNGILEIPNFQQEDAGLYECVAENSRGKNVARGQLTFYAQPNWIQKINDIHVAMEENVFWECKANGRPKPTYKWLKNGEPLLTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTLLKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRIINVTKSDAGSYTCIATNHFGTASSTGNLVVKDPTRVMVPPSSMDVTVGESIVLPCQVTHDHSLDIVFTWSFNGHLIDFDRDGDHFERVGGQDSAGDLMIRNIQLKHAGKYVCMVQTSVDRLSAAADLIVRGPPGPPEAVTIDEITDTTAQLSWRPGPDNHSPITMYVIQARTPFSVGWQAVSTVPELIDGKTFTATVVGLNPWVEYEFRTVAANVIGIGEPSRPSEKRRTEEALPEVTPANVSGGGGSKSELVITWETVPEELQNGRGFGYVVAFRPYGKMIWMLTVLASADASRYVFRNESVHPFSPFEVKVGVFNNKGEGPFSPTTVVYSAEEEPTKPPASIFARSLSATDIEVFWASPLEKNRGRIQGYEVKYWRHEDKEENARKIRTVGNQTSTKITNLKGSVLYHLAVKAYNSAGTGPSSATVNVTTRKPPPSQPPGNIIWNSSDSKIILNWDQVKALDNESEVKGYKVLYRWNRQSSTSVIETNKTSVELSLPFDEDYIIEIKPFSDGGDGSSSEQIRIPKISNAYARGSGASTSNACTLSAISTIMISLTARSSL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
65	N-linked_Glycosylation	PHIRWKLNGTDVDTG CCEEEEECCEECCCC	47.82	16335952
90	N-linked_Glycosylation	SLLINNPNKTQDAGT CEEECCCCCCCCCEE	63.23	UniProtKB CARBOHYD
131	Phosphorylation	FKTRTRSTVSVRRGQ CCCCCCCEEEEECCC	17.32	-
176	Phosphorylation	RRFVSQETGNLYIAK CCEEECCCCCEEEEE	24.59	-
180	Phosphorylation	SQETGNLYIAKVEKS ECCCCCEEEEEEEEC	11.66	-
191	N-linked_Glycosylation	VEKSDVGNYTCVVTN EEECCCCCEEEEEEE	28.87	UniProtKB CARBOHYD
223	Phosphorylation	NDGVMGEYEPKIEVQ CCCCCCCCCCCEEEE	31.63	-
370	N-linked_Glycosylation	QIEQGTLNITIVNLS EEECCEEEEEEEEHH	29.24	UniProtKB CARBOHYD
375	N-linked_Glycosylation	TLNITIVNLSDAGMY EEEEEEEEHHHCCHH	29.94	UniProtKB CARBOHYD
466	N-linked_Glycosylation	DGNLRIINVTKSDAG CCCEEEEEEECCCCC	32.79	UniProtKB CARBOHYD
474	Phosphorylation	VTKSDAGSYTCIATN EECCCCCCEEEEEEC	20.99	-
476	Phosphorylation	KSDAGSYTCIATNHF CCCCCCEEEEEECCC	10.11	-
487	Phosphorylation	TNHFGTASSTGNLVV ECCCCCCCCCCCEEE	28.42	-
616	Phosphorylation	TDTTAQLSWRPGPDN CCCEEECCCCCCCCC	14.68	24719451
705	N-linked_Glycosylation	LPEVTPANVSGGGGS CCCCCCCCCCCCCCC	29.68	UniProtKB CARBOHYD
764	N-linked_Glycosylation	ASRYVFRNESVHPFS HHHEEECCCCCCCCC	34.14	UniProtKB CARBOHYD
824	Phosphorylation	DIEVFWASPLEKNRG CEEEEEECCCHHCCC	22.18	24719451
855	Phosphorylation	ENARKIRTVGNQTST HHHHEEEECCCCCCC	35.92	19651622
858	N-linked_Glycosylation	RKIRTVGNQTSTKIT HEEEECCCCCCCEEE	37.31	UniProtKB CARBOHYD
862	Phosphorylation	TVGNQTSTKITNLKG ECCCCCCCEEECCCC	29.83	19651622
893	N-linked_Glycosylation	GPSSATVNVTTRKPP CCCCCEEEEEECCCC	22.51	UniProtKB CARBOHYD
911	N-linked_Glycosylation	PPGNIIWNSSDSKII CCCCEEECCCCCEEE	22.64	UniProtKB CARBOHYD
929	N-linked_Glycosylation	DQVKALDNESEVKGY HHEEECCCHHHHCCE	56.39	UniProtKB CARBOHYD
954	N-linked_Glycosylation	STSVIETNKTSVELS CCEEEECCCCEEEEE	32.58	UniProtKB CARBOHYD
1000	GPI-anchor	SNAYARGSGASTSNA CCCCCCCCCCCCCCC	26.15	-
1015	Phosphorylation	CTLSAISTIMISLTA HHHHHHHHHHHHHHH	14.40	-
1021	Phosphorylation	STIMISLTARSSL-- HHHHHHHHHHHCC--	17.15	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CNTN4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CNTN4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CNTN4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CNTN4_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

N-linked Glycosylation

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction,hydrazide chemistry, and mass spectrometry.";
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E.,Moore R.J., Smith R.D.;
J. Proteome Res. 4:2070-2080(2005).
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-65, AND MASS SPECTROMETRY.
PubMed: 16335952