AKIP1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKIP1_HUMAN
• UniProt AC: Q9NQ31
• Protein Name: A-kinase-interacting protein 1
• Gene Name: AKIP1
• Organism: Homo sapiens (Human).
• Sequence Length: 210
• Subcellular Localization: Nucleus . Locates to punctate spots.
• Protein Description: Enhances NF-kappa-B transcriptional activity by regulating the nuclear localization of the NF-kappa-B subunit RELA and promoting the phosphorylation of RELA by PRKACA. Regulates the effect of the cAMP-dependent protein kinase signaling pathway on the NF-kappa-B activation cascade..
• Protein Sequence: MDNCLAAAALNGVDRRSLQRSARLALEVLERAKRRAVDWHALERPKGCMGVLAREAPHLEKQPAAGPQRVLPGEREERPPTLSASFRTMAEFMDYTSSQCGKYYSSVPEEGGATHVYRYHRGESKLHMCLDIGNGQRKDRKKTSLGPGGSYQISEHAPEASQPAENISKDLYIEVYPGTYSVTVGSNDLTKKTHVVAVDSGQSVDLVFPV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Sumoylation	LEVLERAKRRAVDWH HHHHHHHHHHCCCHH	48.95	-
46	Ubiquitination	WHALERPKGCMGVLA HHHHHCCCCHHHHHH	71.60	-
46 (in isoform 3)	Ubiquitination	-	71.60	-
61	Ubiquitination	REAPHLEKQPAAGPQ CCCCCHHCCCCCCCC	68.86	-
61 (in isoform 3)	Ubiquitination	-	68.86	-
75 (in isoform 3)	Ubiquitination	-	57.92	-
76 (in isoform 3)	Phosphorylation	-	54.80	29496907
87 (in isoform 3)	Phosphorylation	-	22.54	27259358
103	Phosphorylation	TSSQCGKYYSSVPEE CHHHCCCEEECCCCC	8.21	27642862
117	Phosphorylation	EGGATHVYRYHRGES CCCCCEEEEEECCCC	9.61	27642862
142	Ubiquitination	GQRKDRKKTSLGPGG CCCCCCCCCCCCCCC	44.21	-
144	Phosphorylation	RKDRKKTSLGPGGSY CCCCCCCCCCCCCCC	39.96	28555341
150	Phosphorylation	TSLGPGGSYQISEHA CCCCCCCCCCCHHCC	21.56	28555341
151	Phosphorylation	SLGPGGSYQISEHAP CCCCCCCCCCHHCCC	17.09	28555341
190	Phosphorylation	TVGSNDLTKKTHVVA EECCCCCCCCEEEEE	33.10	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKIP1_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKIP1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKIP1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
KAPCA_HUMAN	PRKACA	physical	15630084
TF65_HUMAN	RELA	physical	16998474
SIR1_HUMAN	SIRT1	physical	16998474
SENP8_HUMAN	SENP8	physical	16998474

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.