| UniProt ID | HELQ_HUMAN | |
|---|---|---|
| UniProt AC | Q8TDG4 | |
| Protein Name | Helicase POLQ-like | |
| Gene Name | HELQ | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 1101 | |
| Subcellular Localization | ||
| Protein Description | Single-stranded DNA-dependent ATPase and 5' to 3' DNA helicase. [PubMed: 11751861 Involved in the repair of DNA cross-links and double-strand break (DSB) resistance. Participates in FANCD2-mediated repair. Forms a complex with POLN polymerase that participates in homologous recombination (HR) repair and is essential for cellular protection against DNA cross-links] | |
| Protein Sequence | MDECGSRIRRRVSLPKRNRPSLGCIFGAPTAAELVPGDEGKEEEEMVAENRRRKTAGVLPVEVQPLLLSDSPECLVLGGGDTNPDLLRHMPTDRGVGDQPNDSEVDMFGDYDSFTENSFIAQVDDLEQKYMQLPEHKKHATDFATENLCSESIKNKLSITTIGNLTELQTDKHTENQSGYEGVTIEPGADLLYDVPSSQAIYFENLQNSSNDLGDHSMKERDWKSSSHNTVNEELPHNCIEQPQQNDESSSKVRTSSDMNRRKSIKDHLKNAMTGNAKAQTPIFSRSKQLKDTLLSEEINVAKKTVESSSNDLGPFYSLPSKVRDLYAQFKGIEKLYEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIVQEKISGLSSFGIELGFFVEEYAGSKGRFPPTKRREKKSLYIATIEKGHSLVNSLIETGRIDSLGLVVVDELHMIGEGSRGATLEMTLAKILYTSKTTQIIGMSATLNNVEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYEVDSKAENGMTFSRLLNYKYSDTLKKMDPDHLVALVTEVIPNYSCLVFCPSKKNCENVAEMICKFLSKEYLKHKEKEKCEVIKNLKNIGNGNLCPVLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYVAKEFLKRNQYKQMIGRAGRAGIDTIGESILILQEKDKQQVLELITKPLENCYSHLVQEFTKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQKVLLKEKSLWEITVESLRYLTEKGLLQKDTIYKSEEEVQYNFHITKLGRASFKGTIDLAYCDILYRDLKKGLEGLVLESLLHLIYLTTPYDLVSQCNPDWMIYFRQFSQLSPAEQNVAAILGVSESFIGKKASGQAIGKKVDKNVVNRLYLSFVLYTLLKETNIWTVSEKFNMPRGYIQNLLTGTASFSSCVLHFCEELEEFWVYRALLVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTIDHLSRRQAKQIVSSAKMLLHEKAEALQEEVEELLRLPSDFPGAVASSTDKA | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 13 | Phosphorylation | SRIRRRVSLPKRNRP HHHHHHHCCCCCCCC | 36.82 | 26270265 | |
| 130 | Phosphorylation | VDDLEQKYMQLPEHK HHHHHHHHHCCHHHH | 6.98 | 28674419 | |
| 160 | Phosphorylation | IKNKLSITTIGNLTE HHHCCCEEEECCCCE | 14.69 | 28555341 | |
| 250 | Phosphorylation | PQQNDESSSKVRTSS CCCCCCCCCCCCCCH | 31.93 | 22210691 | |
| 281 | Phosphorylation | TGNAKAQTPIFSRSK HCCCCCCCCCCCCCH | 24.18 | 28555341 | |
| 285 | Phosphorylation | KAQTPIFSRSKQLKD CCCCCCCCCCHHHHH | 36.04 | - | |
| 318 | Phosphorylation | NDLGPFYSLPSKVRD CCCCCCCCCCHHHHH | 33.90 | 29802988 | |
| 321 | Phosphorylation | GPFYSLPSKVRDLYA CCCCCCCHHHHHHHH | 49.42 | 24719451 | |
| 425 | O-linked_Glycosylation | SKGRFPPTKRREKKS CCCCCCCCCHHCCCC | 37.10 | 30379171 | |
| 480 | Phosphorylation | RGATLEMTLAKILYT CCCCHHHHHHHHHHH | 17.75 | 24719451 | |
| 486 | Phosphorylation | MTLAKILYTSKTTQI HHHHHHHHHCCCCEE | 16.67 | 25278378 | |
| 487 | Phosphorylation | TLAKILYTSKTTQII HHHHHHHHCCCCEEE | 21.94 | 25278378 | |
| 488 | Phosphorylation | LAKILYTSKTTQIIG HHHHHHHCCCCEEEE | 17.91 | 25278378 | |
| 529 | Acetylation | VELKEYLKINDTIYE CCHHHHHCCCCEEEE | 38.26 | 7710457 | |
| 554 | Acetylation | FSRLLNYKYSDTLKK HHHHHCCCCCHHHHH | 36.89 | 7710465 | |
| 633 | Ubiquitination | GNLCPVLKRTIPFGV CCCCHHHHCCCCCCH | 47.97 | - | |
| 701 | Phosphorylation | EFLKRNQYKQMIGRA HHHHHHHHHHHHHHC | 13.51 | - | |
| 702 | Ubiquitination | FLKRNQYKQMIGRAG HHHHHHHHHHHHHCC | 24.51 | - | |
| 760 | Phosphorylation | GIQTLFLSLIGLKIA HHHHHHHHHHCHHHH | 15.59 | 22199227 | |
| 799 | Phosphorylation | EKSLWEITVESLRYL CCCHHHHHHHHHHHH | 13.50 | 23401153 | |
| 805 | Phosphorylation | ITVESLRYLTEKGLL HHHHHHHHHHHCCCC | 24.22 | 23401153 | |
| 816 | Phosphorylation | KGLLQKDTIYKSEEE CCCCCCCCCCCCHHH | 32.99 | - | |
| 818 | Phosphorylation | LLQKDTIYKSEEEVQ CCCCCCCCCCHHHHH | 15.56 | 22817900 | |
| 820 | Phosphorylation | QKDTIYKSEEEVQYN CCCCCCCCHHHHHEE | 33.01 | - | |
| 837 | Phosphorylation | ITKLGRASFKGTIDL EEECCCCCCCCCEEH | 26.57 | 24719451 | |
| 936 | Phosphorylation | KNVVNRLYLSFVLYT HHHHHHHHHHHHHHH | 9.32 | 20049867 | |
| 942 | Phosphorylation | LYLSFVLYTLLKETN HHHHHHHHHHHHHCC | 7.05 | - | |
| 1003 | Phosphorylation | VELTKKLTYCVKAEL HHHHHHHHHHHHHHH | 24.61 | 26074081 | |
| 1004 | Phosphorylation | ELTKKLTYCVKAELI HHHHHHHHHHHHHHH | 12.99 | 26074081 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of HELQ_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of HELQ_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of HELQ_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| DPOLN_HUMAN | POLN | physical | 19995904 | |
| ATR_HUMAN | ATR | physical | 24005329 | |
| RFA1_HUMAN | RPA1 | physical | 24005329 | |
| RA51B_HUMAN | RAD51B | physical | 24005329 | |
| RA51C_HUMAN | RAD51C | physical | 24005329 | |
| RA51D_HUMAN | RAD51D | physical | 24005329 | |
| XRCC2_HUMAN | XRCC2 | physical | 24005329 | |
| FACD2_HUMAN | FANCD2 | physical | 24005329 | |
| FANCI_HUMAN | FANCI | physical | 24005329 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| OMIM Disease | ||||||
| There are no disease associations of PTM sites. | ||||||
| Kegg Drug | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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