CLD17_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CLD17_HUMAN
• UniProt AC: P56750
• Protein Name: Claudin-17
• Gene Name: CLDN17
• Organism: Homo sapiens (Human).
• Sequence Length: 224
• Subcellular Localization: Cell junction, tight junction . Cell membrane ; Multi-pass membrane protein .
• Protein Description: Channel-forming tight junction protein with selectivity for anions, including chloride and bicarbonate, and for solutes smaller than 9 Angstrom in diameter. In the kidney proximal tubule, may be involved in quantitative reabsorption of filtered anions. Does not affect water permeability..
• Protein Sequence: MAFYPLQIAGLVLGFLGMVGTLATTLLPQWRVSAFVGSNIIVFERLWEGLWMNCIRQARVRLQCKFYSSLLALPPALETARALMCVAVALSLIALLIGICGMKQVQCTGSNERAKAYLLGTSGVLFILTGIFVLIPVSWTANIIIRDFYNPAIHIGQKRELGAALFLGWASAAVLFIGGGLLCGFCCCNRKKQGYRYPVPGYRVPHTDKRRNTTMLSKTSTSYV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
38	Phosphorylation	RVSAFVGSNIIVFER HHEEECCCCEEEEEH	21.39	-
202	Phosphorylation	YRYPVPGYRVPHTDK CCCCCCCCCCCCCCC	11.45	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	LNX1	Q8TBB1	PMID:22889411

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CLD17_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CLD17_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CLD17_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.