AK1BF_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AK1BF_HUMAN
• UniProt AC: C9JRZ8
• Protein Name: Aldo-keto reductase family 1 member B15 {ECO:0000305}
• Gene Name: AKR1B15 {ECO:0000312|HGNC:HGNC:37281}
• Organism: Homo sapiens (Human).
• Sequence Length: 316
• Subcellular Localization: Isoform 1: Mitochondrion .; Isoform 2: Cytoplasm, cytosol .
• Protein Description: Isoform 1: Mainly acts as a reductive enzyme that catalyzes the reduction of androgens and estrogens with high positional selectivity (shows 17-beta-hydroxysteroid dehydrogenase activity) as well as 3-keto-acyl-CoAs. Has a strong selectivity towards NADP(H). [PubMed: 25577493; Isoform 2: No oxidoreductase activity observed with the tested substrates.]
• Protein Sequence: MATFVELSTKAKMPIVGLGTWRSLLGKVKEAVKVAIDAEYRHIDCAYFYENQHEVGEAIQEKIQEKAVMREDLFIVSKVWPTFFERPLVRKAFEKTLKDLKLSYLDVYLIHWPQGFKTGDDFFPKDDKGNMISGKGTFLDAWEAMEELVDEGLVKALGVSNFNHFQIERLLNKPGLKYKPVTNQVECHPYLTQEKLIQYCHSKGITVTAYSPLGSPDRPWAKPEDPSLLEDPKIKEIAAKHKKTTAQVLIRFHIQRNVTVIPKSMTPAHIVENIQVFDFKLSDEEMATILSFNRNWRAFDFKEFSHLEDFPFDAEY

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
8	Phosphorylation	MATFVELSTKAKMPI CCCEEECCCCCCCCE	33.45	22617229
9	Phosphorylation	ATFVELSTKAKMPIV CCEEECCCCCCCCEE	10.01	22210691
10	Ubiquitination	TFVELSTKAKMPIVG CEEECCCCCCCCEEE	37.56	29901268
20	Phosphorylation	MPIVGLGTWRSLLGK CCEEEHHHHHHHHHH	14.12	20068231
70	Methylation	IQEKAVMREDLFIVS HHHHHHHCCCEEEEE	21.24	-
95	Acetylation	LVRKAFEKTLKDLKL HHHHHHHHHHHHHCH	10.29	19819977
95	Ubiquitination	LVRKAFEKTLKDLKL HHHHHHHHHHHHHCH	10.29	33845483
101	Ubiquitination	EKTLKDLKLSYLDVY HHHHHHHCHHHEEEE	2.43	33845483
103	Phosphorylation	TLKDLKLSYLDVYLI HHHHHCHHHEEEEEE	4.43	28857561
117	Acetylation	IHWPQGFKTGDDFFP ECCCCCCCCCCCCCC	6.99	19819983
123	Ubiquitination	FKTGDDFFPKDDKGN CCCCCCCCCCCCCCC	53.34	33845483
125	Acetylation	TGDDFFPKDDKGNMI CCCCCCCCCCCCCCC	6.35	-
129	Ubiquitination	FFPKDDKGNMISGKG CCCCCCCCCCCCCCC	45.58	33845483
173	Ubiquitination	QIERLLNKPGLKYKP HHHHHHCCCCCCCCC	2.52	-
177	Ubiquitination	LLNKPGLKYKPVTNQ HHCCCCCCCCCCCCC	7.72	-
179	Acetylation	NKPGLKYKPVTNQVE CCCCCCCCCCCCCEE	47.12	-
190	Phosphorylation	NQVECHPYLTQEKLI CCEECCCCCCHHHHH	6.14	-
195	Ubiquitination	HPYLTQEKLIQYCHS CCCCCHHHHHHHHHH	3.04	33845483
199	Phosphorylation	TQEKLIQYCHSKGIT CHHHHHHHHHHCCCE	10.96	-
206	Phosphorylation	YCHSKGITVTAYSPL HHHHCCCEEEEECCC	26.10	20071362
211	Phosphorylation	GITVTAYSPLGSPDR CCEEEEECCCCCCCC	44.10	-
215	Phosphorylation	TAYSPLGSPDRPWAK EEECCCCCCCCCCCC	4.04	20873877
222	Ubiquitination	SPDRPWAKPEDPSLL CCCCCCCCCCCHHHH	44.59	33845483
223	Ubiquitination	PDRPWAKPEDPSLLE CCCCCCCCCCHHHHC	40.86	33845483
227	Phosphorylation	WAKPEDPSLLEDPKI CCCCCCHHHHCCHHH	5.78	26657352
244	Phosphorylation	IAAKHKKTTAQVLIR HHHHCCCCCHHHHHH	39.57	26437602
245	Phosphorylation	AAKHKKTTAQVLIRF HHHCCCCCHHHHHHH	71.60	26437602
250	Ubiquitination	KTTAQVLIRFHIQRN CCCHHHHHHHHHHCC	45.10	33845483
263	Acetylation	RNVTVIPKSMTPAHI CCEEEECCCCCHHHH	49.55	-
282	Phosphorylation	QVFDFKLSDEEMATI EEEEEECCHHHHHHH	3.65	68744639
288	Phosphorylation	LSDEEMATILSFNRN CCHHHHHHHHHCCCC	6.50	20068231
291	Phosphorylation	EEMATILSFNRNWRA HHHHHHHHCCCCCCC	41.56	20068231

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AK1BF_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AK1BF_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AK1BF_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of AK1BF_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.