UB2L6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: UB2L6_HUMAN
• UniProt AC: O14933
• Protein Name: Ubiquitin/ISG15-conjugating enzyme E2 L6
• Gene Name: UBE2L6
• Organism: Homo sapiens (Human).
• Sequence Length: 153
• Protein Description: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3..
• Protein Sequence: MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MMASMRVVKEL ----CCCCHHHHHHH	6.82	25690035
9	Ubiquitination	MASMRVVKELEDLQK CCCHHHHHHHHHHHH	54.44	29967540
16	Ubiquitination	KELEDLQKKPPPYLR HHHHHHHHCCCCCHH	74.64	24816145
17	Ubiquitination	ELEDLQKKPPPYLRN HHHHHHHCCCCCHHC	50.20	32142685
26	Phosphorylation	PPYLRNLSSDDANVL CCCHHCCCHHHHCHH	34.96	25884760
27	Phosphorylation	PYLRNLSSDDANVLV CCHHCCCHHHHCHHH	42.55	28450419
30	Ubiquitination	RNLSSDDANVLVWHA HCCCHHHHCHHHEEE	17.02	29967540
49	Ubiquitination	DQPPYHLKAFNLRIS CCCCCEEEEEEEEEE	37.30	33845483
72	Ubiquitination	PPMIKFTTKIYHPNV CCEEEEEECCCCCCC	20.69	24816145
96	Ubiquitination	IISSENWKPCTKTCQ EECCCCCCCCCHHHH	41.62	29967540
96	Acetylation	IISSENWKPCTKTCQ EECCCCCCCCCHHHH	41.62	25953088
123	Sulfoxidation	NIREPLRMDLADLLT CCCCCCCCCHHHHHH	6.97	21406390
138	Acetylation	QNPELFRKNAEEFTL HCHHHHHHCHHHHEH	53.85	7662295
138	Ubiquitination	QNPELFRKNAEEFTL HCHHHHHHCHHHHEH	53.85	24816145
144	Phosphorylation	RKNAEEFTLRFGVDR HHCHHHHEHHCCCCC	21.94	24719451
153	Phosphorylation	RFGVDRPS------- HCCCCCCC-------	54.47	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of UB2L6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of UB2L6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of UB2L6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI25_HUMAN	TRIM25	physical	12075357
MUL1_HUMAN	MUL1	physical	19690564
R144B_HUMAN	RNF144B	physical	19690564
M3K1_HUMAN	MAP3K1	physical	19690564
PJA2_HUMAN	PJA2	physical	19690564
RN122_HUMAN	RNF122	physical	19690564
RN150_HUMAN	RNF150	physical	19690564
RNF25_HUMAN	RNF25	physical	19690564
RNF4_HUMAN	RNF4	physical	19690564
TOPRS_HUMAN	TOPORS	physical	19690564
RN125_HUMAN	RNF125	physical	19549727
TRAF7_HUMAN	TRAF7	physical	19549727
DTX3_HUMAN	DTX3	physical	19549727
ARI2_HUMAN	ARIH2	physical	19549727
R144B_HUMAN	RNF144B	physical	19549727
R144A_HUMAN	RNF144A	physical	19549727
HOIL1_HUMAN	RBCK1	physical	19549727
LONF1_HUMAN	LONRF1	physical	19549727
TRIM8_HUMAN	TRIM8	physical	19549727
CBLC_HUMAN	CBLC	physical	19549727
TRI27_HUMAN	TRIM27	physical	19549727
RUNX1_HUMAN	RUNX1	physical	18073335
SIAH1_HUMAN	SIAH1	physical	18073335
GDIR1_HUMAN	ARHGDIA	physical	21900206
FLT3_HUMAN	FLT3	physical	20508617
MINT_HUMAN	SPEN	physical	16583136
ARI2_HUMAN	ARIH2	physical	22037423
ARI1_HUMAN	ARIH1	physical	22037423
TIM8A_HUMAN	TIMM8A	physical	22037423
R144A_HUMAN	RNF144A	physical	11722579
HOIL1_MOUSE	Rbck1	physical	11722579
ARI2_MOUSE	Arih2	physical	11722579
UB2L6_HUMAN	UBE2L6	physical	20061386
ARI2_HUMAN	ARIH2	physical	25416956
HOIL1_HUMAN	RBCK1	physical	25416956
LONF1_HUMAN	LONRF1	physical	25416956
UBE3A_HUMAN	UBE3A	physical	9153201

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.