ARI2_MOUSE - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ARI2_MOUSE
• UniProt AC: Q9Z1K6
• Protein Name: E3 ubiquitin-protein ligase ARIH2
• Gene Name: Arih2
• Organism: Mus musculus (Mouse).
• Sequence Length: 492
• Subcellular Localization: Nucleus . Cytoplasm .
• Protein Description: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (By similarity). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex. Mediates 'Lys-6', 'Lys-48'-and 'Lys-63'-linked polyubiquitination. May play a role in myelopoiesis (By similarity)..
• Protein Sequence: MSVDMNSQGSDSNEEDYDPNCEEEEEEEEDPGDIEDYYVGVASDVEQQGADAFDPEEYQFTCLTYKESEGALHEHMTSLASVLKVSHSVAKLILVNFHWQVSEILDRYRSNSAQLLVEARVQPNPSKHVPTAHPPHHCAVCMQFVRKENLLSLACQHQFCRSCWEQHCSVLVKDGVGVGISCMAQDCPLRTPEDFVFPLLPNEELRDKYRRYLFRDYVESHFQLQLCPGADCPMVIRVQEPRARRVQCNRCSEVFCFKCRQMYHAPTDCATIRKWLTKCADDSETANYISAHTKDCPKCNICIEKNGGCNHMQCSKCKHDFCWMCLGDWKTHGSEYYECSRYKENPDIVNQSQQAQAREALKKYLFYFERWENHNKSLQLEAQTYERIHEKIQERVMNNLGTWIDWQYLQNAAKLLAKCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLKDFHDT

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
337	Phosphorylation	KTHGSEYYECSRYKE CCCCCCCCCCCCCCC	13.35	29514104
352	Phosphorylation	NPDIVNQSQQAQARE CCCCCCHHHHHHHHH	21.03	22817900
376	Ubiquitination	ERWENHNKSLQLEAQ HHHHHCCHHHHHHHH	45.02	-
418	Ubiquitination	NAAKLLAKCRYTLQY HHHHHHHHHCCEEEE	21.15	-
459	Ubiquitination	EIENLSWKVERADSY HHHHHCEEEEECCCC	30.73	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ARI2_MOUSE !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ARI2_MOUSE !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ARI2_MOUSE !!

Protein-Protein Interaction

Oops, there are no PPI records of ARI2_MOUSE !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.