TRI34_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TRI34_HUMAN
• UniProt AC: Q9BYJ4
• Protein Name: Tripartite motif-containing protein 34
• Gene Name: TRIM34
• Organism: Homo sapiens (Human).
• Sequence Length: 488
• Subcellular Localization: Cytoplasm .
• Protein Description: May function as antiviral protein and may contribute to the defense against retroviral infections..
• Protein Sequence: MASKILLNVQEEVTCPICLELLTEPLSLDCGHSLCRACITVSNKEAVTSMGGKSSCPVCGISYSFEHLQANQHLANIVERLKEVKLSPDNGKKRDLCDHHGEKLLLFCKEDRKVICWLCERSQEHRGHHTVLTEEVFKECQEKLQAVLKRLKKEEEEAEKLEADIREEKTSWKYQVQTERQRIQTEFDQLRSILNNEEQRELQRLEEEEKKTLDKFAEAEDELVQQKQLVRELISDVECRSQWSTMELLQDMSGIMKWSEIWRLKKPKMVSKKLKTVFHAPDLSRMLQMFRELTAVRCYWVDVTLNSVNLNLNLVLSEDQRQVISVPIWPFQCYNYGVLGSQYFSSGKHYWEVDVSKKTAWILGVYCRTYSRHMKYVVRRCANRQNLYTKYRPLFGYWVIGLQNKCKYGVFEESLSSDPEVLTLSMAVPPCRVGVFLDYEAGIVSFFNVTSHGSLIYKFSKCCFSQPVYPYFNPWNCPAPMTLCPPSS

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
44	Ubiquitination	ACITVSNKEAVTSMG HHEEECCHHHHHCCC	39.27	-
82	Ubiquitination	ANIVERLKEVKLSPD HHHHHHHHHCCCCCC	67.68	-
85	Acetylation	VERLKEVKLSPDNGK HHHHHHCCCCCCCCC	44.32	7663103
87	Phosphorylation	RLKEVKLSPDNGKKR HHHHCCCCCCCCCCC	25.21	25056879
93	Acetylation	LSPDNGKKRDLCDHH CCCCCCCCCCCCCCC	53.17	7663111
93	Methylation	LSPDNGKKRDLCDHH CCCCCCCCCCCCCCC	53.17	7663111
103	Ubiquitination	LCDHHGEKLLLFCKE CCCCCCCEEEEEEEC	49.37	-
109	Ubiquitination	EKLLLFCKEDRKVIC CEEEEEEECCCEEEE	56.14	-
143	Ubiquitination	VFKECQEKLQAVLKR HHHHHHHHHHHHHHH	21.74	29967540
149	Ubiquitination	EKLQAVLKRLKKEEE HHHHHHHHHHHHHHH	49.43	29967540
169	Ubiquitination	EADIREEKTSWKYQV HHHHHHHHCCHHHHH	43.01	29967540
173	Ubiquitination	REEKTSWKYQVQTER HHHHCCHHHHHHHHH	26.10	22505724
185	Phosphorylation	TERQRIQTEFDQLRS HHHHHHHHHHHHHHH	35.93	-
215	Ubiquitination	EEKKTLDKFAEAEDE HHHHHHHHHHHHHHH	49.97	29967540
227	Ubiquitination	EDELVQQKQLVRELI HHHHHHHHHHHHHHH	28.63	21963094
227 (in isoform 1)	Ubiquitination	-	28.63	21906983
227 (in isoform 2)	Ubiquitination	-	28.63	21906983
235	Phosphorylation	QLVRELISDVECRSQ HHHHHHHHHHHHHHH	48.50	28450419
273	Acetylation	KPKMVSKKLKTVFHA CCHHHCHHHHHHHCC	47.94	22424773
275	Acetylation	KMVSKKLKTVFHAPD HHHCHHHHHHHCCCC	52.07	22424773
357	Ubiquitination	YWEVDVSKKTAWILG EEEEECCHHHHHHHH	54.73	-
358	Ubiquitination	WEVDVSKKTAWILGV EEEECCHHHHHHHHH	35.65	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TRI34_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TRI34_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TRI34_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRIM5_HUMAN	TRIM5	physical	16828831
TRI34_HUMAN	TRIM34	physical	21680743
TRIM5_HUMAN	TRIM5	physical	22493164
MKRN3_HUMAN	MKRN3	physical	22493164

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.