AKAP6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: AKAP6_HUMAN
• UniProt AC: Q13023
• Protein Name: A-kinase anchor protein 6
• Gene Name: AKAP6
• Organism: Homo sapiens (Human).
• Sequence Length: 2319
• Subcellular Localization: Sarcoplasmic reticulum. Nucleus membrane. In heart muscle. Participation of multiple targeting signals allow correct intracellular targeting. These may be repeated motifs rich in basic and hydrophobic amino acids, palmitoylated/myristoylated motifs o
• Protein Description: Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the nuclear membrane or sarcoplasmic reticulum. May act as an adapter for assembling multiprotein complexes..
• Protein Sequence: MLTMSVTLSPLRSQDLDPMATDASPMAINMTPTVEQGEGEEAMKDMDSDQQYEKPPPLHTGADWKIVLHLPEIETWLRMTSERVRDLTYSVQQDSDSKHVDVHLVQLKDICEDISDHVEQIHALLETEFSLKLLSYSVNVIVDIHAVQLLWHQLRVSVLVLRERILQGLQDANGNYTRQTDILQAFSEETKEGRLDSLTEVDDSGQLTIKCSQNYLSLDCGITAFELSDYSPSEDLLSGLGDMTSSQVKTKPFDSWSYSEMEKEFPELIRSVGLLTVAADSISTNGSEAVTEEVSQVSLSVDDKGGCEEDNASAVEEQPGLTLGVSSSSGEALTNAAQPSSETVQQESSSSSHHDAKNQQPVPCENATPKRTIRDCFNYNEDSPTQPTLPKRGLFLKEETFKNDLKGNGGKRQMVDLKPEMSRSTPSLVDPPDRSKLCLVLQSSYPNSPSAASQSYECLHKVGNGNLENTVKFHIKEISSSLGRLNDCYKEKSRLKKPHKTSEEVPPCRTPKRGTGSGKQAKNTKSSAVPNGELSYTSKAIEGPQTNSASTSSLEPCNQRSWNAKLQLQSETSSSPAFTQSSESSVGSDNIMSPVPLLSKHKSKKGQASSPSHVTRNGEVVEAWYGSDEYLALPSHLKQTEVLALKLENLTKLLPQKPRGETIQNIDDWELSEMNSDSEIYPTYHVKKKHTRLGRVSPSSSSDIASSLGESIESGPLSDILSDEESSMPLAGMKKYADEKSERASSSEKNESHSATKSALIQKLMQDIQHQDNYEAIWEKIEGFVNKLDEFIQWLNEAMETTENWTPPKAEMDDLKLYLETHLSFKLNVDSHCALKEAVEEEGHQLLELIASHKAGLKDMLRMIASQWKELQRQIKRQHSWILRALDTIKAEILATDVSVEDEEGTGSPKAEVQLCYLEAQRDAVEQMSLKLYSEQYTSSSKRKEEFADMSKVHSVGSNGLLDFDSEYQELWDWLIDMESLVMDSHDLMMSEEQQQHLYKRYSVEMSIRHLKKTELLSKVEALKKGGVLLPNDLLEKVDSINEKWELLGKTLGEKIQDTMAGHSGSSPRDLLSPESGSLVRQLEVRIKELKGWLRDTELFIFNSCLRQEKEGTMNTEKQLQYFKSLCREIKQRRRGVASILRLCQHLLDDRETCNLNADHQPMQLIIVNLERRWEAIVMQAVQWQTRLQKKMGKESETLNVIDPGLMDLNGMSEDALEWDEMDISNKLISLNEESNDLDQELQPVIPSLKLGETSNEDPGYDEEADNHGGSQYASNITAPSSPHIYQVYSLHNVELYEDNHMPFLKNNPKVTGMTQPNVLTKSLSKDSSFSSTKSLPDLLGGSNLVKPCACHGGDMSQNSGSESGIVSEGDTETTTNSEMCLLNAVDGSPSNLETEHLDPQMGDAVNVLKQKFTDEGESIKLPNSSQSSISPVGCVNGKVGDLNSITKHTPDCLGEELQGKHDVFTFYDYSYLQGSKLKLPMIMKQSQSEKAHVEDPLLRGFYFDKKSCKSKHQTTELQPDVPPHERILASASHEMDRISYKSGNIEKTFTGMQNAKQLSLLSHSSSIESLSPGGDLFGLGIFKNGSDSLQRSTSLESWLTSYKSNEDLFSCHSSGDISVSSGSVGELSKRTLDLLNRLENIQSPSEQKIKRSVSDITLQSSSQKMSFTGQMSLDIASSINEDSAASLTELSSSDELSLCSEDIVLHKNKIPESNASFRKRLTRSVADESDVNVSMIVNVSCTSACTDDEDDSDLLSSSTLTLTEEELCIKDEDDDSSIATDDEIYEDCTLMSGLDYIKNELQTWIRPKLSLTRDKKRCNVSDEMKGSKDISSSEMTNPSDTLNIETLLNGSVKRVSENNGNGKNSSHTHELGTKRENKKTIFKVNKDPYVADMENGNIEGIPERQKGKPNVTSKVSENLGSHGKEISESEHCKCKALMDSLDDSNTAGKEFVSQDVRHLPKKCPNHHHFENQSTASTPTEKSFSELALETRFNNRQDSDALKSSDDAPSMAGKSAGCCLALEQNGTEENASISNISCCNCEPDVFHQKDAEDCSVHNFVKEIIDMASTALKSKSQPENEVAAPTSLTQIKEKVLEHSHRPIQLRKGDFYSYLSLSSHDSDCGEVTNYIEEKSSTPLPLDTTDSGLDDKEDIECFFEACVEGDSDGEEPCFSSAPPNESAVPSEAAMPLQATACSSEFSDSSLSADDADTVALSSPSSQERAEVGKEVNGLPQTSSGCAENLEFTPSKLDSEKESSGKPGESGMPEEHNAASAKSKVQDLSLKANQPTDKAALHPSPKTLTCEENLLNLHEKRHRNMHR

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MLTMSVTLSPLRSQ -CCEEEEEECCCCCC	17.76	29632367
9	Phosphorylation	LTMSVTLSPLRSQDL CEEEEEECCCCCCCC	16.72	24719451
21	Phosphorylation	QDLDPMATDASPMAI CCCCCCCCCCCCCEE	26.33	22210691
31	Phosphorylation	SPMAINMTPTVEQGE CCCEECCCCCCCCCC	16.00	22210691
130	Phosphorylation	ALLETEFSLKLLSYS HHHHCHHHHHHHHCC	20.54	24719451
368	Phosphorylation	PVPCENATPKRTIRD CCCCCCCCCCCCHHH	40.71	29255136
370	Acetylation	PCENATPKRTIRDCF CCCCCCCCCCHHHHC	58.79	19829863
422	Phosphorylation	VDLKPEMSRSTPSLV EECCHHHCCCCCCCC	22.78	68711003
424	Phosphorylation	LKPEMSRSTPSLVDP CCHHHCCCCCCCCCC	37.05	26699800
425	Phosphorylation	KPEMSRSTPSLVDPP CHHHCCCCCCCCCCC	18.78	26699800
427	Phosphorylation	EMSRSTPSLVDPPDR HHCCCCCCCCCCCCH	40.90	27732954
455	Phosphorylation	SPSAASQSYECLHKV CCCHHHHHHHHHHHC	22.02	18852121
479	Phosphorylation	KFHIKEISSSLGRLN EEEHHHHHHHHCCHH	18.24	29255136
480	Phosphorylation	FHIKEISSSLGRLND EEHHHHHHHHCCHHH	34.93	26699800
481	Phosphorylation	HIKEISSSLGRLNDC EHHHHHHHHCCHHHH	28.22	29255136
510	Phosphorylation	EEVPPCRTPKRGTGS CCCCCCCCCCCCCCC	39.62	26657352
517	Phosphorylation	TPKRGTGSGKQAKNT CCCCCCCCCCCCCCC	42.53	26657352
536	Phosphorylation	VPNGELSYTSKAIEG CCCCCCCEEECCCCC	27.88	29759185
537	Phosphorylation	PNGELSYTSKAIEGP CCCCCCEEECCCCCC	22.00	29759185
574	O-linked_Glycosylation	QLQSETSSSPAFTQS EECCCCCCCCCCCCC	48.00	30379171
604	Methylation	LLSKHKSKKGQASSP CCCCCCCCCCCCCCC	66.77	-
609	Phosphorylation	KSKKGQASSPSHVTR CCCCCCCCCCCCCCC	34.59	27732954
610	Phosphorylation	SKKGQASSPSHVTRN CCCCCCCCCCCCCCC	33.18	26437602
612	Phosphorylation	KGQASSPSHVTRNGE CCCCCCCCCCCCCCC	32.32	27732954
615	Phosphorylation	ASSPSHVTRNGEVVE CCCCCCCCCCCCEEE	17.00	24732914
627	Phosphorylation	VVEAWYGSDEYLALP EEEEEECCCCEECCC	16.15	28842319
651	Phosphorylation	ALKLENLTKLLPQKP HHHHHHHHHHCCCCC	31.09	22817900
824	Phosphorylation	LYLETHLSFKLNVDS HHHHHHHHHCCCCCC	16.84	24719451
906	Phosphorylation	SVEDEEGTGSPKAEV CCCCCCCCCCCCCEE	37.45	26699800
908	Phosphorylation	EDEEGTGSPKAEVQL CCCCCCCCCCCEEEE	24.06	26699800
931	Ubiquitination	AVEQMSLKLYSEQYT HHHHHHHHHHHHHHC	37.76	-
1002	Phosphorylation	QQHLYKRYSVEMSIR HHHHHHHHCHHHHHH	16.96	141883
1003	Phosphorylation	QHLYKRYSVEMSIRH HHHHHHHCHHHHHHH	18.68	46161425
1007	Phosphorylation	KRYSVEMSIRHLKKT HHHCHHHHHHHHHHH	11.72	46161431
1051	Phosphorylation	KWELLGKTLGEKIQD HHHHHHHHHHHHHHH	37.89	46161461
1059	Phosphorylation	LGEKIQDTMAGHSGS HHHHHHHHHCCCCCC	7.79	46161467
1064	Phosphorylation	QDTMAGHSGSSPRDL HHHHCCCCCCCHHHH	39.18	27732954
1066	Phosphorylation	TMAGHSGSSPRDLLS HHCCCCCCCHHHHCC	39.94	27732954
1067	Phosphorylation	MAGHSGSSPRDLLSP HCCCCCCCHHHHCCC	27.72	25850435
1073	Phosphorylation	SSPRDLLSPESGSLV CCHHHHCCCCCCHHH	33.64	179979
1076	Phosphorylation	RDLLSPESGSLVRQL HHHCCCCCCHHHHHH	36.75	27732954
1078	Phosphorylation	LLSPESGSLVRQLEV HCCCCCCHHHHHHHH	32.73	29523821
1248	Phosphorylation	ELQPVIPSLKLGETS HHHCCCCCCCCCCCC	27.32	24719451
1325	Phosphorylation	NVLTKSLSKDSSFSS CCEECCCCCCCCCCC	41.32	46161443
1329	Phosphorylation	KSLSKDSSFSSTKSL CCCCCCCCCCCCCCC	39.00	26437602
1333	Phosphorylation	KDSSFSSTKSLPDLL CCCCCCCCCCCCHHH	24.37	46161473
1335	Phosphorylation	SSFSSTKSLPDLLGG CCCCCCCCCCHHHCC	45.27	46161449
1468	Phosphorylation	KHDVFTFYDYSYLQG CCCEEEEECHHHHCC	15.77	22817900
1470	Phosphorylation	DVFTFYDYSYLQGSK CEEEEECHHHHCCCC	6.45	22817900
1472	Phosphorylation	FTFYDYSYLQGSKLK EEEECHHHHCCCCCC	9.23	68707415
1533	Phosphorylation	ERILASASHEMDRIS HHHHHHHCCHHHHCC	19.93	50564403
1540	Phosphorylation	SHEMDRISYKSGNIE CCHHHHCCCCCCCHH	27.66	24719451
1560	Phosphorylation	MQNAKQLSLLSHSSS CCCHHHHHHHHCCCC	25.44	27732954
1563	Phosphorylation	AKQLSLLSHSSSIES HHHHHHHHCCCCCCC	26.98	27732954
1565	Phosphorylation	QLSLLSHSSSIESLS HHHHHHCCCCCCCCC	23.54	27732954
1566	Phosphorylation	LSLLSHSSSIESLSP HHHHHCCCCCCCCCC	29.88	27732954
1567	Phosphorylation	SLLSHSSSIESLSPG HHHHCCCCCCCCCCC	33.13	27732954
1570	Phosphorylation	SHSSSIESLSPGGDL HCCCCCCCCCCCCCC	32.26	27732954
1593	Phosphorylation	GSDSLQRSTSLESWL CCCCCCCCCCHHHHH	14.91	28857561
1594	Phosphorylation	SDSLQRSTSLESWLT CCCCCCCCCHHHHHH	39.25	28857561
1595	Phosphorylation	DSLQRSTSLESWLTS CCCCCCCCHHHHHHH	31.24	28857561
1644	Phosphorylation	NRLENIQSPSEQKIK HHHHCCCCCCHHHHH	26.96	25850435
1646	Phosphorylation	LENIQSPSEQKIKRS HHCCCCCCHHHHHHH	58.88	26699800
1653	Phosphorylation	SEQKIKRSVSDITLQ CHHHHHHHHHHHEEC	22.44	25850435
1655	Phosphorylation	QKIKRSVSDITLQSS HHHHHHHHHHEECCC	25.25	25850435
1658	Phosphorylation	KRSVSDITLQSSSQK HHHHHHHEECCCCCC	24.60	30206219
1661	Phosphorylation	VSDITLQSSSQKMSF HHHHEECCCCCCCCE	34.76	29759185
1662	Phosphorylation	SDITLQSSSQKMSFT HHHEECCCCCCCCEE	24.67	30206219
1663	Phosphorylation	DITLQSSSQKMSFTG HHEECCCCCCCCEEE	38.78	30206219
1717	Phosphorylation	KIPESNASFRKRLTR CCCCCCHHHHHHHHH	29.81	26437602
1811	Phosphorylation	TWIRPKLSLTRDKKR HHHCCCCCCCCCCCC	33.54	24719451
1837	Phosphorylation	DISSSEMTNPSDTLN CCCCCCCCCHHHCCC	39.67	18669648
1840	Phosphorylation	SSEMTNPSDTLNIET CCCCCCHHHCCCHHH	45.34	18669648
1857	Phosphorylation	NGSVKRVSENNGNGK HCCEEEEECCCCCCC	38.34	158737
1867	Phosphorylation	NGNGKNSSHTHELGT CCCCCCCCCCCCCCC	41.62	46161455
1941	Phosphorylation	KCKALMDSLDDSNTA HHHHHHHHCCCCCCC	21.52	9872953
1999	Phosphorylation	RFNNRQDSDALKSSD HCCCCCCHHHHHCCC	19.22	8342581
2068	O-linked_Glycosylation	KEIIDMASTALKSKS HHHHHHHHHHHHCCC	13.94	30379171
2068	Phosphorylation	KEIIDMASTALKSKS HHHHHHHHHHHHCCC	13.94	23403867
2069	O-linked_Glycosylation	EIIDMASTALKSKSQ HHHHHHHHHHHCCCC	26.86	30379171
2069	Phosphorylation	EIIDMASTALKSKSQ HHHHHHHHHHHCCCC	26.86	23403867
2098	Phosphorylation	KEKVLEHSHRPIQLR HHHHHHCCCCCEEEC	16.30	28674151
2255	Phosphorylation	KLDSEKESSGKPGES HCCCCCHHCCCCCCC	56.30	68719799
2256	Phosphorylation	LDSEKESSGKPGESG CCCCCHHCCCCCCCC	52.51	68719805
2262	Phosphorylation	SSGKPGESGMPEEHN HCCCCCCCCCCHHHC	46.43	68719811
2276	Ubiquitination	NAASAKSKVQDLSLK CHHHHHHHHHHHHHH	43.11	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of AKAP6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of AKAP6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of AKAP6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
PDE4A_HUMAN	PDE4A	physical	11296225

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.