PDE4A_HUMAN - dbPTM
PDE4A_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID PDE4A_HUMAN
UniProt AC P27815
Protein Name cAMP-specific 3',5'-cyclic phosphodiesterase 4A
Gene Name PDE4A
Organism Homo sapiens (Human).
Sequence Length 886
Subcellular Localization Isoform 1: Cytoplasm, perinuclear region.
Isoform 2: Cytoplasm, perinuclear region. Cell projection, ruffle membrane.
Isoform 4: Membrane
Peripheral membrane protein. Isoform 4 has propensity for association with membranes.
Isoform 6: Cytoplasm,
Protein Description Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes..
Protein Sequence MEPPTVPSERSLSLSLPGPREGQATLKPPPQHLWRQPRTPIRIQQRGYSDSAERAERERQPHRPIERADAMDTSDRPGLRTTRMSWPSSFHGTGTGSGGAGGGSSRRFEAENGPTPSPGRSPLDSQASPGLVLHAGAATSQRRESFLYRSDSDYDMSPKTMSRNSSVTSEAHAEDLIVTPFAQVLASLRSVRSNFSLLTNVPVPSNKRSPLGGPTPVCKATLSEETCQQLARETLEELDWCLEQLETMQTYRSVSEMASHKFKRMLNRELTHLSEMSRSGNQVSEYISTTFLDKQNEVEIPSPTMKEREKQQAPRPRPSQPPPPPVPHLQPMSQITGLKKLMHSNSLNNSNIPRFGVKTDQEELLAQELENLNKWGLNIFCVSDYAGGRSLTCIMYMIFQERDLLKKFRIPVDTMVTYMLTLEDHYHADVAYHNSLHAADVLQSTHVLLATPALDAVFTDLEILAALFAAAIHDVDHPGVSNQFLINTNSELALMYNDESVLENHHLAVGFKLLQEDNCDIFQNLSKRQRQSLRKMVIDMVLATDMSKHMTLLADLKTMVETKKVTSSGVLLLDNYSDRIQVLRNMVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDNRDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMAQEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAAKRACSACAGTFGEDTSALPAPGGGGSGGDPT
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
3 (in isoform 6)Phosphorylation-28.6722912867
6 (in isoform 7)Phosphorylation-6.3927251275
8PhosphorylationMEPPTVPSERSLSLS
CCCCCCCCCCCCCCC		41.11-
11PhosphorylationPTVPSERSLSLSLPG
CCCCCCCCCCCCCCC		20.4730266825
13PhosphorylationVPSERSLSLSLPGPR
CCCCCCCCCCCCCCC		19.7030266825
15PhosphorylationSERSLSLSLPGPREG
CCCCCCCCCCCCCCC		29.1930266825
21 (in isoform 7)Phosphorylation-59.8118669648
24 (in isoform 7)Phosphorylation-26.2518669648
44 (in isoform 2)Phosphorylation-19.6426657352
44 (in isoform 6)Phosphorylation-19.6422673903
46 (in isoform 6)Phosphorylation-29.6422673903
47 (in isoform 2)Phosphorylation-23.2026657352
48 (in isoform 2)Phosphorylation-16.1128152594
49PhosphorylationRIQQRGYSDSAERAE
CCHHCCCCCHHHHHH		28.1029802988
54 (in isoform 2)Phosphorylation-41.2729523821
55 (in isoform 7)Phosphorylation-16.2323879269
56 (in isoform 2)Phosphorylation-62.3929523821
58 (in isoform 2)Phosphorylation-47.3629523821
60 (in isoform 6)Phosphorylation-33.1422617229
68 (in isoform 2)Phosphorylation-8.9827251275
73PhosphorylationERADAMDTSDRPGLR
HHHHCCCCCCCCCCC		21.3125954137
77 (in isoform 7)Phosphorylation-51.6823879269
79 (in isoform 7)Phosphorylation-4.9523879269
85PhosphorylationGLRTTRMSWPSSFHG
CCCCCCCCCCCCCCC		32.3227080861
93PhosphorylationWPSSFHGTGTGSGGA
CCCCCCCCCCCCCCC		24.0125954137
95PhosphorylationSSFHGTGTGSGGAGG
CCCCCCCCCCCCCCC		28.1925954137
96PhosphorylationSFHGTGTGSGGAGGG
CCCCCCCCCCCCCCC		26.1633259812
97PhosphorylationFHGTGTGSGGAGGGS
CCCCCCCCCCCCCCC		33.6125954137
104PhosphorylationSGGAGGGSSRRFEAE
CCCCCCCCCCCCCCC		24.7725954137
105PhosphorylationGGAGGGSSRRFEAEN
CCCCCCCCCCCCCCC		30.6523532336
117PhosphorylationAENGPTPSPGRSPLD
CCCCCCCCCCCCCCC		42.3328985074
119UbiquitinationNGPTPSPGRSPLDSQ
CCCCCCCCCCCCCCC		47.2229967540
119 (in isoform 2)Phosphorylation-47.2211566027
121PhosphorylationPTPSPGRSPLDSQAS
CCCCCCCCCCCCCCC		35.4127080861
123 (in isoform 7)Phosphorylation-11.8911566027
125PhosphorylationPGRSPLDSQASPGLV
CCCCCCCCCCCCCEE		35.0227080861
128PhosphorylationSPLDSQASPGLVLHA
CCCCCCCCCCEEEEC		16.3227080861
131PhosphorylationDSQASPGLVLHAGAA
CCCCCCCEEEECCCC		4.1533259812
135PhosphorylationSPGLVLHAGAATSQR
CCCEEEECCCCCCHH		12.7333259812
139PhosphorylationVLHAGAATSQRRESF
EEECCCCCCHHHHHH		25.5127080861
140PhosphorylationLHAGAATSQRRESFL
EECCCCCCHHHHHHH		19.5727080861
145PhosphorylationATSQRRESFLYRSDS
CCCHHHHHHHCCCCC		20.8123927012
148PhosphorylationQRRESFLYRSDSDYD
HHHHHHHCCCCCCCC		13.1723403867
150PhosphorylationRESFLYRSDSDYDMS
HHHHHCCCCCCCCCC		28.1023663014
152PhosphorylationSFLYRSDSDYDMSPK
HHHCCCCCCCCCCCC		39.0423663014
154PhosphorylationLYRSDSDYDMSPKTM
HCCCCCCCCCCCCCC		19.9323663014
157PhosphorylationSDSDYDMSPKTMSRN
CCCCCCCCCCCCCCC		21.9823663014
165PhosphorylationPKTMSRNSSVTSEAH
CCCCCCCCCCCCHHH		25.6928450419
166PhosphorylationKTMSRNSSVTSEAHA
CCCCCCCCCCCHHHH		32.7228450419
168PhosphorylationMSRNSSVTSEAHAED
CCCCCCCCCHHHHHH		23.8528450419
169PhosphorylationSRNSSVTSEAHAEDL
CCCCCCCCHHHHHHC		30.5428464451
183PhosphorylationLIVTPFAQVLASLRS
CCCCHHHHHHHHHHH		31.0132142685
187PhosphorylationPFAQVLASLRSVRSN
HHHHHHHHHHHHHHC		21.8324719451
196PhosphorylationRSVRSNFSLLTNVPV
HHHHHCCEEECCCCC		27.0723312004
199PhosphorylationRSNFSLLTNVPVPSN
HHCCEEECCCCCCCC		39.1923312004
205PhosphorylationLTNVPVPSNKRSPLG
ECCCCCCCCCCCCCC		56.0423898821
209PhosphorylationPVPSNKRSPLGGPTP
CCCCCCCCCCCCCCC		26.5321712546
215PhosphorylationRSPLGGPTPVCKATL
CCCCCCCCCCCCCCC		31.4622617229
247PhosphorylationWCLEQLETMQTYRSV
HHHHHHHHHHHHHHH		24.1526074081
250PhosphorylationEQLETMQTYRSVSEM
HHHHHHHHHHHHHHH		15.3026074081
251PhosphorylationQLETMQTYRSVSEMA
HHHHHHHHHHHHHHH		5.5226074081
253PhosphorylationETMQTYRSVSEMASH
HHHHHHHHHHHHHHH		21.4126074081
253UbiquitinationETMQTYRSVSEMASH
HHHHHHHHHHHHHHH		21.4122817900
255PhosphorylationMQTYRSVSEMASHKF
HHHHHHHHHHHHHHH		23.9326074081
259PhosphorylationRSVSEMASHKFKRML
HHHHHHHHHHHHHHH		26.3726074081
271PhosphorylationRMLNRELTHLSEMSR
HHHHHHHHHHHHHHC		18.9323186163
277PhosphorylationLTHLSEMSRSGNQVS
HHHHHHHHCCCCHHH		21.1728555341
279PhosphorylationHLSEMSRSGNQVSEY
HHHHHHCCCCHHHHH		34.4927080861
297UbiquitinationTFLDKQNEVEIPSPT
HHCCCCCCEECCCCC		38.7529967540
301 (in isoform 5)Phosphorylation-22.2823684312
302PhosphorylationQNEVEIPSPTMKERE
CCCEECCCCCHHHHH		38.3729255136
303 (in isoform 5)Phosphorylation-31.0223684312
304PhosphorylationEVEIPSPTMKEREKQ
CEECCCCCHHHHHHH		45.2529255136
307 (in isoform 5)Phosphorylation-56.0723684312
318UbiquitinationQQAPRPRPSQPPPPP
HCCCCCCCCCCCCCC		39.7422817900
332UbiquitinationPVPHLQPMSQITGLK
CCCCCCCHHHHHCHH		2.7229967540
336UbiquitinationLQPMSQITGLKKLMH
CCCHHHHHCHHHHHC		28.9129967540
344PhosphorylationGLKKLMHSNSLNNSN
CHHHHHCCCCCCCCC		17.7228450419
346PhosphorylationKKLMHSNSLNNSNIP
HHHHCCCCCCCCCCC		35.1723911959
350PhosphorylationHSNSLNNSNIPRFGV
CCCCCCCCCCCCCCC		34.7528450419
358SumoylationNIPRFGVKTDQEELL
CCCCCCCCCCHHHHH		46.92-
358SumoylationNIPRFGVKTDQEELL
CCCCCCCCCCHHHHH		46.9220196770
358UbiquitinationNIPRFGVKTDQEELL
CCCCCCCCCCHHHHH		46.9229967540
496UbiquitinationNSELALMYNDESVLE
CCCEEEEECCCHHHH		21.9522817900
531UbiquitinationNLSKRQRQSLRKMVI
CCCHHHHHHHHHHHH		38.1822817900
535UbiquitinationRQRQSLRKMVIDMVL
HHHHHHHHHHHHHHH		42.6922817900
544PhosphorylationVIDMVLATDMSKHMT
HHHHHHHCCHHHHHH		28.2422817900
551PhosphorylationTDMSKHMTLLADLKT
CCHHHHHHHHHHHHH		20.52-
556UbiquitinationHMTLLADLKTMVETK
HHHHHHHHHHHHHCC		4.0722817900
557UbiquitinationMTLLADLKTMVETKK
HHHHHHHHHHHHCCC		34.8122817900
562PhosphorylationDLKTMVETKKVTSSG
HHHHHHHCCCCCCCC		25.4226074081
566PhosphorylationMVETKKVTSSGVLLL
HHHCCCCCCCCEEEE		26.5120068231
567PhosphorylationVETKKVTSSGVLLLD
HHCCCCCCCCEEEEC		28.2521815630
568PhosphorylationETKKVTSSGVLLLDN
HCCCCCCCCEEEECC		24.4520068231
576PhosphorylationGVLLLDNYSDRIQVL
CEEEECCHHHHHHHH		16.1826074081
577PhosphorylationVLLLDNYSDRIQVLR
EEEECCHHHHHHHHH		27.0226074081
628PhosphorylationRERGMEISPMCDKHT
HHHCCCCCCCCCCCC		8.0221815630
637PhosphorylationMCDKHTASVEKSQVG
CCCCCCCCCCHHHCC		31.7824719451
686PhosphorylationYYSAIRQSPSPPPEE
HHHHHHCCCCCCCHH		19.9328985074
688PhosphorylationSAIRQSPSPPPEEES
HHHHCCCCCCCHHHC		56.1115738310
807PhosphorylationEEFVVAVSHSSPSAL
CCEEEEEECCCHHHH		14.1228348404
809PhosphorylationFVVAVSHSSPSALAL
EEEEEECCCHHHHHH		36.1228348404
810PhosphorylationVVAVSHSSPSALALQ
EEEEECCCHHHHHHC		19.9028348404
812PhosphorylationAVSHSSPSALALQSP
EEECCCHHHHHHCCC		37.5528348404
818PhosphorylationPSALALQSPLLPAWR
HHHHHHCCCCCCHHH		20.5427251275
826PhosphorylationPLLPAWRTLSVSEHA
CCCCHHHEECHHHCC		16.8127080861
828PhosphorylationLPAWRTLSVSEHAPG
CCHHHEECHHHCCCC		24.0027080861
830PhosphorylationAWRTLSVSEHAPGLP
HHHEECHHHCCCCCC		21.9327080861
870PhosphorylationAGTFGEDTSALPAPG
CCCCCCCCCCCCCCC		16.17-
871PhosphorylationGTFGEDTSALPAPGG
CCCCCCCCCCCCCCC		39.88-
881PhosphorylationPAPGGGGSGGDPT--
CCCCCCCCCCCCC--		42.76-
886PhosphorylationGGSGGDPT-------
CCCCCCCC-------		56.85-
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
145SPhosphorylationKinasePRKACAP17612
GPS
152SPhosphorylationKinaseMAPKAPK2P49137
Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference
119SPhosphorylation

15738310
123SPhosphorylation

18095939
686SPhosphorylation

11566027
688SPhosphorylation

11566027
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of PDE4A_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
AKAP6_HUMANAKAP6physical
11296225
KAP2_HUMANPRKAR2Aphysical
11296225
SQSTM_HUMANSQSTM1physical
20600853
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
D00227 Aminophylline (USP/INN); Somophyllin (TN); Theophylline ethylenediamine (TN)
D00371 Theophylline (JP16); Elixophyllin (TN); Quibron-t (TN); Theo-24 (TN); Theodur G (TN); Theolair (TN);
D00528 Anhydrous caffeine (JP16); Caffeine (USP); Anhydrous caffeine (TN)
D00718 Flavoxate hydrochloride (JP16/USAN); Urispas (TN)
D01220 Trapidil (JP16/INN); Rocornal (TN)
D01385 Ibudilast (JP16/INN); Ketas (TN)
D01453 Caffeine hydrate (JP16); Caffeine monohydrate; Caffeine (TN)
D01630 Propentofylline (JAN/INN)
D01704 Cilomilast (JAN/USAN/INN); Ariflo (TN)
D01712 Theophylline sodium acetate (JAN)
D01771 Proxyphylline (JAN/INN); Monophyllin (TN)
D01783 Rolipram (JAN/USAN/INN)
D02017 Choline theophylline (JAN); Oxtriphylline (USP); Choline theophyllinate (INN); Theophyline - choline
D02218 Papaverine hydrochloride (JP16/USP); Pavabid (TN)
D02985 Arofylline (USAN/INN)
D03898 Doxofylline (USAN/INN); Maxivent (TN)
D04185 Filaminast (USAN/INN)
D05429 Aminophylline hydrate (JP16)
D05474 Piclamilast (USAN/INN)
D05744 Roflumilast (JAN/USAN/INN); Daliresp (TN)
D06103 Theophylline (USP); Theophylline monohydrate; Accurbron (TN)
D06104 Theophylline sodium glycinate (USP); Asbron (TN)
D06132 Tibenelast sodium (USAN)
D06575 Catramilast (USAN/INN)
D07089 Moxaverine (INN)
D07425 Papaverine (BAN); Mesotina (TN)
D07439 Papaverine sulfate; Papaverine SAD (TN)
D07603 Caffeine citrate (USP); Cafcit (TN)
D07961 Flavoxate (INN); Bladuril (TN)
D08238 Moxaverine hydrochloride; Certonal (TN)
D08860 Apremilast (USAN)
D09020 Tofimilast (INN/USAN)
DrugBank
DB00201Caffeine
DB00975Dipyridamole
DB06751Drotaverine
DB00651Dyphylline
DB00824Enprofylline
DB05266Ibudilast
DB01088Iloprost
DB00920Ketotifen
DB01303Oxtriphylline
DB00806Pentoxifylline
DB01656Roflumilast
DB00277Theophylline
DB08811Tofisopam
Regulatory Network of PDE4A_HUMAN

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Related Literatures of Post-Translational Modification
Sumoylation
ReferencePubMed
"Selective SUMO modification of cAMP-specific phosphodiesterase-4D5(PDE4D5) regulates the functional consequences of phosphorylation byPKA and ERK.";
Li X., Vadrevu S., Dunlop A., Day J., Advant N., Troeger J.,Klussmann E., Jaffrey E., Hay R.T., Adams D.R., Houslay M.D.,Baillie G.S.;
Biochem. J. 428:55-65(2010).
Cited for: SUMOYLATION AT LYS-358 BY PIAS4.

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