TRPM4_HUMAN - dbPTM
TRPM4_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID TRPM4_HUMAN
UniProt AC Q8TD43
Protein Name Transient receptor potential cation channel subfamily M member 4
Gene Name TRPM4
Organism Homo sapiens (Human).
Sequence Length 1214
Subcellular Localization Isoform 1: Cell membrane
Multi-pass membrane protein . Endoplasmic reticulum . Golgi apparatus .
Isoform 2: Cell membrane . Endoplasmic reticulum. Golgi apparatus.
Protein Description Calcium-activated non selective (CAN) cation channel that mediates membrane depolarization. [PubMed: 12015988]
Protein Sequence MVVPEKEQSWIPKIFKKKTCTTFIVDSTDPGGTLCQCGRPRTAHPAVAMEDAFGAAVVTVWDSDAHTTEKPTDAYGELDFTGAGRKHSNFLRLSDRTDPAAVYSLVTRTWGFRAPNLVVSVLGGSGGPVLQTWLQDLLRRGLVRAAQSTGAWIVTGGLHTGIGRHVGVAVRDHQMASTGGTKVVAMGVAPWGVVRNRDTLINPKGSFPARYRWRGDPEDGVQFPLDYNYSAFFLVDDGTHGCLGGENRFRLRLESYISQQKTGVGGTGIDIPVLLLLIDGDEKMLTRIENATQAQLPCLLVAGSGGAADCLAETLEDTLAPGSGGARQGEARDRIRRFFPKGDLEVLQAQVERIMTRKELLTVYSSEDGSEEFETIVLKALVKACGSSEASAYLDELRLAVAWNRVDIAQSELFRGDIQWRSFHLEASLMDALLNDRPEFVRLLISHGLSLGHFLTPMRLAQLYSAAPSNSLIRNLLDQASHSAGTKAPALKGGAAELRPPDVGHVLRMLLGKMCAPRYPSGGAWDPHPGQGFGESMYLLSDKATSPLSLDAGLGQAPWSDLLLWALLLNRAQMAMYFWEMGSNAVSSALGACLLLRVMARLEPDAEEAARRKDLAFKFEGMGVDLFGECYRSSEVRAARLLLRRCPLWGDATCLQLAMQADARAFFAQDGVQSLLTQKWWGDMASTTPIWALVLAFFCPPLIYTRLITFRKSEEEPTREELEFDMDSVINGEGPVGTADPAEKTPLGVPRQSGRPGCCGGRCGGRRCLRRWFHFWGAPVTIFMGNVVSYLLFLLLFSRVLLVDFQPAPPGSLELLLYFWAFTLLCEELRQGLSGGGGSLASGGPGPGHASLSQRLRLYLADSWNQCDLVALTCFLLGVGCRLTPGLYHLGRTVLCIDFMVFTVRLLHIFTVNKQLGPKIVIVSKMMKDVFFFLFFLGVWLVAYGVATEGLLRPRDSDFPSILRRVFYRPYLQIFGQIPQEDMDVALMEHSNCSSEPGFWAHPPGAQAGTCVSQYANWLVVLLLVIFLLVANILLVNLLIAMFSYTFGKVQGNSDLYWKAQRYRLIREFHSRPALAPPFIVISHLRLLLRQLCRRPRSPQPSSPALEHFRVYLSKEAERKLLTWESVHKENFLLARARDKRESDSERLKRTSQKVDLALKQLGHIREYEQRLKVLEREVQQCSRVLGWVAEALSRSALLPPGGPPPPDLPGSKD
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
94PhosphorylationHSNFLRLSDRTDPAA
CCCEEECCCCCCHHH		20.7223401153
97PhosphorylationFLRLSDRTDPAAVYS
EEECCCCCCHHHHHH		51.8623898821
103PhosphorylationRTDPAAVYSLVTRTW
CCCHHHHHHHHHCCC		7.4923898821
104PhosphorylationTDPAAVYSLVTRTWG
CCHHHHHHHHHCCCC		15.1219413330
107PhosphorylationAAVYSLVTRTWGFRA
HHHHHHHHCCCCCCC		27.8928348404
109PhosphorylationVYSLVTRTWGFRAPN
HHHHHHCCCCCCCCC		22.1528348404
177PhosphorylationVRDHQMASTGGTKVV
ECCCEECCCCCCEEE		23.4225072903
178PhosphorylationRDHQMASTGGTKVVA
CCCEECCCCCCEEEE		30.0525072903
181PhosphorylationQMASTGGTKVVAMGV
EECCCCCCEEEEEEE		23.2425072903
255PhosphorylationRFRLRLESYISQQKT
HHHHHHHHHHHCCCC		32.1523312004
256PhosphorylationFRLRLESYISQQKTG
HHHHHHHHHHCCCCC		8.6723312004
313 (in isoform 2)Ubiquitination-40.7621890473
318 (in isoform 2)Ubiquitination-18.5521890473
362PhosphorylationMTRKELLTVYSSEDG
HHHHHHEEEEECCCC		29.9829759185
364PhosphorylationRKELLTVYSSEDGSE
HHHHEEEEECCCCCH		10.9729978859
365PhosphorylationKELLTVYSSEDGSEE
HHHEEEEECCCCCHH		23.9429759185
366PhosphorylationELLTVYSSEDGSEEF
HHEEEEECCCCCHHH		23.2429759185
370PhosphorylationVYSSEDGSEEFETIV
EEECCCCCHHHHHHH		46.4029978859
375PhosphorylationDGSEEFETIVLKALV
CCCHHHHHHHHHHHH		23.0029978859
411PhosphorylationNRVDIAQSELFRGDI
HCCHHHHHHHHCCCC		27.52-
446PhosphorylationEFVRLLISHGLSLGH
HHHHHHHHCCCCHHH		16.0926074081
450PhosphorylationLLISHGLSLGHFLTP
HHHHCCCCHHHCCCH		36.5826074081
456PhosphorylationLSLGHFLTPMRLAQL
CCHHHCCCHHHHHHH		17.6926074081
481PhosphorylationRNLLDQASHSAGTKA
HHHHHHHHHCCCCCC		16.6123312004
483PhosphorylationLLDQASHSAGTKAPA
HHHHHHHCCCCCCHH		26.3723312004
486PhosphorylationQASHSAGTKAPALKG
HHHHCCCCCCHHHCC		24.6123312004
487 (in isoform 1)Ubiquitination-52.0021890473
487UbiquitinationASHSAGTKAPALKGG
HHHCCCCCCHHHCCC		52.0021906983
487 (in isoform 3)Ubiquitination-52.0021890473
492 (in isoform 1)Ubiquitination-58.3621890473
492UbiquitinationGTKAPALKGGAAELR
CCCCHHHCCCCCCCC		58.3621906983
492 (in isoform 3)Ubiquitination-58.3621890473
536PhosphorylationPGQGFGESMYLLSDK
CCCCCCCCEEEECCC		17.0724719451
538PhosphorylationQGFGESMYLLSDKAT
CCCCCCEEEECCCCC		17.4827642862
541PhosphorylationGESMYLLSDKATSPL
CCCEEEECCCCCCCC		34.1723312004
577PhosphorylationNRAQMAMYFWEMGSN
CHHHHHHHHHHHCHH		8.9418083107
728PhosphorylationELEFDMDSVINGEGP
HEEECHHHHHCCCCC		20.4726657352
839PhosphorylationGLSGGGGSLASGGPG
CCCCCCCCCCCCCCC		24.84-
885 (in isoform 2)Ubiquitination-35.0721890473
914 (in isoform 3)Ubiquitination-42.4321890473
955 (in isoform 2)Ubiquitination-50.0221890473
984 (in isoform 3)Ubiquitination-34.5521890473
986 (in isoform 2)Ubiquitination-9.2721890473
992N-linked_GlycosylationVALMEHSNCSSEPGF
HHHHHCCCCCCCCCC		31.4329217581
1015 (in isoform 3)Ubiquitination-8.3921890473
1059 (in isoform 1)Ubiquitination-22.5321890473
1059UbiquitinationGNSDLYWKAQRYRLI
CCCHHHHHHHHHHHH		22.5321890473
1098PhosphorylationQLCRRPRSPQPSSPA
HHHCCCCCCCCCCHH		30.4827251275
1102PhosphorylationRPRSPQPSSPALEHF
CCCCCCCCCHHHHHH		43.6426657352
1103PhosphorylationPRSPQPSSPALEHFR
CCCCCCCCHHHHHHH		22.3725849741
1112PhosphorylationALEHFRVYLSKEAER
HHHHHHHCCCHHHHH		10.87-
1115UbiquitinationHFRVYLSKEAERKLL
HHHHCCCHHHHHHHC		59.35-
1129 (in isoform 1)Ubiquitination-52.8021890473
1129UbiquitinationLTWESVHKENFLLAR
CCHHHHHHHCHHHHH		52.8021890473
1143PhosphorylationRARDKRESDSERLKR
HHHCCCCCHHHHHHH		50.9329449344
1145PhosphorylationRDKRESDSERLKRTS
HCCCCCHHHHHHHHH		33.6215590641
1151PhosphorylationDSERLKRTSQKVDLA
HHHHHHHHHHHHHHH		33.6423312004
1152PhosphorylationSERLKRTSQKVDLAL
HHHHHHHHHHHHHHH		31.8516424899
1160 (in isoform 1)Ubiquitination-37.5621890473
1160UbiquitinationQKVDLALKQLGHIRE
HHHHHHHHHHHHHHH		37.5621890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources
839SPhosphorylationKinaseCSNK1EP49674
GPS
1145SPhosphorylationKinasePRKCAP17252
GPS
1145SPhosphorylationKinasePKC-Uniprot
1152SPhosphorylationKinasePRKCAP17252
GPS
1152SPhosphorylationKinasePKC-Uniprot
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of TRPM4_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of TRPM4_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of TRPM4_HUMAN !!
Drug and Disease Associations
Kegg Disease
H01263 Progressive cardiac conduction defect (PCCD); Progressive familial heart block (PFHB); Lenegre-Lev d
OMIM Disease
604559Progressive familial heart block 1B (PFHB1B)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of TRPM4_HUMAN

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Related Literatures of Post-Translational Modification

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