LYPL1_HUMAN - dbPTM
LYPL1_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID LYPL1_HUMAN
UniProt AC Q5VWZ2
Protein Name Lysophospholipase-like protein 1
Gene Name LYPLAL1
Organism Homo sapiens (Human).
Sequence Length 237
Subcellular Localization Isoform 1: Cytoplasm, cytosol .
Isoform 2: Cytoplasm, cytosol .
Protein Description Has depalmitoylating activity toward KCNMA1. Does not exhibit phospholipase nor triacylglycerol lipase activity, able to hydrolyze only short chain substrates due to its shallow active site..
Protein Sequence MAAASGSVLQRCIVSPAGRHSASLIFLHGSGDSGQGLRMWIKQVLNQDLTFQHIKIIYPTAPPRSYTPMKGGISNVWFDRFKITNDCPEHLESIDVMCQVLTDLIDEEVKSGIKKNRILIGGFSMGGCMAIHLAYRNHQDVAGVFALSSFLNKASAVYQALQKSNGVLPELFQCHGTADELVLHSWAEETNSMLKSLGVTTKFHSFPNVYHELSKTELDILKLWILTKLPGEMEKQK
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
2Acetylation------MAAASGSVL
------CCCCCCCHH		16.2525944712
7Phosphorylation-MAAASGSVLQRCIV
-CCCCCCCHHHHHHC		19.7028857561
15PhosphorylationVLQRCIVSPAGRHSA
HHHHHHCCCCCCCEE		6.7921406692
17UbiquitinationQRCIVSPAGRHSASL
HHHHCCCCCCCEEEE		21.8321890473
21PhosphorylationVSPAGRHSASLIFLH
CCCCCCCEEEEEEEE		20.4227080861
23PhosphorylationPAGRHSASLIFLHGS
CCCCCEEEEEEEECC		25.6427080861
30PhosphorylationSLIFLHGSGDSGQGL
EEEEEECCCCCCHHH		28.7821406692
32UbiquitinationIFLHGSGDSGQGLRM
EEEECCCCCCHHHHH		51.8221890473
33PhosphorylationFLHGSGDSGQGLRMW
EEECCCCCCHHHHHH		36.2221406692
41UbiquitinationGQGLRMWIKQVLNQD
CHHHHHHHHHHHCCC		1.3121890473
55 (in isoform 1)Ubiquitination-22.4121890473
55UbiquitinationDLTFQHIKIIYPTAP
CCCEEEEEEEECCCC		22.4121890473
55 (in isoform 2)Ubiquitination-22.4121890473
55UbiquitinationDLTFQHIKIIYPTAP
CCCEEEEEEEECCCC		22.4121890473
66PhosphorylationPTAPPRSYTPMKGGI
CCCCCCCCCCCCCCC		19.01-
70UbiquitinationPRSYTPMKGGISNVW
CCCCCCCCCCCCEEE		56.0121890473
70UbiquitinationPRSYTPMKGGISNVW
CCCCCCCCCCCCEEE		56.0121890473
70 (in isoform 1)Ubiquitination-56.0121890473
74PhosphorylationTPMKGGISNVWFDRF
CCCCCCCCEEEECEE		28.7128857561
79UbiquitinationGISNVWFDRFKITND
CCCEEEECEEEEECC		39.1221890473
124PhosphorylationRILIGGFSMGGCMAI
CEEEECCCHHHHHHH		21.57-
151UbiquitinationVFALSSFLNKASAVY
HHHHHHHHHHHHHHH		7.5029967540
164UbiquitinationVYQALQKSNGVLPEL
HHHHHHHCCCCCCHH		26.3429967540
174UbiquitinationVLPELFQCHGTADEL
CCCHHHCCCCCHHHH		2.2121890473
177UbiquitinationELFQCHGTADELVLH
HHHCCCCCHHHHHHH		13.7921890473
186UbiquitinationDELVLHSWAEETNSM
HHHHHHHHHHHHHHH		9.2829967540
190UbiquitinationLHSWAEETNSMLKSL
HHHHHHHHHHHHHHC		24.8921890473
199UbiquitinationSMLKSLGVTTKFHSF
HHHHHCCCCCCCCCC		8.1321890473
202UbiquitinationKSLGVTTKFHSFPNV
HHCCCCCCCCCCCCH		31.5429967540
202AcetylationKSLGVTTKFHSFPNV
HHCCCCCCCCCCCCH		31.5425953088
202MalonylationKSLGVTTKFHSFPNV
HHCCCCCCCCCCCCH		31.5430639696
212 (in isoform 2)Ubiquitination-36.7321890473
212UbiquitinationSFPNVYHELSKTELD
CCCCHHHHCCHHHHH		36.7321890473
214PhosphorylationPNVYHELSKTELDIL
CCHHHHCCHHHHHHH		34.2529083192
221UbiquitinationSKTELDILKLWILTK
CHHHHHHHHHHHHHC		3.5821890473
228UbiquitinationLKLWILTKLPGEMEK
HHHHHHHCCCCHHHH		49.6021890473
228 (in isoform 1)Ubiquitination-49.6021890473
228UbiquitinationLKLWILTKLPGEMEK
HHHHHHHCCCCHHHH		49.6021890473
235UbiquitinationKLPGEMEKQK-----
CCCCHHHHCC-----		63.18-
237UbiquitinationPGEMEKQK-------
CCHHHHCC-------		73.6721890473
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of LYPL1_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of LYPL1_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of LYPL1_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions

Oops, there are no PPI records of LYPL1_HUMAN !!
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of LYPL1_HUMAN

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Related Literatures of Post-Translational Modification
Acetylation
ReferencePubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach.";
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.;
Anal. Chem. 81:4493-4501(2009).
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, AND MASS SPECTROMETRY.

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