DRG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: DRG2_HUMAN
• UniProt AC: P55039
• Protein Name: Developmentally-regulated GTP-binding protein 2
• Gene Name: DRG2
• Organism: Homo sapiens (Human).
• Sequence Length: 364
• Subcellular Localization: Cytoplasm.
• Protein Description: May play a role in cell proliferation, differentiation and death..
• Protein Sequence: MGILEKISEIEKEIARTQKNKATEYHLGLLKAKLAKYRAQLLEPSKSASSKGEGFDVMKSGDARVALIGFPSVGKSTFLSLMTSTASEAASYEFTTLTCIPGVIEYKGANIQLLDLPGIIEGAAQGKGRGRQVIAVARTADVIIMMLDATKGEVQRSLLEKELESVGIRLNKHKPNIYFKPKKGGGISFNSTVTLTQCSEKLVQLILHEYKIFNAEVLFREDCSPDEFIDVIVGNRVYMPCLYVYNKIDQISMEEVDRLARKPNSVVISCGMKLNLDYLLEMLWEYLALTCIYTKKRGQRPDFTDAIILRKGASVEHVCHRIHRSLASQFKYALVWGTSTKYSPQRVGLTHTMEHEDVIQIVKK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
6	Ubiquitination	--MGILEKISEIEKE --CCHHHHHHHHHHH	48.35	-
12	Ubiquitination	EKISEIEKEIARTQK HHHHHHHHHHHHHHH	61.14	-
21	Hydroxylation	IARTQKNKATEYHLG HHHHHHCHHHHHHHH	64.82	29915238
25	Phosphorylation	QKNKATEYHLGLLKA HHCHHHHHHHHHHHH	9.67	27642862
31	Ubiquitination	EYHLGLLKAKLAKYR HHHHHHHHHHHHHHH	48.82	-
37	Phosphorylation	LKAKLAKYRAQLLEP HHHHHHHHHHHHCCC	12.94	28152594
45	Phosphorylation	RAQLLEPSKSASSKG HHHHCCCCCCCCCCC	29.84	20068231
46	Ubiquitination	AQLLEPSKSASSKGE HHHCCCCCCCCCCCC	61.84	21890473
49	Phosphorylation	LEPSKSASSKGEGFD CCCCCCCCCCCCCCE	39.41	28555341
51	Ubiquitination	PSKSASSKGEGFDVM CCCCCCCCCCCCEEE	59.49	21906983
58	Sulfoxidation	KGEGFDVMKSGDARV CCCCCEEECCCCEEE	2.84	30846556
59	Ubiquitination	GEGFDVMKSGDARVA CCCCEEECCCCEEEE	51.65	21906983
72	Phosphorylation	VALIGFPSVGKSTFL EEEEECCCCCHHHHH	41.04	-
106	Phosphorylation	CIPGVIEYKGANIQL ECCCEEEECCCEEEE	12.00	-
127	Ubiquitination	IEGAAQGKGRGRQVI HHHHHCCCCCCCHHE	33.10	21906983
139	Phosphorylation	QVIAVARTADVIIMM HHEEEEECCCEEEEE	19.92	-
151	Ubiquitination	IMMLDATKGEVQRSL EEEECCCCHHHHHHH	55.59	-
157	Phosphorylation	TKGEVQRSLLEKELE CCHHHHHHHHHHHHH	21.88	24719451
161	Ubiquitination	VQRSLLEKELESVGI HHHHHHHHHHHHHCC	68.51	21890473
161	Ubiquitination	VQRSLLEKELESVGI HHHHHHHHHHHHHCC	68.51	21890473
178	Phosphorylation	NKHKPNIYFKPKKGG CCCCCCEEECCCCCC	16.52	-
253	Sulfoxidation	NKIDQISMEEVDRLA ECCCCCCHHHHHHHH	5.63	21406390
269	Phosphorylation	KPNSVVISCGMKLNL CCCEEEEECCCCCCH	7.94	-
290	Phosphorylation	LWEYLALTCIYTKKR HHHHHHHHHHHHCCC	7.40	-
294	Phosphorylation	LALTCIYTKKRGQRP HHHHHHHHCCCCCCC	15.35	-
325	Phosphorylation	VCHRIHRSLASQFKY HHHHHHHHHHHHCCE	17.71	28555341
332	Phosphorylation	SLASQFKYALVWGTS HHHHHCCEEEEECCC	13.37	21406692
338	Phosphorylation	KYALVWGTSTKYSPQ CEEEEECCCCCCCCC	19.94	21406692
339	Phosphorylation	YALVWGTSTKYSPQR EEEEECCCCCCCCCC	20.97	21406692
340	Phosphorylation	ALVWGTSTKYSPQRV EEEECCCCCCCCCCC	33.56	21406692
341	Ubiquitination	LVWGTSTKYSPQRVG EEECCCCCCCCCCCC	43.42	21890473
341	Ubiquitination	LVWGTSTKYSPQRVG EEECCCCCCCCCCCC	43.42	21890473

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
72	S	Phosphorylation	Kinase	CHEK1	O14757	GPS

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
21	K	Hydroxylation	Hydroxylated (with S stereochemistry) at C-3 of Lys-21 by JMJD7; this modification hinders trypsin-catalyzed proteolysis in vitro.	29915238

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of DRG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RWDD1_HUMAN	RWDD1	physical	16189514
RWDD1_HUMAN	RWDD1	physical	22939629
RSBNL_HUMAN	RSBN1L	physical	22939629
PUR8_HUMAN	ADSL	physical	22863883
API5_HUMAN	API5	physical	22863883
EHD1_HUMAN	EHD1	physical	22863883
5NTC_HUMAN	NT5C2	physical	22863883
UB2R2_HUMAN	UBE2R2	physical	22863883
RWDD1_HUMAN	RWDD1	physical	25416956
HSP7C_HUMAN	HSPA8	physical	26186194
RWDD1_HUMAN	RWDD1	physical	26186194
DDX55_HUMAN	DDX55	physical	26344197
RWDD1_HUMAN	RWDD1	physical	26344197
CUL1_HUMAN	CUL1	physical	22450327
SKP1_HUMAN	SKP1	physical	22450327
RWDD1_HUMAN	RWDD1	physical	28514442
HSP7C_HUMAN	HSPA8	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.