dbPTM

PACS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	PACS1_HUMAN
UniProt AC	Q6VY07
Protein Name	Phosphofurin acidic cluster sorting protein 1
Gene Name	PACS1
Organism	Homo sapiens (Human).
Sequence Length	963
Subcellular Localization	Golgi apparatus, trans-Golgi network . Localizes in the perinuclear region, probably the TGN.
Protein Description	Coat protein that is involved in the localization of trans-Golgi network (TGN) membrane proteins that contain acidic cluster sorting motifs. Controls the endosome-to-Golgi trafficking of furin and mannose-6-phosphate receptor by connecting the acidic-cluster-containing cytoplasmic domain of these molecules with the adapter-protein complex-1 (AP-1) of endosomal clathrin-coated membrane pits. Involved in HIV-1 nef-mediated removal of MHC-I from the cell surface to the TGN..
Protein Sequence	MAERGGAGGGPGGAGGGSGQRGSGVAQSPQQPPPQQQQQQPPQQPTPPKLAQATSSSSSTSAAAASSSSSSTSTSMAVAVASGSAPPGGPGPGRTPAPVQMNLYATWEVDRSSSSCVPRLFSLTLKKLVMLKEMDKDLNSVVIAVKLQGSKRILRSNEIVLPASGLVETELQLTFSLQYPHFLKRDANKLQIMLQRRKRYKNRTILGYKTLAVGLINMAEVMQHPNEGALVLGLHSNVKDVSVPVAEIKIYSLSSQPIDHEGIKSKLSDRSPDIDNYSEEEEESFSSEQEGSDDPLHGQDLFYEDEDLRKVKKTRRKLTSTSAITRQPNIKQKFVALLKRFKVSDEVGFGLEHVSREQIREVEEDLDELYDSLEMYNPSDSGPEMEETESILSTPKPKLKPFFEGMSQSSSQTEIGSLNSKGSLGKDTTSPMELAALEKIKSTWIKNQDDSLTETDTLEITDQDMFGDASTSLVVPEKVKTPMKSSKTDLQGSASPSKVEGVHTPRQKRSTPLKERQLSKPLSERTNSSDSERSPDLGHSTQIPRKVVYDQLNQILVSDAALPENVILVNTTDWQGQYVAELLQDQRKPVVCTCSTVEVQAVLSALLTRIQRYCNCNSSMPRPVKVAAVGGQSYLSSILRFFVKSLANKTSDWLGYMRFLIIPLGSHPVAKYLGSVDSKYSSSFLDSGWRDLFSRSEPPVSEQLDVAGRVMQYVNGAATTHQLPVAEAMLTCRHKFPDEDSYQKFIPFIGVVKVGLVEDSPSTAGDGDDSPVVSLTVPSTSPPSSSGLSRDATATPPSSPSMSSALAIVGSPNSPYGDVIGLQVDYWLGHPGERRREGDKRDASSKNTLKSVFRSVQVSRLPHSGEAQLSGTMAMTVVTKEKNKKVPTIFLSKKPREKEVDSKSQVIEGISRLICSAKQQQTMLRVSIDGVEWSDIKFFQLAAQWPTHVKHFPVGLFSGSKAT

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
2	Acetylation	------MAERGGAGG ------CCCCCCCCC	18.39	19413330
4	Methylation	----MAERGGAGGGP ----CCCCCCCCCCC	39.03	115387237
18	Phosphorylation	PGGAGGGSGQRGSGV CCCCCCCCCCCCCCC	34.72	25159151
23	Phosphorylation	GGSGQRGSGVAQSPQ CCCCCCCCCCCCCCC	32.08	23663014
28	Phosphorylation	RGSGVAQSPQQPPPQ CCCCCCCCCCCCCCH	18.22	25159151
46	Phosphorylation	QQPPQQPTPPKLAQA CCCCCCCCCCHHHHH	48.13	29255136
54	Phosphorylation	PPKLAQATSSSSSTS CCHHHHHCCCCCCHH	19.63	30576142
69	Phosphorylation	AAAASSSSSSTSTSM HHHHHCCCCCCCCEE	30.20	30576142
104	Phosphorylation	APVQMNLYATWEVDR CCEEEEEEEEEEECC	9.29	29978859
104 (in isoform 2)	Phosphorylation	-	9.29	27642862
106	Phosphorylation	VQMNLYATWEVDRSS EEEEEEEEEEECCCC	14.49	29978859
112	Phosphorylation	ATWEVDRSSSSCVPR EEEEECCCCCCHHHH	30.06	-
113	Phosphorylation	TWEVDRSSSSCVPRL EEEECCCCCCHHHHH	27.45	-
114	Phosphorylation	WEVDRSSSSCVPRLF EEECCCCCCHHHHHH	29.07	-
115	Phosphorylation	EVDRSSSSCVPRLFS EECCCCCCHHHHHHH	22.53	-
122	Phosphorylation	SCVPRLFSLTLKKLV CHHHHHHHHHHHHHH	25.65	24719451
124	Phosphorylation	VPRLFSLTLKKLVML HHHHHHHHHHHHHHH	35.02	20068231
132	Acetylation	LKKLVMLKEMDKDLN HHHHHHHHHHCCCCC	32.66	7973175
151	Acetylation	AVKLQGSKRILRSNE EEEECCCCEEEECCC	50.73	7973187
204	Phosphorylation	RKRYKNRTILGYKTL HHHHCCCEECCHHHH	29.92	20873877
249	Ubiquitination	SVPVAEIKIYSLSSQ ECEEEEEEEEECCCC	27.39	-
251	Phosphorylation	PVAEIKIYSLSSQPI EEEEEEEEECCCCCC	9.88	25159151
251 (in isoform 2)	Phosphorylation	-	9.88	27642862
252	Phosphorylation	VAEIKIYSLSSQPID EEEEEEEECCCCCCC	25.83	28152594
254	Phosphorylation	EIKIYSLSSQPIDHE EEEEEECCCCCCCCH	22.46	28152594
255	Phosphorylation	IKIYSLSSQPIDHEG EEEEECCCCCCCCHH	45.31	-
264	Ubiquitination	PIDHEGIKSKLSDRS CCCCHHHHHHHCCCC	53.01	-
266	Ubiquitination	DHEGIKSKLSDRSPD CCHHHHHHHCCCCCC	47.19	-
278	Dephosphorylation	SPDIDNYSEEEEESF CCCCCCCCHHHHHHH	44.80	14633983
278	Phosphorylation	SPDIDNYSEEEEESF CCCCCCCCHHHHHHH	44.80	14633983
292	Phosphorylation	FSSEQEGSDDPLHGQ HCCCCCCCCCCCCCC	37.78	24275569
303	Phosphorylation	LHGQDLFYEDEDLRK CCCCCCCCCCHHHHH	29.75	-
317	Ubiquitination	KVKKTRRKLTSTSAI HHHHHHHHHHCCCHH	53.47	-
319	Phosphorylation	KKTRRKLTSTSAITR HHHHHHHHCCCHHHC	32.75	28450419
320	Phosphorylation	KTRRKLTSTSAITRQ HHHHHHHCCCHHHCC	30.70	25159151
321	Phosphorylation	TRRKLTSTSAITRQP HHHHHHCCCHHHCCC	19.55	28450419
322	Phosphorylation	RRKLTSTSAITRQPN HHHHHCCCHHHCCCC	19.90	19276368
325	Phosphorylation	LTSTSAITRQPNIKQ HHCCCHHHCCCCHHH	23.98	28450419
333	Ubiquitination	RQPNIKQKFVALLKR CCCCHHHHHHHHHHH	36.48	-
339	2-Hydroxyisobutyrylation	QKFVALLKRFKVSDE HHHHHHHHHCCCCCC	57.55	-
339	Ubiquitination	QKFVALLKRFKVSDE HHHHHHHHHCCCCCC	57.55	21890473
339 (in isoform 1)	Ubiquitination	-	57.55	21890473
339 (in isoform 2)	Ubiquitination	-	57.55	21890473
344	Phosphorylation	LLKRFKVSDEVGFGL HHHHCCCCCCCCCCC	28.75	28555341
355	Phosphorylation	GFGLEHVSREQIREV CCCCCCCCHHHHHHH	31.82	25849741
370	Phosphorylation	EEDLDELYDSLEMYN HHHHHHHHHHHHHHC	11.05	28060719
370 (in isoform 2)	Phosphorylation	-	11.05	27642862
372	Phosphorylation	DLDELYDSLEMYNPS HHHHHHHHHHHHCCC	16.81	28060719
376	Phosphorylation	LYDSLEMYNPSDSGP HHHHHHHHCCCCCCC	17.97	28060719
379	Phosphorylation	SLEMYNPSDSGPEME HHHHHCCCCCCCCHH	40.55	18669648
379 (in isoform 2)	Phosphorylation	-	40.55	27642862
381	Phosphorylation	EMYNPSDSGPEMEET HHHCCCCCCCCHHHH	61.66	23898821
381 (in isoform 2)	Phosphorylation	-	61.66	27642862
388	Phosphorylation	SGPEMEETESILSTP CCCCHHHHHHHHCCC	23.02	28060719
388 (in isoform 2)	Phosphorylation	-	23.02	27642862
390	Phosphorylation	PEMEETESILSTPKP CCHHHHHHHHCCCCC	35.93	28060719
393	Phosphorylation	EETESILSTPKPKLK HHHHHHHCCCCCCCC	40.78	25841592
393 (in isoform 2)	Phosphorylation	-	40.78	27642862
394	Phosphorylation	ETESILSTPKPKLKP HHHHHHCCCCCCCCH	31.70	28060719
394 (in isoform 2)	Phosphorylation	-	31.70	27642862
407	Phosphorylation	KPFFEGMSQSSSQTE CHHHCCCCCCCCCCC	37.45	17525332
409	Phosphorylation	FFEGMSQSSSQTEIG HHCCCCCCCCCCCCC	25.34	21712546
410	Phosphorylation	FEGMSQSSSQTEIGS HCCCCCCCCCCCCCC	20.87	23401153
411	Phosphorylation	EGMSQSSSQTEIGSL CCCCCCCCCCCCCCC	46.50	23401153
413	Phosphorylation	MSQSSSQTEIGSLNS CCCCCCCCCCCCCCC	31.36	30108239
417	Phosphorylation	SSQTEIGSLNSKGSL CCCCCCCCCCCCCCC	30.00	30108239
420	Phosphorylation	TEIGSLNSKGSLGKD CCCCCCCCCCCCCCC	43.62	22199227
423	Phosphorylation	GSLNSKGSLGKDTTS CCCCCCCCCCCCCCC	37.37	30108239
426	Acetylation	NSKGSLGKDTTSPME CCCCCCCCCCCCHHH	58.14	19827559
428	Phosphorylation	KGSLGKDTTSPMELA CCCCCCCCCCHHHHH	32.43	30266825
429	Phosphorylation	GSLGKDTTSPMELAA CCCCCCCCCHHHHHH	40.75	30266825
430	Phosphorylation	SLGKDTTSPMELAAL CCCCCCCCHHHHHHH	25.09	25159151
439	Ubiquitination	MELAALEKIKSTWIK HHHHHHHHHHHHCCC	57.17	-
443	O-linked_Glycosylation	ALEKIKSTWIKNQDD HHHHHHHHCCCCCCC	26.63	29351928
451	Phosphorylation	WIKNQDDSLTETDTL CCCCCCCCCCCCCEE	45.54	27251275
453	Phosphorylation	KNQDDSLTETDTLEI CCCCCCCCCCCEEEE	40.57	27690223
455	Phosphorylation	QDDSLTETDTLEITD CCCCCCCCCEEEECC	29.11	27251275
457	Phosphorylation	DSLTETDTLEITDQD CCCCCCCEEEECCHH	33.44	27251275
481	Phosphorylation	VVPEKVKTPMKSSKT ECCCCCCCCCCCCCC	31.44	24719451
485	Phosphorylation	KVKTPMKSSKTDLQG CCCCCCCCCCCCCCC	30.71	28857561
486	Phosphorylation	VKTPMKSSKTDLQGS CCCCCCCCCCCCCCC	33.77	26074081
488	Phosphorylation	TPMKSSKTDLQGSAS CCCCCCCCCCCCCCC	43.84	23927012
493	Phosphorylation	SKTDLQGSASPSKVE CCCCCCCCCCHHHCC	16.77	25159151
495	Phosphorylation	TDLQGSASPSKVEGV CCCCCCCCHHHCCCC	31.25	23927012
497	Phosphorylation	LQGSASPSKVEGVHT CCCCCCHHHCCCCCC	47.00	23401153
504	Phosphorylation	SKVEGVHTPRQKRST HHCCCCCCCCCCCCC	20.12	23401153
510	Phosphorylation	HTPRQKRSTPLKERQ CCCCCCCCCCCCHHH	41.22	23312004
511	Phosphorylation	TPRQKRSTPLKERQL CCCCCCCCCCCHHHC	36.35	23312004
519	Phosphorylation	PLKERQLSKPLSERT CCCHHHCCCCHHHCC	24.72	23898821
520	Acetylation	LKERQLSKPLSERTN CCHHHCCCCHHHCCC	59.58	25953088
523	Phosphorylation	RQLSKPLSERTNSSD HHCCCCHHHCCCCCC	33.29	30576142
526	Phosphorylation	SKPLSERTNSSDSER CCCHHHCCCCCCCCC	35.09	23927012
526 (in isoform 2)	Phosphorylation	-	35.09	21406692
528	Phosphorylation	PLSERTNSSDSERSP CHHHCCCCCCCCCCC	34.60	25159151
528 (in isoform 2)	Phosphorylation	-	34.60	21406692
529	Phosphorylation	LSERTNSSDSERSPD HHHCCCCCCCCCCCC	47.42	25159151
529 (in isoform 2)	Phosphorylation	-	47.42	21406692
531	Phosphorylation	ERTNSSDSERSPDLG HCCCCCCCCCCCCCC	36.54	23927012
531 (in isoform 2)	Phosphorylation	-	36.54	21406692
534	Phosphorylation	NSSDSERSPDLGHST CCCCCCCCCCCCCCC	20.79	29255136
534 (in isoform 2)	Phosphorylation	-	20.79	21406692
540	O-linked_Glycosylation	RSPDLGHSTQIPRKV CCCCCCCCCCCCHHH	21.87	29351928
540	Phosphorylation	RSPDLGHSTQIPRKV CCCCCCCCCCCCHHH	21.87	23927012
541	Phosphorylation	SPDLGHSTQIPRKVV CCCCCCCCCCCHHHH	25.50	23927012
549	Phosphorylation	QIPRKVVYDQLNQIL CCCHHHHHHHHHHHH	10.85	-
593	Phosphorylation	QRKPVVCTCSTVEVQ CCCCEEEECCHHHHH	9.62	27732954
595	Phosphorylation	KPVVCTCSTVEVQAV CCEEEECCHHHHHHH	19.82	27732954
596	Phosphorylation	PVVCTCSTVEVQAVL CEEEECCHHHHHHHH	23.88	27732954
613	Phosphorylation	LLTRIQRYCNCNSSM HHHHHHHHHCCCCCC	3.31	-
633	Phosphorylation	VAAVGGQSYLSSILR EEEECCHHHHHHHHH	31.17	28152594
634	Phosphorylation	AAVGGQSYLSSILRF EEECCHHHHHHHHHH	11.60	28152594
636	Phosphorylation	VGGQSYLSSILRFFV ECCHHHHHHHHHHHH	13.70	28152594
637	Phosphorylation	GGQSYLSSILRFFVK CCHHHHHHHHHHHHH	24.05	24719451
651	Phosphorylation	KSLANKTSDWLGYMR HHHCCCCCHHHHCCE	28.53	-
671	Acetylation	LGSHPVAKYLGSVDS CCCCHHHHHHCCCCC	41.04	25953088
672	Phosphorylation	GSHPVAKYLGSVDSK CCCHHHHHHCCCCCH	13.42	-
680	Phosphorylation	LGSVDSKYSSSFLDS HCCCCCHHCHHHHCC	20.10	-
687	Phosphorylation	YSSSFLDSGWRDLFS HCHHHHCCCHHHHHH	42.26	-
719	Phosphorylation	QYVNGAATTHQLPVA HHHCCCCCCCCCCHH	25.03	22210691
731	Phosphorylation	PVAEAMLTCRHKFPD CHHHHHHHCCCCCCC	8.39	22210691
760	Phosphorylation	KVGLVEDSPSTAGDG EEEEECCCCCCCCCC	13.77	22199227
762	Phosphorylation	GLVEDSPSTAGDGDD EEECCCCCCCCCCCC	34.54	22199227
763	Phosphorylation	LVEDSPSTAGDGDDS EECCCCCCCCCCCCC	37.74	22199227
770	Phosphorylation	TAGDGDDSPVVSLTV CCCCCCCCCEEEEEE	25.08	22199227
774	Phosphorylation	GDDSPVVSLTVPSTS CCCCCEEEEEECCCC	20.68	28450419
776	Phosphorylation	DSPVVSLTVPSTSPP CCCEEEEEECCCCCC	23.90	28450419
779	Phosphorylation	VVSLTVPSTSPPSSS EEEEEECCCCCCCCC	36.86	30278072
780	Phosphorylation	VSLTVPSTSPPSSSG EEEEECCCCCCCCCC	38.90	30278072
781	Phosphorylation	SLTVPSTSPPSSSGL EEEECCCCCCCCCCC	38.87	30278072
784	Phosphorylation	VPSTSPPSSSGLSRD ECCCCCCCCCCCCCC	40.29	28450419
785	Phosphorylation	PSTSPPSSSGLSRDA CCCCCCCCCCCCCCC	33.91	28450419
786	Phosphorylation	STSPPSSSGLSRDAT CCCCCCCCCCCCCCC	48.36	28450419
789	Phosphorylation	PPSSSGLSRDATATP CCCCCCCCCCCCCCC	31.47	28450419
795	Phosphorylation	LSRDATATPPSSPSM CCCCCCCCCCCCCCH	31.23	27251275
798	Phosphorylation	DATATPPSSPSMSSA CCCCCCCCCCCHHHH	56.96	27251275
799	Phosphorylation	ATATPPSSPSMSSAL CCCCCCCCCCHHHHE	27.11	27251275
814	O-linked_Glycosylation	AIVGSPNSPYGDVIG ECCCCCCCCCCCCEE	23.92	29351928
844	Phosphorylation	EGDKRDASSKNTLKS CCCCCCCCCCHHHHH	46.24	-
845	Phosphorylation	GDKRDASSKNTLKSV CCCCCCCCCHHHHHH	31.48	-
848	Phosphorylation	RDASSKNTLKSVFRS CCCCCCHHHHHHHHH	39.02	-
851	Phosphorylation	SSKNTLKSVFRSVQV CCCHHHHHHHHHEEE	29.60	23401153
855	Phosphorylation	TLKSVFRSVQVSRLP HHHHHHHHEEECCCC	12.87	29449344
859	Phosphorylation	VFRSVQVSRLPHSGE HHHHEEECCCCCCCC	15.82	29449344
870	Phosphorylation	HSGEAQLSGTMAMTV CCCCCCCCCEEEEEE	21.82	30387612
872	Phosphorylation	GEAQLSGTMAMTVVT CCCCCCCEEEEEEEE	9.81	30387612
884	Acetylation	VVTKEKNKKVPTIFL EEECCCCCCCCEEEE	67.24	18585905
903	Ubiquitination	REKEVDSKSQVIEGI CHHHCCCHHHHHHHH	40.21	-
918	Malonylation	SRLICSAKQQQTMLR HHHHHCHHHHCCEEE	32.14	26320211

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
278	S	Phosphorylation	Kinase	CSNK2A1	P68400	GPS
278	S	Phosphorylation	Kinase	CK2-FAMILY	-	GPS
278	S	Phosphorylation	Kinase	CK2_GROUP	-	PhosphoELM

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of PACS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of PACS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
GGA3_HUMAN	GGA3	physical	16977309
CSK21_HUMAN	CSNK2A1	physical	16977309
SORL_HUMAN	SORL1	physical	17855360
PTPRG_HUMAN	PTPRG	physical	27173435
FP100_HUMAN	C17orf70	physical	27173435

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
615009	Mental retardation, autosomal dominant 17 (MRD17)
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of PACS1_HUMAN

Related Literatures of Post-Translational Modification

Acetylation
Reference	PubMed
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-46, AND MASS SPECTROMETRY.	19413330 [Abstract]
Phosphorylation
Reference	PubMed
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-379; SER-381; SER-430;SER-495; THR-504; SER-528; SER-529 AND SER-534, AND MASS SPECTROMETRY.	18669648 [Abstract]
"ATM and ATR substrate analysis reveals extensive protein networksresponsive to DNA damage."; Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III,Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N.,Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J.; Science 316:1160-1166(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407 AND SER-410, ANDMASS SPECTROMETRY.	17525332 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, PHOSPHORYLATION [LARGESCALE ANALYSIS] AT THR-46, AND MASS SPECTROMETRY.	19413330 [Abstract]
"Large-scale characterization of HeLa cell nuclear phosphoproteins."; Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-46, AND MASSSPECTROMETRY.	15302935 [Abstract]
"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer."; Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.; Cell 131:1190-1203(2007). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-251, AND MASSSPECTROMETRY.	18083107 [Abstract]