SNX30_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: SNX30_HUMAN
• UniProt AC: Q5VWJ9
• Protein Name: Sorting nexin-30
• Gene Name: SNX30
• Organism: Homo sapiens (Human).
• Sequence Length: 437
• Protein Description: May be involved in several stages of intracellular trafficking..
• Protein Sequence: MAGGPPKALPSTGPHSLRDMPHPLAGSSSEEAVGGDSTPSPDLLMARSFGDKDLILPNGGTPAGTSSPASSSSLLNRLQLDDDIDGETRDLFVIVDDPKKHVCTMETYITYRITTKSTRVEFDLPEYSVRRRYQDFDWLRSKLEESQPTHLIPPLPEKFVVKGVVDRFSEEFVETRRKALDKFLKRITDHPVLSFNEHFNIFLTAKDLNAYKKQGIALLTRMGESVKHVTGGYKLRTRPLEFAAIGDYLDTFALKLGTIDRIAQRIIKEEIEYLVELREYGPVYSTWSALEGELAEPLEGVSACIGNCSTALEELTDDMTEDFLPVLREYILYSDSMKSVLKKRDQVQAEYEAKLEAVALRKEDRPKVPADVEKCQDRMECFNADLKADMERWQNNKRQDFRQLLMGMADKNIQYYEKCLMAWESIIPLLQEKQEAK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
11	Phosphorylation	GPPKALPSTGPHSLR CCCCCCCCCCCCCCC	47.01	28348404
12	Phosphorylation	PPKALPSTGPHSLRD CCCCCCCCCCCCCCC	53.44	28348404
16	Phosphorylation	LPSTGPHSLRDMPHP CCCCCCCCCCCCCCC	28.38	22985185
27	Phosphorylation	MPHPLAGSSSEEAVG CCCCCCCCCCCCCCC	25.69	25850435
28	Phosphorylation	PHPLAGSSSEEAVGG CCCCCCCCCCCCCCC	40.63	25850435
29	Phosphorylation	HPLAGSSSEEAVGGD CCCCCCCCCCCCCCC	40.95	25850435
37	Phosphorylation	EEAVGGDSTPSPDLL CCCCCCCCCCCHHHE	45.55	29255136
38	Phosphorylation	EAVGGDSTPSPDLLM CCCCCCCCCCHHHEE	32.31	29255136
40	Phosphorylation	VGGDSTPSPDLLMAR CCCCCCCCHHHEEHH	31.00	29255136
48	Phosphorylation	PDLLMARSFGDKDLI HHHEEHHCCCCCCEE	24.84	25850435
61	Phosphorylation	LILPNGGTPAGTSSP EECCCCCCCCCCCCC	16.03	26657352
65	Phosphorylation	NGGTPAGTSSPASSS CCCCCCCCCCCCCCH	28.30	29255136
66	Phosphorylation	GGTPAGTSSPASSSS CCCCCCCCCCCCCHH	33.15	29255136
67	Phosphorylation	GTPAGTSSPASSSSL CCCCCCCCCCCCHHH	25.07	29255136
70	Phosphorylation	AGTSSPASSSSLLNR CCCCCCCCCHHHHHH	33.85	29255136
71	Phosphorylation	GTSSPASSSSLLNRL CCCCCCCCHHHHHHC	26.50	20363803
72	Phosphorylation	TSSPASSSSLLNRLQ CCCCCCCHHHHHHCC	23.62	25850435
73	Phosphorylation	SSPASSSSLLNRLQL CCCCCCHHHHHHCCC	38.53	29978859
99	Ubiquitination	FVIVDDPKKHVCTME EEEECCCCCEEEEEE	63.61	29967540
101	Ubiquitination	IVDDPKKHVCTMETY EECCCCCEEEEEEEE	26.47	23503661
117	Ubiquitination	TYRITTKSTRVEFDL EEEEECCCCEEEECC	21.25	22817900
121	Ubiquitination	TTKSTRVEFDLPEYS ECCCCEEEECCCCHH	30.10	22817900
142	Ubiquitination	DFDWLRSKLEESQPT CHHHHHHHCHHCCCC	54.18	23503661
158	Ubiquitination	LIPPLPEKFVVKGVV CCCCCCCHHEEEEHH	41.33	22817900
158	Acetylation	LIPPLPEKFVVKGVV CCCCCCCHHEEEEHH	41.33	7380025
162	Ubiquitination	LPEKFVVKGVVDRFS CCCHHEEEEHHHHCC	40.46	21906983
162	Acetylation	LPEKFVVKGVVDRFS CCCHHEEEEHHHHCC	40.46	7380035
225	Phosphorylation	LLTRMGESVKHVTGG HHHHCCCCEEECCCC	30.64	28857561
230	Phosphorylation	GESVKHVTGGYKLRT CCCEEECCCCCCCCC	25.30	24719451
230	O-linked_Glycosylation	GESVKHVTGGYKLRT CCCEEECCCCCCCCC	25.30	30379171
233	Phosphorylation	VKHVTGGYKLRTRPL EEECCCCCCCCCCCC	14.27	24719451
234	Ubiquitination	KHVTGGYKLRTRPLE EECCCCCCCCCCCCC	34.46	29967540
258	Phosphorylation	TFALKLGTIDRIAQR HHHHHHCCHHHHHHH	30.09	28857561
330	Phosphorylation	FLPVLREYILYSDSM HHHHHHHHHHHCHHH	6.98	-
334	Phosphorylation	LREYILYSDSMKSVL HHHHHHHCHHHHHHH	21.55	21601212
354	Acetylation	VQAEYEAKLEAVALR HHHHHHHHHHHHHCC	34.61	25953088
379	Sulfoxidation	VEKCQDRMECFNADL HHHHHHHHHHHHCHH	7.66	21406390
416	Phosphorylation	ADKNIQYYEKCLMAW HHHCHHHHHHHHHHH	7.79	22817900

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of SNX30_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of SNX30_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of SNX30_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of SNX30_HUMAN !!

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"A quantitative atlas of mitotic phosphorylation.";
Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-40, AND MASSSPECTROMETRY.
PubMed: 18669648