dbPTM

IPPK_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	IPPK_HUMAN
UniProt AC	Q9H8X2
Protein Name	Inositol-pentakisphosphate 2-kinase
Gene Name	IPPK
Organism	Homo sapiens (Human).
Sequence Length	491
Subcellular Localization	Cytoplasm. Nucleus.
Protein Description	Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate). InsP6 is involved in many processes such as mRNA export, non-homologous end-joining, endocytosis, ion channel regulation. It also protects cells from TNF-alpha-induced apoptosis..
Protein Sequence	MEEGKMDENEWGYHGEGNKSLVVAHAQRCVVLRFLKFPPNRKKTSEEIFQHLQNIVDFGKNVMKEFLGENYVHYGEVVQLPLEFVKQLCLKIQSERPESRCDKDLDTLSGYAMCLPNLTRLQTYRFAEHRPILCVEIKPKCGFIPFSSDVTHEMKHKVCRYCMHQHLKVATGKWKQISKYCPLDLYSGNKQRMHFALKSLLQEAQNNLKIFKNGELIYGCKDARSPVADWSELAHHLKPFFFPSNGLASGPHCTRAVIRELVHVITRVLLSGSDKGRAGTLSPGLGPQGPRVCEASPFSRSLRCQGKNTPERSGLPKGCLLYKTLQVQMLDLLDIEGLYPLYNRVERYLEEFPEERKTLQIDGPYDEAFYQKLLDLSTEDDGTVAFALTKVQQYRVAMTAKDCSIMIALSPCLQDASSDQRPVVPSSRSRFAFSVSVLDLDLKPYESIPHQYKLDGKIVNYYSKTVRAKDNAVMSTRFKESEDCTLVLHKV

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
109	Phosphorylation	DKDLDTLSGYAMCLP CCCHHHHHHHHHHHC	31.67	29414761
119	Phosphorylation	AMCLPNLTRLQTYRF HHHHCCCCHHHEEEC	35.65	29414761
173	Ubiquitination	HLKVATGKWKQISKY HHHHHCCCHHHHHHC	47.03	29967540
179	Ubiquitination	GKWKQISKYCPLDLY CCHHHHHHCCCCCCC	53.12	29967540
186	Phosphorylation	KYCPLDLYSGNKQRM HCCCCCCCCCCHHHH	17.75	30576142
187	Phosphorylation	YCPLDLYSGNKQRMH CCCCCCCCCCHHHHH	43.09	30576142
190	Ubiquitination	LDLYSGNKQRMHFAL CCCCCCCHHHHHHHH	42.69	29967540
198	Methylation	QRMHFALKSLLQEAQ HHHHHHHHHHHHHHH	35.31	115971491
209	Ubiquitination	QEAQNNLKIFKNGEL HHHHHHCCCCCCCEE	48.50	29967540
238	Acetylation	SELAHHLKPFFFPSN HHHHHHHCCCCCCCC	35.11	26051181
266	Phosphorylation	RELVHVITRVLLSGS HHHHHHHHHHHHCCC	17.40	25690035
275	Ubiquitination	VLLSGSDKGRAGTLS HHHCCCCCCCCCCCC	52.58	27667366
280	Phosphorylation	SDKGRAGTLSPGLGP CCCCCCCCCCCCCCC	24.07	23186163
282	Phosphorylation	KGRAGTLSPGLGPQG CCCCCCCCCCCCCCC	19.43	25159151
296	Phosphorylation	GPRVCEASPFSRSLR CCCCEECCCCCHHHC	12.27	26699800
299	Phosphorylation	VCEASPFSRSLRCQG CEECCCCCHHHCCCC	25.09	26699800
309	Phosphorylation	LRCQGKNTPERSGLP HCCCCCCCCCCCCCC	29.97	25056879
317	Ubiquitination	PERSGLPKGCLLYKT CCCCCCCCCCHHHHH	68.26	29967540
357	Ubiquitination	EEFPEERKTLQIDGP HHCCHHHCCCCCCCC	57.79	21906983
404	Phosphorylation	AMTAKDCSIMIALSP EECCCCCCEEEEEHH	25.89	-
418	Phosphorylation	PCLQDASSDQRPVVP HHHCCCCCCCCCCCC	39.21	-
426	Phosphorylation	DQRPVVPSSRSRFAF CCCCCCCCCCCCEEE	27.12	23898821
457	Ubiquitination	HQYKLDGKIVNYYSK CEEEECCEEEEEEEC	43.05	29967540
457	Acetylation	HQYKLDGKIVNYYSK CEEEECCEEEEEEEC	43.05	26051181
461	Phosphorylation	LDGKIVNYYSKTVRA ECCEEEEEEECEEEC	9.75	29496907
462	Phosphorylation	DGKIVNYYSKTVRAK CCEEEEEEECEEECC	9.85	29496907
479	Ubiquitination	AVMSTRFKESEDCTL EEEECCCCCCCCCEE	57.97	29967540
490	Ubiquitination	DCTLVLHKV------ CCEEEEEEC------	45.54	29967540

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of IPPK_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of IPPK_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of IPPK_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LPAR1_HUMAN	LPAR1	physical	28514442
TYRO3_HUMAN	TYRO3	physical	28514442
ENPP4_HUMAN	ENPP4	physical	28514442
SELT_HUMAN	SELT	physical	28514442
SL9A1_HUMAN	SLC9A1	physical	28514442
SC5D_HUMAN	SC5D	physical	28514442
CERS4_HUMAN	CERS4	physical	28514442
CERS5_HUMAN	CERS5	physical	28514442
AT2B3_HUMAN	ATP2B3	physical	28514442
TM87B_HUMAN	TMEM87B	physical	28514442
MTR1L_HUMAN	GPR50	physical	28514442
ZDH17_HUMAN	ZDHHC17	physical	28514442
ATP9A_HUMAN	ATP9A	physical	28514442
AR6P1_HUMAN	ARL6IP1	physical	28514442
ZDH18_HUMAN	ZDHHC18	physical	28514442
COL12_HUMAN	COLEC12	physical	28514442
AT2B4_HUMAN	ATP2B4	physical	28514442
CHP3_HUMAN	TESC	physical	28514442
G137A_HUMAN	GPR137	physical	28514442
GPC5B_HUMAN	GPRC5B	physical	28514442
TM186_HUMAN	TMEM186	physical	28514442
SNX13_HUMAN	SNX13	physical	28514442
MAN1_HUMAN	LEMD3	physical	28514442
CD97_HUMAN	CD97	physical	28514442
SNX14_HUMAN	SNX14	physical	28514442
CIA30_HUMAN	NDUFAF1	physical	28514442
ECSIT_HUMAN	ECSIT	physical	28514442
ADCY6_HUMAN	ADCY6	physical	28514442
GOGA5_HUMAN	GOLGA5	physical	28514442
RETR3_HUMAN	FAM134C	physical	28514442
CKAP4_HUMAN	CKAP4	physical	28514442
SCAP_HUMAN	SCAP	physical	28514442
CD032_HUMAN	C4orf32	physical	28514442
RTN2_HUMAN	RTN2	physical	28514442
FZD8_HUMAN	FZD8	physical	28514442
TMM11_HUMAN	TMEM11	physical	28514442
TM87A_HUMAN	TMEM87A	physical	28514442
RMND1_HUMAN	RMND1	physical	28514442
STX4_HUMAN	STX4	physical	28514442
SERC1_HUMAN	SERINC1	physical	28514442
T161B_HUMAN	TMEM161B	physical	28514442
NU2M_HUMAN	ND2	physical	28514442
CXCR4_HUMAN	CXCR4	physical	28514442
CERS6_HUMAN	CERS6	physical	28514442
LMBR1_HUMAN	LMBR1	physical	28514442
NDC1_HUMAN	NDC1	physical	28514442
STX8_HUMAN	STX8	physical	28514442
MPZL1_HUMAN	MPZL1	physical	28514442
ZNT5_HUMAN	SLC30A5	physical	28514442
CTR3_HUMAN	SLC7A3	physical	28514442
TM223_HUMAN	TMEM223	physical	28514442
REEP6_HUMAN	REEP6	physical	28514442
ZDHC9_HUMAN	ZDHHC9	physical	28514442
YIPF4_HUMAN	YIPF4	physical	28514442
LNP_HUMAN	KIAA1715	physical	28514442
XYLK_HUMAN	FAM20B	physical	28514442
SMAD5_HUMAN	SMAD5	physical	28514442
FITM2_HUMAN	FITM2	physical	28514442
EXTL2_HUMAN	EXTL2	physical	28514442
ARL10_HUMAN	ARL10	physical	28514442
OCAD1_HUMAN	OCIAD1	physical	28514442
CJ035_HUMAN	C10orf35	physical	28514442
CGAT2_HUMAN	CSGALNACT2	physical	28514442
EXTL3_HUMAN	EXTL3	physical	28514442
PIGW_HUMAN	PIGW	physical	28514442
ITPR2_HUMAN	ITPR2	physical	28514442
MBOA7_HUMAN	MBOAT7	physical	28514442
GPC5C_HUMAN	GPRC5C	physical	28514442
PPAL_HUMAN	ACP2	physical	28514442
VEZA_HUMAN	VEZT	physical	28514442
MRS2_HUMAN	MRS2	physical	28514442
STXB3_HUMAN	STXBP3	physical	28514442
MFSD8_HUMAN	MFSD8	physical	28514442
HACD2_HUMAN	PTPLB	physical	28514442
GP1BB_HUMAN	GP1BB	physical	28514442
KTN1_HUMAN	KTN1	physical	28514442
MBOA5_HUMAN	LPCAT3	physical	28514442
LEG3_HUMAN	LGALS3	physical	28514442
VAMP3_HUMAN	VAMP3	physical	28514442
GOGB1_HUMAN	GOLGB1	physical	28514442
CD47_HUMAN	CD47	physical	28514442
LRC8A_HUMAN	LRRC8A	physical	28514442
PCD19_HUMAN	PCDH19	physical	28514442
KDSR_HUMAN	KDSR	physical	28514442
DGLB_HUMAN	DAGLB	physical	28514442
TSN15_HUMAN	TSPAN15	physical	28514442
CSCL2_HUMAN	TMEM63B	physical	28514442
AGRL3_HUMAN	LPHN3	physical	28514442
ARV1_HUMAN	ARV1	physical	28514442
LCLT1_HUMAN	LCLAT1	physical	28514442
ZDH13_HUMAN	ZDHHC13	physical	28514442
ACAD9_HUMAN	ACAD9	physical	28514442
CERS2_HUMAN	CERS2	physical	28514442
GP108_HUMAN	GPR108	physical	28514442
TTYH3_HUMAN	TTYH3	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of IPPK_HUMAN

Related Literatures of Post-Translational Modification