FZD8_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: FZD8_HUMAN
• UniProt AC: Q9H461
• Protein Name: Frizzled-8
• Gene Name: FZD8
• Organism: Homo sapiens (Human).
• Sequence Length: 694
• Subcellular Localization: Membrane; Multi-pass membrane protein. Golgi apparatus. Cell membrane; Multi-pass membrane protein. Colocalizes with GOPC at the Golgi apparatus..
• Protein Description: Receptor for Wnt proteins. Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalosomes. The beta-catenin canonical signaling pathway leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. Coreceptor along with RYK of Wnt proteins, such as WNT1..
• Protein Sequence: MEWGYLLEVTSLLAALALLQRSSGAAAASAKELACQEITVPLCKGIGYNYTYMPNQFNHDTQDEAGLEVHQFWPLVEIQCSPDLKFFLCSMYTPICLEDYKKPLPPCRSVCERAKAGCAPLMRQYGFAWPDRMRCDRLPEQGNPDTLCMDYNRTDLTTAAPSPPRRLPPPPPGEQPPSGSGHGRPPGARPPHRGGGRGGGGGDAAAPPARGGGGGGKARPPGGGAAPCEPGCQCRAPMVSVSSERHPLYNRVKTGQIANCALPCHNPFFSQDERAFTVFWIGLWSVLCFVSTFATVSTFLIDMERFKYPERPIIFLSACYLFVSVGYLVRLVAGHEKVACSGGAPGAGGAGGAGGAAAGAGAAGAGAGGPGGRGEYEELGAVEQHVRYETTGPALCTVVFLLVYFFGMASSIWWVILSLTWFLAAGMKWGNEAIAGYSQYFHLAAWLVPSVKSIAVLALSSVDGDPVAGICYVGNQSLDNLRGFVLAPLVIYLFIGTMFLLAGFVSLFRIRSVIKQQDGPTKTHKLEKLMIRLGLFTVLYTVPAAVVVACLFYEQHNRPRWEATHNCPCLRDLQPDQARRPDYAVFMLKYFMCLVVGITSGVWVWSGKTLESWRSLCTRCCWASKGAAVGGGAGATAAGGGGGPGGGGGGGPGGGGGPGGGGGSLYSDVSTGLTWRSGTASSVSYPKQMPLSQV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEWGYLLEVTSL ---CCCHHHHHHHHH	14.80	24043423
10	Phosphorylation	WGYLLEVTSLLAALA CHHHHHHHHHHHHHH	12.32	24043423
11	Phosphorylation	GYLLEVTSLLAALAL HHHHHHHHHHHHHHH	26.93	24043423
49	N-linked_Glycosylation	LCKGIGYNYTYMPNQ CCCCCCCCCEECCCC	19.91	UniProtKB CARBOHYD
152	N-linked_Glycosylation	DTLCMDYNRTDLTTA CCEEECCCCCCCCCC	35.79	UniProtKB CARBOHYD
154	Phosphorylation	LCMDYNRTDLTTAAP EEECCCCCCCCCCCC	31.55	23532336
162	Phosphorylation	DLTTAAPSPPRRLPP CCCCCCCCCCCCCCC	42.69	26091039
376	Phosphorylation	GPGGRGEYEELGAVE CCCCCCCHHHHCCEE	19.96	-
475	N-linked_Glycosylation	AGICYVGNQSLDNLR CEEEEECCCCHHCCH	20.44	UniProtKB CARBOHYD
515	Ubiquitination	FRIRSVIKQQDGPTK HHHHHHHHHCCCCCC	39.49	-
540	Phosphorylation	LGLFTVLYTVPAAVV HCHHHHHHHHHHHHH	11.01	-
541	Phosphorylation	GLFTVLYTVPAAVVV CHHHHHHHHHHHHHH	18.82	-
681	Phosphorylation	TWRSGTASSVSYPKQ EECCCCCCCCCCCCC	30.98	28348404
682	Phosphorylation	WRSGTASSVSYPKQM ECCCCCCCCCCCCCC	16.78	24961811
684	Phosphorylation	SGTASSVSYPKQMPL CCCCCCCCCCCCCCC	37.35	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of FZD8_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of FZD8_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of FZD8_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
LRP6_HUMAN	LRP6	physical	15908424
LRP5_HUMAN	LRP5	physical	11448771
LRP6_HUMAN	LRP6	physical	11448771

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.