PCDA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PCDA2_HUMAN
• UniProt AC: Q9Y5H9
• Protein Name: Protocadherin alpha-2
• Gene Name: PCDHA2
• Organism: Homo sapiens (Human).
• Sequence Length: 948
• Subcellular Localization: Cell membrane; Single-pass type I membrane protein.
• Protein Description: Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain..
• Protein Sequence: MASSIRRGRGAWTRLLSLLLLAAWEVGSGQLRYSVPEEAKHGTFVGRIAQDLGLELEELVPRLFRVASKRHGDLLEVNLQNGILFVNSRIDREELCGRSAECSIHVEVIVDRPLQVFHVEVEVKDINDNPPIFPMTVKTIRFPESRLLDSRFPLEGASDADIGVNALLSYKLSSSEFFFLDIQANDELSESLSLVLGKSLDREETAEVNLLLVATDGGKPELTGTVQILIKVLDVNDNEPTFAQSVYKVKLLENTANGTLVVKLNASDADEGPNSEIVYSLGSDVSSTIQTKFTIDPISGEIRTKGKLDYEEAKSYEIQVTATDKGTPSMSGHCKISLKLVDINDNTPEVSITSLSLPISENASLGTVIALITVSDRDSGTNGHVTCSLTPHVPFKLVSTFKNYYSLVLDSALDRESVSAYELVVTARDGGSPSLWATTSVSIEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAWDADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEEVELLQFQVSARDAGVPPLGSNVTLQVFVLDENDNAPALLAPRAGTAAGAVSELVPWSVGAGHVVAKVRAVDADSGYNAWLSYELQLGTGSARIPFRVGLYTGEISTTRALDEADSPRHRLLVLVKDHGEPALTATATVLVSLVESGQAPKASSRAWVGAAGSEATLVDVNVYLIIAICAVSSLLVLTVLLYTALRCSVPPTEGARAPGKPTLVCSSAVGSWSYSQQRRQRVCSGEDPPKTDLMAFSPSLSQGPDSAEEKQLSESEYVGKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
17	Phosphorylation	GAWTRLLSLLLLAAW HHHHHHHHHHHHHHH	22.89	-
33	Phosphorylation	VGSGQLRYSVPEEAK HCCCCCEECCCHHHC	23.70	-
257	N-linked_Glycosylation	KLLENTANGTLVVKL EEEEECCCCEEEEEE	41.78	UniProtKB CARBOHYD
265	N-linked_Glycosylation	GTLVVKLNASDADEG CEEEEEECCCCCCCC	31.51	UniProtKB CARBOHYD
321	Phosphorylation	KSYEIQVTATDKGTP CEEEEEEEEECCCCC	13.89	-
323	Phosphorylation	YEIQVTATDKGTPSM EEEEEEEECCCCCCC	28.95	-
362	N-linked_Glycosylation	LSLPISENASLGTVI EECCCCCCCCCCEEE	28.21	UniProtKB CARBOHYD
506	Phosphorylation	VGERALSSYVSVHAE HHHHHHHHEEEEEEC	30.33	-
514	Phosphorylation	YVSVHAESGKVYALQ EEEEEECCCCEEEEC	44.70	29759185
548	N-linked_Glycosylation	GVPPLGSNVTLQVFV CCCCCCCCEEEEEEE	29.06	UniProtKB CARBOHYD
601	Phosphorylation	VRAVDADSGYNAWLS EEEEECCCCCCEEEE	44.92	18187866
603	Phosphorylation	AVDADSGYNAWLSYE EEECCCCCCEEEEEE	12.98	-
660	Phosphorylation	DHGEPALTATATVLV CCCCCCCEEEEEEHH	24.86	-
662	Phosphorylation	GEPALTATATVLVSL CCCCCEEEEEEHHHH	20.02	-
664	Phosphorylation	PALTATATVLVSLVE CCCEEEEEEHHHHHH	15.26	-
679	Phosphorylation	SGQAPKASSRAWVGA CCCCCCCCCCEECCC	26.87	-
680	Phosphorylation	GQAPKASSRAWVGAA CCCCCCCCCEECCCC	30.77	-
738	Phosphorylation	ARAPGKPTLVCSSAV CCCCCCCEEEEECCC	35.00	-
743	Phosphorylation	KPTLVCSSAVGSWSY CCEEEEECCCCCCCH	23.11	22468782
747	Phosphorylation	VCSSAVGSWSYSQQR EEECCCCCCCHHHHH	13.27	22210691
749	Phosphorylation	SSAVGSWSYSQQRRQ ECCCCCCCHHHHHHH	19.32	22210691
750	Phosphorylation	SAVGSWSYSQQRRQR CCCCCCCHHHHHHHH	12.30	28857561
751	Phosphorylation	AVGSWSYSQQRRQRV CCCCCCHHHHHHHHH	17.83	28857561
760	Phosphorylation	QRRQRVCSGEDPPKT HHHHHHCCCCCCCCC	42.22	23532336
767	Phosphorylation	SGEDPPKTDLMAFSP CCCCCCCCCCEEECC	39.89	29759185
773	Phosphorylation	KTDLMAFSPSLSQGP CCCCEEECCCHHCCC	12.21	29759185
782	Phosphorylation	SLSQGPDSAEEKQLS CHHCCCCCHHHHHCC	40.49	29759185
789	Phosphorylation	SAEEKQLSESEYVGK CHHHHHCCCCCCCCC	36.26	28387310
806	Phosphorylation	QPNPDWRYSASLRAG CCCCCCCCEEEHHCC	12.34	-
807	Phosphorylation	PNPDWRYSASLRAGM CCCCCCCEEEHHCCC	11.65	24719451
809	Phosphorylation	PDWRYSASLRAGMHS CCCCCEEEHHCCCCC	16.67	24719451
816	Phosphorylation	SLRAGMHSSVHLEEA EHHCCCCCCEEHHHC	25.76	28857561
817	Phosphorylation	LRAGMHSSVHLEEAG HHCCCCCCEEHHHCC	10.01	24719451
819 (in isoform 2)	Phosphorylation	-	29.48	23663014
820 (in isoform 2)	Phosphorylation	-	6.28	23663014
821 (in isoform 2)	Phosphorylation	-	30.81	23663014
824 (in isoform 2)	Phosphorylation	-	23.81	23663014
875	Ubiquitination	KYGPGNPKQSGPGEL ECCCCCCCCCCCCCC	62.18	33845483
891	Phosphorylation	DKFIIPGSPAIISIR CCEEECCCCEEEEEE	13.05	27050516
896	Phosphorylation	PGSPAIISIRQEPTN CCCCEEEEEECCCCC	12.95	27732954
902	Phosphorylation	ISIRQEPTNSQIDKS EEEECCCCCCCCCHH	46.91	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PCDA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PCDA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PCDA2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of PCDA2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.