| UniProt ID | DNM3L_HUMAN | |
|---|---|---|
| UniProt AC | Q9UJW3 | |
| Protein Name | DNA (cytosine-5)-methyltransferase 3-like | |
| Gene Name | DNMT3L | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 386 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Catalytically inactive regulatory factor of DNA methyltransferases that can either promote or inhibit DNA methylation depending on the context (By similarity). Essential for the function of DNMT3A and DNMT3B: activates DNMT3A and DNMT3B by binding to their catalytic domain. [PubMed: 17687327 Acts by accelerating the binding of DNA and S-adenosyl-L-methionine (AdoMet) to the methyltransferases and dissociates from the complex after DNA binding to the methyltransferases] | |
| Protein Sequence | MAAIPALDPEAEPSMDVILVGSSELSSSVSPGTGRDLIAYEVKANQRNIEDICICCGSLQVHTQHPLFEGGICAPCKDKFLDALFLYDDDGYQSYCSICCSGETLLICGNPDCTRCYCFECVDSLVGPGTSGKVHAMSNWVCYLCLPSSRSGLLQRRRKWRSQLKAFYDRESENPLEMFETVPVWRRQPVRVLSLFEDIKKELTSLGFLESGSDPGQLKHVVDVTDTVRKDVEEWGPFDLVYGATPPLGHTCDRPPSWYLFQFHRLLQYARPKPGSPRPFFWMFVDNLVLNKEDLDVASRFLEMEPVTIPDVHGGSLQNAVRVWSNIPAIRSRHWALVSEEELSLLAQNKQSSKLAAKWPTKLVKNCFLPLREYFKYFSTELTSSL | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 259 | Phosphorylation | CDRPPSWYLFQFHRL CCCCCCCHHHHHHHH | 11.28 | - | |
| 269 | Phosphorylation | QFHRLLQYARPKPGS HHHHHHHHCCCCCCC | 12.44 | - | |
| 325 | Phosphorylation | QNAVRVWSNIPAIRS HHHHHHHHCCHHHHH | 23.25 | 24719451 | |
| 325 (in isoform 2) | Phosphorylation | - | 23.25 | 24719451 | |
| 332 (in isoform 2) | Phosphorylation | - | 23.53 | 26434776 | |
| 354 | "N6,N6-dimethyllysine" | AQNKQSSKLAAKWPT HHCHHHHHHHHHCCH | 47.60 | - | |
| 354 | Methylation | AQNKQSSKLAAKWPT HHCHHHHHHHHHCCH | 47.60 | - |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DNM3L_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DNM3L_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DNM3L_HUMAN !! | ||||||
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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