CRBL2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: CRBL2_HUMAN
• UniProt AC: O60519
• Protein Name: cAMP-responsive element-binding protein-like 2
• Gene Name: CREBL2
• Organism: Homo sapiens (Human).
• Sequence Length: 120
• Subcellular Localization: Nucleus.
• Protein Description: Probable regulator of CREB1 transcriptional activity which is involved in adipose cells differentiation. May also play a regulatory role in the cell cycle. Identification in a chromosomal region frequently deleted in various cancers suggests that it might act as a tumor suppressor..
• Protein Sequence: MDDSKVVGGKVKKPGKRGRKPAKIDLKAKLERSRQSARECRARKKLRYQYLEELVSSRERAICALREELEMYKQWCMAMDQGKIPSEIKALLTGEEQNKSQQNSSRHTKAGKTDANSNSW

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MDDSKVVGGKV ----CCHHCCCCCCC	24.08	29083192
56	Phosphorylation	QYLEELVSSRERAIC HHHHHHHHHHHHHHH	35.98	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of CRBL2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of CRBL2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of CRBL2_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of CRBL2_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.