| UniProt ID | DMTF1_HUMAN | |
|---|---|---|
| UniProt AC | Q9Y222 | |
| Protein Name | Cyclin-D-binding Myb-like transcription factor 1 | |
| Gene Name | DMTF1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 760 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Transcriptional activator which activates the CDKN2A/ARF locus in response to Ras-Raf signaling, thereby promoting p53/TP53-dependent growth arrest (By similarity). Binds to the consensus sequence 5'-CCCG[GT]ATGT-3' (By similarity). Isoform 1 may cooperate with MYB to activate transcription of the ANPEP gene. Isoform 2 may antagonize transcriptional activation by isoform 1.. | |
| Protein Sequence | MSTVEEDSDTVTVETVNSVTLTQDTEGNLILHCPQNEADEIDSEDSIEPPHKRLCLSSEDDQSIDDSTPCISVVALPLSENDQSFEVTMTATTEVADDEVTEGTVTQIQILQNEQLDEISPLGNEEVSAVSQAWFTTKEDKDSLTNKGHKWKQGMWSKEEIDILMNNIERYLKARGIKDATEIIFEMSKDERKDFYRTIAWGLNRPLFAVYRRVLRMYDDRNHVGKYTPEEIEKLKELRIKHGNDWATIGAALGRSASSVKDRCRLMKDTCNTGKWTEEEEKRLAEVVHELTSTEPGDIVTQGVSWAAVAERVGTRSEKQCRSKWLNYLNWKQSGGTEWTKEDEINLILRIAELDVADENDINWDLLAEGWSSVRSPQWLRSKWWTIKRQIANHKDVSFPVLIKGLKQLHENQKNNPTLLENKSGSGVPNSNTNSSVQHVQIRVARLEDNTAISSSPMAALQIPVQITHVSSADSPATVDSETITLNSGTLQTFEILPSFHLQPTGTPGTYLLQTSSSQGLPLTLTASPTVTLTAAAPASPEQIIVHALSPEHLLNTSDNVTVQCHTPRVIIQTVATEDITSSISQAELTVDSDIQSSDFPEPPDALEADTFPDEIHHPKMTVEPSFNDAHVSKFSDQNSTELMNSVMVRTEEEISDTDLKQEESPSDLASAYVTEGLESPTIEEQVDQTIDDETILIVPSPHGFIQASDVIDTESVLPLTTLTDPILQHHQEESNIIGSSLGSPVSEDSKDVEDLVNCH | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
|
|
||
* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 218 | Phosphorylation | YRRVLRMYDDRNHVG HHHHHHHHCCCCCCC | 14.30 | - | |
| 268 | Acetylation | KDRCRLMKDTCNTGK HHHHHHHHHCCCCCC | 55.25 | 18604619 | |
| 270 | Phosphorylation | RCRLMKDTCNTGKWT HHHHHHHCCCCCCCC | 11.35 | 28355574 | |
| 273 | Phosphorylation | LMKDTCNTGKWTEEE HHHHCCCCCCCCHHH | 42.14 | 28355574 | |
| 277 | Phosphorylation | TCNTGKWTEEEEKRL CCCCCCCCHHHHHHH | 36.68 | 28355574 | |
| 324 | Acetylation | SEKQCRSKWLNYLNW CHHHHHHHHHHHHCC | 36.03 | 25953088 | |
| 414 | Ubiquitination | KQLHENQKNNPTLLE HHHHHHHCCCCCCCC | 70.99 | - | |
| 640 | Phosphorylation | SKFSDQNSTELMNSV HHCCCCCHHHHHHHH | 20.02 | 27251275 | |
| 641 | Phosphorylation | KFSDQNSTELMNSVM HCCCCCHHHHHHHHE | 40.46 | 27251275 | |
| 656 | Phosphorylation | VRTEEEISDTDLKQE EECHHHHCCCCCCCC | 37.42 | 29255136 | |
| 658 | Phosphorylation | TEEEISDTDLKQEES CHHHHCCCCCCCCCC | 36.12 | 29255136 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of DMTF1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of DMTF1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of DMTF1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| P53_HUMAN | TP53 | physical | 22331460 | |
| SRA1_HUMAN | SRA1 | physical | 20398657 |
| Kegg Drug | ||||||
|---|---|---|---|---|---|---|
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
loading...
