EGR2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EGR2_HUMAN
• UniProt AC: P11161
• Protein Name: E3 SUMO-protein ligase EGR2
• Gene Name: EGR2
• Organism: Homo sapiens (Human).
• Sequence Length: 476
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4.; E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity..
• Protein Sequence: MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
70	Phosphorylation	DMTGEKRSLDLPYPS ECCCCEEECCCCCCC	36.98	22817900
70	O-linked_Glycosylation	DMTGEKRSLDLPYPS ECCCCEEECCCCCCC	36.98	29351928
75	Phosphorylation	KRSLDLPYPSSFAPV EEECCCCCCCCCCCC	24.04	22461510
77	Phosphorylation	SLDLPYPSSFAPVSA ECCCCCCCCCCCCCC	32.04	22461510
78	O-linked_Glycosylation	LDLPYPSSFAPVSAP CCCCCCCCCCCCCCC	22.41	29351928
78	Phosphorylation	LDLPYPSSFAPVSAP CCCCCCCCCCCCCCC	22.41	19690332
83	O-linked_Glycosylation	PSSFAPVSAPRNQTF CCCCCCCCCCCCCCE	31.34	29351928
89	O-linked_Glycosylation	VSAPRNQTFTYMGKF CCCCCCCCEEEEEEE	22.84	29351928
190	O-linked_Glycosylation	QDPSAFLSAATTSTS CCHHHHHHHCCCCCC	14.92	29351928
194	O-linked_Glycosylation	AFLSAATTSTSSSLA HHHHHCCCCCCCCCC	25.86	29351928
195	O-linked_Glycosylation	FLSAATTSTSSSLAY HHHHCCCCCCCCCCC	23.18	29351928
199	O-linked_Glycosylation	ATTSTSSSLAYPPPP CCCCCCCCCCCCCCC	19.45	29351928
247	Acetylation	GTAGPDRKPFPCPLD CCCCCCCCCCCCCCC	59.39	-
255	Phosphorylation	PFPCPLDTLRVPPPL CCCCCCCCCCCCCCC	24.93	22210691
257	Methylation	PCPLDTLRVPPPLTP CCCCCCCCCCCCCCC	40.77	-
263	Phosphorylation	LRVPPPLTPLSTIRN CCCCCCCCCHHHEEC	28.14	23312004
266	Phosphorylation	PPPLTPLSTIRNFTL CCCCCCHHHEECCCC	24.00	23312004
267	O-linked_Glycosylation	PPLTPLSTIRNFTLG CCCCCHHHEECCCCC	31.47	29351928
267	Phosphorylation	PPLTPLSTIRNFTLG CCCCCHHHEECCCCC	31.47	23312004
272	Phosphorylation	LSTIRNFTLGGPSAG HHHEECCCCCCCCCC	28.21	23532336
289	O-linked_Glycosylation	GPGASGGSEGPRLPG CCCCCCCCCCCCCCC	42.79	29351928
293	Methylation	SGGSEGPRLPGSSSA CCCCCCCCCCCCHHH	65.46	-
299	O-linked_Glycosylation	PRLPGSSSAAAAAAA CCCCCCHHHHHHHHH	24.51	29351928
380	Phosphorylation	RICMRNFSRSDHLTT EEECCCCCCCCCEEE	34.13	22817900
382	O-linked_Glycosylation	CMRNFSRSDHLTTHI ECCCCCCCCCEEEEE	28.34	29351928
387	O-linked_Glycosylation	SRSDHLTTHIRTHTG CCCCCEEEEEEECCC	22.97	29351928
391	Phosphorylation	HLTTHIRTHTGEKPF CEEEEEEECCCCCCC	24.16	-
393	Phosphorylation	TTHIRTHTGEKPFAC EEEEEECCCCCCCCC	46.56	8662759

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	WWP2	O00308	PMID:19651900

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
247	K	Acetylation	Acetylated at Lys-247.	-

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EGR2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HCFC1_HUMAN	HCFC1	physical	14532282
PPA5_HUMAN	ACP5	physical	16169070
MED31_HUMAN	MED31	physical	16169070
UBC9_HUMAN	UBE2I	physical	21836637
NAB2_HUMAN	NAB2	physical	21836637
DTX1_HUMAN	DTX1	physical	19592273
SRA1_HUMAN	SRA1	physical	20398657
JUPI2_HUMAN	HN1L	physical	21988832
NDUS2_HUMAN	NDUFS2	physical	21988832
RB15B_HUMAN	RBM15B	physical	21988832
RIMKB_HUMAN	RIMKLB	physical	21988832
RL7L_HUMAN	RPL7L1	physical	21988832

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• 605253: Neuropathy, congenital hypomyelinating or amyelinating (CHN)
• 607678: Charcot-Marie-Tooth disease 1D (CMT1D)
• 145900: Dejerine-Sottas syndrome (DSS)
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.