KLF12_HUMAN - dbPTM
KLF12_HUMAN - PTM Information in dbPTM
Basic Information of Protein
UniProt ID KLF12_HUMAN
UniProt AC Q9Y4X4
Protein Name Krueppel-like factor 12
Gene Name KLF12
Organism Homo sapiens (Human).
Sequence Length 402
Subcellular Localization Nucleus.
Protein Description Confers strong transcriptional repression to the AP-2-alpha gene. Binds to a regulatory element (A32) in the AP-2-alpha gene promoter..
Protein Sequence MNIHMKRKTIKNINTFENRMLMLDGMPAVRVKTELLESEQGSPNVHNYPDMEAVPLLLNNVKGEPPEDSLSVDHFQTQTEPVDLSINKARTSPTAVSSSPVSMTASASSPSSTSTSSSSSSRLASSPTVITSVSSASSSSTVLTPGPLVASASGVGGQQFLHIIHPVPPSSPMNLQSNKLSHVHRIPVVVQSVPVVYTAVRSPGNVNNTIVVPLLEDGRGHGKAQMDPRGLSPRQSKSDSDDDDLPNVTLDSVNETGSTALSIARAVQEVHPSPVSRVRGNRMNNQKFPCSISPFSIESTRRQRRSESPDSRKRRIHRCDFEGCNKVYTKSSHLKAHRRTHTGEKPYKCTWEGCTWKFARSDELTRHYRKHTGVKPFKCADCDRSFSRSDHLALHRRRHMLV
Overview of Protein Modification Sites with Functional and Structural Information
Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations Modification Substrate Peptides
&
Secondary Structure		 ASA (%) Reference Orthologous
Protein Cluster
15PhosphorylationKTIKNINTFENRMLM
CCCCCCCCCCCHHHH		28.64-
33PhosphorylationMPAVRVKTELLESEQ
CCEEEEEHHHHHCCC		29.0722199227
38PhosphorylationVKTELLESEQGSPNV
EEHHHHHCCCCCCCC		34.8822199227
42PhosphorylationLLESEQGSPNVHNYP
HHHCCCCCCCCCCCC		17.0022199227
48PhosphorylationGSPNVHNYPDMEAVP
CCCCCCCCCCHHHHH		5.9227080861
69PhosphorylationKGEPPEDSLSVDHFQ
CCCCCCCCCCCCCCC		22.3830576142
71PhosphorylationEPPEDSLSVDHFQTQ
CCCCCCCCCCCCCCC		29.4726714015
85PhosphorylationQTEPVDLSINKARTS
CCCCCCCEEECCCCC		21.4726074081
91PhosphorylationLSINKARTSPTAVSS
CEEECCCCCCCCCCC		43.8730576142
92PhosphorylationSINKARTSPTAVSSS
EEECCCCCCCCCCCC		18.0730576142
94PhosphorylationNKARTSPTAVSSSPV
ECCCCCCCCCCCCCC		39.1830576142
97PhosphorylationRTSPTAVSSSPVSMT
CCCCCCCCCCCCEEE		23.7230576142
98PhosphorylationTSPTAVSSSPVSMTA
CCCCCCCCCCCEEEE		31.8730576142
99PhosphorylationSPTAVSSSPVSMTAS
CCCCCCCCCCEEEEE		23.0930576142
102PhosphorylationAVSSSPVSMTASASS
CCCCCCCEEEEECCC		17.5030576142
104PhosphorylationSSSPVSMTASASSPS
CCCCCEEEEECCCCC		15.2330576142
106PhosphorylationSPVSMTASASSPSST
CCCEEEEECCCCCCC		21.3723090842
108PhosphorylationVSMTASASSPSSTST
CEEEEECCCCCCCCC		40.0430576142
109PhosphorylationSMTASASSPSSTSTS
EEEEECCCCCCCCCC		28.6330576142
111PhosphorylationTASASSPSSTSTSSS
EEECCCCCCCCCCCC		48.4722199227
112PhosphorylationASASSPSSTSTSSSS
EECCCCCCCCCCCCC		29.7530576142
113PhosphorylationSASSPSSTSTSSSSS
ECCCCCCCCCCCCCC		40.1227732954
114PhosphorylationASSPSSTSTSSSSSS
CCCCCCCCCCCCCCH		28.3923090842
115PhosphorylationSSPSSTSTSSSSSSR
CCCCCCCCCCCCCHH		32.4923090842
116PhosphorylationSPSSTSTSSSSSSRL
CCCCCCCCCCCCHHH		28.1727732954
117PhosphorylationPSSTSTSSSSSSRLA
CCCCCCCCCCCHHHC		34.0423090842
118PhosphorylationSSTSTSSSSSSRLAS
CCCCCCCCCCHHHCC		33.7227732954
119PhosphorylationSTSTSSSSSSRLASS
CCCCCCCCCHHHCCC		33.9923090842
120PhosphorylationTSTSSSSSSRLASSP
CCCCCCCCHHHCCCC		22.7923090842
121PhosphorylationSTSSSSSSRLASSPT
CCCCCCCHHHCCCCE		33.0127732954
192PhosphorylationRIPVVVQSVPVVYTA
CCCEEEECCCEEEEE		19.4428796482
197PhosphorylationVQSVPVVYTAVRSPG
EECCCEEEEEECCCC		6.8228796482
198PhosphorylationQSVPVVYTAVRSPGN
ECCCEEEEEECCCCC		13.6826074081
202PhosphorylationVVYTAVRSPGNVNNT
EEEEEECCCCCCCCE		30.4723401153
209PhosphorylationSPGNVNNTIVVPLLE
CCCCCCCEEEEEEEC		15.2230266825
232PhosphorylationQMDPRGLSPRQSKSD
CCCCCCCCCCCCCCC		22.3620873877
236PhosphorylationRGLSPRQSKSDSDDD
CCCCCCCCCCCCCCC		35.0922496350
238PhosphorylationLSPRQSKSDSDDDDL
CCCCCCCCCCCCCCC		47.8224275569
240PhosphorylationPRQSKSDSDDDDLPN
CCCCCCCCCCCCCCC		50.4522496350
249PhosphorylationDDDLPNVTLDSVNET
CCCCCCCCHHCCCCC		31.3321406692
252PhosphorylationLPNVTLDSVNETGST
CCCCCHHCCCCCCHH		29.9221406692
256PhosphorylationTLDSVNETGSTALSI
CHHCCCCCCHHHHHH		31.0921406692
258PhosphorylationDSVNETGSTALSIAR
HCCCCCCHHHHHHHH		20.2321406692
259PhosphorylationSVNETGSTALSIARA
CCCCCCHHHHHHHHH		32.7221406692
262PhosphorylationETGSTALSIARAVQE
CCCHHHHHHHHHHHH		16.2521406692
273PhosphorylationAVQEVHPSPVSRVRG
HHHHHCCCCCHHCCC		24.0525159151
276PhosphorylationEVHPSPVSRVRGNRM
HHCCCCCHHCCCCCC		28.5730576142
291PhosphorylationNNQKFPCSISPFSIE
CCCCCCCCCCCCCHH		26.7525850435
293PhosphorylationQKFPCSISPFSIEST
CCCCCCCCCCCHHHH		12.0025850435
296PhosphorylationPCSISPFSIESTRRQ
CCCCCCCCHHHHHHH		28.9122199227
299PhosphorylationISPFSIESTRRQRRS
CCCCCHHHHHHHHHC		26.0828122231
300PhosphorylationSPFSIESTRRQRRSE
CCCCHHHHHHHHHCC		19.6522199227
306PhosphorylationSTRRQRRSESPDSRK
HHHHHHHCCCCCHHH		44.6129496963
308PhosphorylationRRQRRSESPDSRKRR
HHHHHCCCCCHHHHH		34.9429496963
313MethylationSESPDSRKRRIHRCD
CCCCCHHHHHHHCCC		50.4018438403
340PhosphorylationHLKAHRRTHTGEKPY
HHHHCCCCCCCCCCC		24.6028348404
342PhosphorylationKAHRRTHTGEKPYKC
HHCCCCCCCCCCCEE		46.5626270265
345UbiquitinationRRTHTGEKPYKCTWE
CCCCCCCCCCEECCC		55.80-
372PhosphorylationTRHYRKHTGVKPFKC
HHHHHHHCCCCCCCC		46.8628555341
387PhosphorylationADCDRSFSRSDHLAL
CCCCCCCCHHHHHHH		31.9217081983
Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)
Modified Location Modified Residue Modification Type of Upstream Proteins Gene Name of Upstream Proteins UniProt AC of Upstream Proteins Sources

Oops, there are no upstream regulatory protein records of KLF12_HUMAN !!
Functions of PTM Sites
Modified Location Modified Residue Modification Function Reference

Oops, there are no descriptions of PTM sites of KLF12_HUMAN !!
Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location Modification Variant Position
(Distance <= 10) 		Residue Change SAP Related Disease Reference

Oops, there are no SNP-PTM records of KLF12_HUMAN !!
Protein-Protein Interaction
Interacting Protein Gene Name Interaction Type PPI Reference Domain-Domain Interactions
A4_HUMANAPPphysical
21832049
THAP1_HUMANTHAP1physical
25416956
Drug and Disease Associations
Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.
Regulatory Network of KLF12_HUMAN

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Related Literatures of Post-Translational Modification
Methylation
ReferencePubMed
"Protein lysine methyltransferase G9a acts on non-histone targets.";
Rathert P., Dhayalan A., Murakami M., Zhang X., Tamas R.,Jurkowska R., Komatsu Y., Shinkai Y., Cheng X., Jeltsch A.;
Nat. Chem. Biol. 4:344-346(2008).
Cited for: METHYLATION AT LYS-313.
Phosphorylation
ReferencePubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions.";
Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.;
Sci. Signal. 2:RA46-RA46(2009).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-202, AND MASSSPECTROMETRY.

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