HXC11_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: HXC11_HUMAN
• UniProt AC: O43248
• Protein Name: Homeobox protein Hox-C11
• Gene Name: HOXC11
• Organism: Homo sapiens (Human).
• Sequence Length: 304
• Subcellular Localization: Nucleus.
• Protein Description: Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. Binds to a promoter element of the lactase-phlorizin hydrolase gene..
• Protein Sequence: MFNSVNLGNFCSPSRKERGADFGERGSCASNLYLPSCTYYMPEFSTVSSFLPQAPSRQISYPYSAQVPPVREVSYGLEPSGKWHHRNSYSSCYAAADELMHRECLPPSTVTEILMKNEGSYGGHHHPSAPHATPAGFYSSVNKNSVLPQAFDRFFDNAYCGGGDPPAEPPCSGKGEAKGEPEAPPASGLASRAEAGAEAEAEEENTNPSSSGSAHSVAKEPAKGAAPNAPRTRKKRCPYSKFQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQNRRMKEKKLSRDRLQYFSGNPLL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
12	Phosphorylation	VNLGNFCSPSRKERG CCCCCCCCCCHHHCC	23.05	20068231
14	Phosphorylation	LGNFCSPSRKERGAD CCCCCCCCHHHCCCC	39.42	20068231
60	Phosphorylation	QAPSRQISYPYSAQV CCCCCCCCCCCCCCC	16.24	-
74	Phosphorylation	VPPVREVSYGLEPSG CCCCEEEECCCCCCC	14.55	21815630
82	Sumoylation	YGLEPSGKWHHRNSY CCCCCCCCCCCCCCH	47.92	28112733
88	Phosphorylation	GKWHHRNSYSSCYAA CCCCCCCCHHHHHHH	26.75	25159151
89	Phosphorylation	KWHHRNSYSSCYAAA CCCCCCCHHHHHHHH	14.25	27251275
90	Phosphorylation	WHHRNSYSSCYAAAD CCCCCCHHHHHHHHH	17.47	28348404
116	Sumoylation	TVTEILMKNEGSYGG HHHHHHCCCCCCCCC	48.69	28112733
120	Phosphorylation	ILMKNEGSYGGHHHP HHCCCCCCCCCCCCC	17.90	26434552
128	Phosphorylation	YGGHHHPSAPHATPA CCCCCCCCCCCCCCC	50.50	26434552
138	Phosphorylation	HATPAGFYSSVNKNS CCCCCCCCCCCCCCC	10.10	26434552
139	Phosphorylation	ATPAGFYSSVNKNSV CCCCCCCCCCCCCCC	26.08	26434552
143	Ubiquitination	GFYSSVNKNSVLPQA CCCCCCCCCCCCCHH	48.74	29967540
174	Acetylation	AEPPCSGKGEAKGEP CCCCCCCCCCCCCCC	36.97	26051181
178	Ubiquitination	CSGKGEAKGEPEAPP CCCCCCCCCCCCCCC	60.55	29967540
178	Acetylation	CSGKGEAKGEPEAPP CCCCCCCCCCCCCCC	60.55	26051181
178	Sumoylation	CSGKGEAKGEPEAPP CCCCCCCCCCCCCCC	60.55	28112733
178	Sumoylation	CSGKGEAKGEPEAPP CCCCCCCCCCCCCCC	60.55	-
206	Phosphorylation	AEAEEENTNPSSSGS HHHHHHHCCCCCCCC	52.35	25159151
211	Phosphorylation	ENTNPSSSGSAHSVA HHCCCCCCCCCCHHC	40.90	25627689
213	Phosphorylation	TNPSSSGSAHSVAKE CCCCCCCCCCHHCCC	25.42	25627689
219	Acetylation	GSAHSVAKEPAKGAA CCCCHHCCCCCCCCC	63.17	26051181
223	Ubiquitination	SVAKEPAKGAAPNAP HHCCCCCCCCCCCCC	60.85	29967540
223	Acetylation	SVAKEPAKGAAPNAP HHCCCCCCCCCCCCC	60.85	26051181
241	Acetylation	KKRCPYSKFQIRELE CCCCCCCCHHHHHHH	35.13	26051181
272	Phosphorylation	LSRMLNLTDRQVKIW HHHHHCCCHHHHHHH	28.23	18767875

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of HXC11_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of HXC11_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of HXC11_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
IRF4_HUMAN	IRF4	physical	20211142
SMAD3_HUMAN	SMAD3	physical	20211142
MEIS1_HUMAN	MEIS1	physical	20211142
SP1_HUMAN	SP1	physical	20211142
STAT3_HUMAN	STAT3	physical	20211142
HDAC5_HUMAN	HDAC5	physical	20211142
TF2AY_HUMAN	GTF2A1L	physical	20211142
TBX21_HUMAN	TBX21	physical	20211142
SOX8_HUMAN	SOX8	physical	20211142

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.