| UniProt ID | MEIS1_HUMAN | |
|---|---|---|
| UniProt AC | O00470 | |
| Protein Name | Homeobox protein Meis1 | |
| Gene Name | MEIS1 | |
| Organism | Homo sapiens (Human). | |
| Sequence Length | 390 | |
| Subcellular Localization | Nucleus . | |
| Protein Description | Acts as a transcriptional regulator of PAX6. Acts as a transcriptional activator of PF4 in complex with PBX1 or PBX2. Required for hematopoiesis, megakaryocyte lineage development and vascular patterning. May function as a cofactor for HOXA7 and HOXA9 in the induction of myeloid leukemias.. | |
| Protein Sequence | MAQRYDDLPHYGGMDGVGIPSTMYGDPHAARSMQPVHHLNHGPPLHSHQYPHTAHTNAMAPSMGSSVNDALKRDKDAIYGHPLFPLLALIFEKCELATCTPREPGVAGGDVCSSESFNEDIAVFAKQIRAEKPLFSSNPELDNLMIQAIQVLRFHLLELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSKSDSEDITRSANLTDQPSWNRDHDDTASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATNIMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRAVSQGTPYNPDGQPMGGFVMDGQQHMGIRAPGPMSGMGMNMGMEGQWHYM | |
| Overview of Protein Modification Sites with Functional and Structural Information | ||
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* ASA = Accessible Surface Area
| Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
|---|---|---|---|---|---|
| 3 (in isoform 2) | Phosphorylation | - | 43.07 | 24043423 | |
| 9 (in isoform 2) | Phosphorylation | - | 26.16 | 24043423 | |
| 19 (in isoform 2) | Phosphorylation | - | 1.95 | 24043423 | |
| 20 (in isoform 2) | Phosphorylation | - | 20.16 | 24043423 | |
| 22 (in isoform 2) | Phosphorylation | - | 14.73 | 24043423 | |
| 72 | Sumoylation | SSVNDALKRDKDAIY CHHHHHHHHCHHHHH | 61.34 | - | |
| 72 | Sumoylation | SSVNDALKRDKDAIY CHHHHHHHHCHHHHH | 61.34 | 17000644 | |
| 136 | Phosphorylation | RAEKPLFSSNPELDN HCCCCCCCCCHHHHH | 36.57 | 27732954 | |
| 137 | Phosphorylation | AEKPLFSSNPELDNL CCCCCCCCCHHHHHH | 49.41 | 27732954 | |
| 178 | Ubiquitination | HRYISCLKGKMPIDL HHHHHHHCCCCCCEE | 61.89 | 29967540 | |
| 194 | Phosphorylation | IDDREGGSKSDSEDI EECCCCCCCCCHHHH | 39.58 | 23401153 | |
| 196 | Phosphorylation | DREGGSKSDSEDITR CCCCCCCCCHHHHHH | 48.33 | 23401153 | |
| 198 | Phosphorylation | EGGSKSDSEDITRSA CCCCCCCHHHHHHHC | 44.23 | 23401153 | |
| 202 | Phosphorylation | KSDSEDITRSANLTD CCCHHHHHHHCCCCC | 30.78 | 22167270 | |
| 204 | Phosphorylation | DSEDITRSANLTDQP CHHHHHHHCCCCCCC | 16.92 | 28555341 | |
| 212 | Phosphorylation | ANLTDQPSWNRDHDD CCCCCCCCCCCCCCC | 31.20 | 27732954 | |
| 220 | Phosphorylation | WNRDHDDTASTRSGG CCCCCCCCCCCCCCC | 28.68 | 28555341 | |
| 222 | Phosphorylation | RDHDDTASTRSGGTP CCCCCCCCCCCCCCC | 26.84 | 25849741 | |
| 228 | Phosphorylation | ASTRSGGTPGPSSGG CCCCCCCCCCCCCCC | 28.70 | 30377224 | |
| 232 | Phosphorylation | SGGTPGPSSGGHTSH CCCCCCCCCCCCCCC | 47.75 | 30377224 | |
| 233 | Phosphorylation | GGTPGPSSGGHTSHS CCCCCCCCCCCCCCC | 52.51 | 30377224 | |
| 237 | Phosphorylation | GPSSGGHTSHSGDNS CCCCCCCCCCCCCCC | 31.26 | 30377224 | |
| 238 | Phosphorylation | PSSGGHTSHSGDNSS CCCCCCCCCCCCCCC | 15.24 | 30377224 | |
| 240 | Phosphorylation | SGGHTSHSGDNSSEQ CCCCCCCCCCCCCCC | 47.84 | 30377224 | |
| 244 | Phosphorylation | TSHSGDNSSEQGDGL CCCCCCCCCCCCCCC | 39.74 | 30377224 | |
| 245 | Phosphorylation | SHSGDNSSEQGDGLD CCCCCCCCCCCCCCC | 39.95 | 30377224 | |
| 257 | Phosphorylation | GLDNSVASPSTGDDD CCCCCCCCCCCCCCC | 19.75 | 30377224 | |
| 259 | Phosphorylation | DNSVASPSTGDDDDP CCCCCCCCCCCCCCC | 42.39 | 30377224 | |
| 260 | Phosphorylation | NSVASPSTGDDDDPD CCCCCCCCCCCCCCC | 48.27 | 30377224 | |
| 343 | Phosphorylation | DQSNRAVSQGTPYNP CCCCCCHHCCCCCCC | 23.16 | 22210691 | |
| 346 | Phosphorylation | NRAVSQGTPYNPDGQ CCCHHCCCCCCCCCC | 18.24 | 22210691 |
| Modified Location | Modified Residue | Modification | Type of Upstream Proteins | Gene Name of Upstream Proteins | UniProt AC of Upstream Proteins | Sources |
|---|---|---|---|---|---|---|
Oops, there are no upstream regulatory protein records of MEIS1_HUMAN !! | ||||||
| Modified Location | Modified Residue | Modification | Function | Reference | ||
|---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of MEIS1_HUMAN !! | ||||||
* Distance = the distance between SAP position and PTM sites.
| Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
|---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of MEIS1_HUMAN !! | ||||||
| Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
|---|---|---|---|---|
| HXA9_HUMAN | HOXA9 | physical | 9343407 | |
| PBX1_HUMAN | PBX1 | physical | 10082572 | |
| HXA9_HUMAN | HOXA9 | physical | 10082572 | |
| HXD9_HUMAN | HOXD9 | physical | 10523646 | |
| PBX1_HUMAN | PBX1 | physical | 20237320 | |
| CREB1_HUMAN | CREB1 | physical | 20541704 | |
| CRTC1_HUMAN | CRTC1 | physical | 20541704 | |
| CBP_HUMAN | CREBBP | physical | 20541704 | |
| ETS1_HUMAN | ETS1 | physical | 18692240 | |
| TM10B_HUMAN | TRMT10B | physical | 21988832 |
| Kegg Disease | ||||||
|---|---|---|---|---|---|---|
| There are no disease associations of PTM sites. | ||||||
| OMIM Disease | ||||||
| 612853 | Restless legs syndrome 7 (RLS7) | |||||
| Kegg Drug | ||||||
| There are no disease associations of PTM sites. | ||||||
| DrugBank | ||||||
| There are no disease associations of PTM sites. | ||||||
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