TM10B_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: TM10B_HUMAN
• UniProt AC: Q6PF06
• Protein Name: tRNA methyltransferase 10 homolog B
• Gene Name: TRMT10B
• Organism: Homo sapiens (Human).
• Sequence Length: 316
• Protein Description: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs. [PubMed: 23042678 Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A9) in tRNAs]
• Protein Sequence: MDWKLEGSTQKVESPVLQGQEGILEETGEDGLPEGFQLLQIDAEGECQEGEILATGSTAWCSKNVQRKQRHWEKIVAAKKSKRKQEKERRKANRAENPGICPQHSKRFLRALTKDKLLEAKHSGPRLCIDLSMTHYMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEECVRMNDGFSSYLLDITEEDCFSLFPLETLVYLTPDSEHALEDVDLNKVYILGGLVDESIQKKVTFQKAREYSVKTARLPIQEYMVRNQNGKNYHSEILAINQVFDILSTYLETHNWPEALKKGVSSGKGYILRNSVE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
113	Phosphorylation	KRFLRALTKDKLLEA HHHHHHHHHHHHHHC		24719451
143	Phosphorylation	YMSKKELSRLAGQIR CCCHHHHHHHHHHHH		-
143	O-linked_Glycosylation	YMSKKELSRLAGQIR CCCHHHHHHHHHHHH		30379171
304	Phosphorylation	EALKKGVSSGKGYIL HHHHHCHHCCCCEEC		21955146
305	Phosphorylation	ALKKGVSSGKGYILR HHHHCHHCCCCEECC		21955146
309	Phosphorylation	GVSSGKGYILRNSVE CHHCCCCEECCCCCC		21955146

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of TM10B_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of TM10B_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of TM10B_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RL26L_HUMAN	RPL26L1	physical	26186194
RT09_HUMAN	MRPS9	physical	26186194
RT26_HUMAN	MRPS26	physical	26186194
PTCD3_HUMAN	PTCD3	physical	26186194
RT23_HUMAN	MRPS23	physical	26186194
RT27_HUMAN	MRPS27	physical	26186194
RT18B_HUMAN	MRPS18B	physical	26186194
RT10_HUMAN	MRPS10	physical	26186194
RT34_HUMAN	MRPS34	physical	26186194
RT29_HUMAN	DAP3	physical	26186194
NOA1_HUMAN	NOA1	physical	26186194
RT28_HUMAN	MRPS28	physical	26186194
RT31_HUMAN	MRPS31	physical	26186194
RT18C_HUMAN	MRPS18C	physical	26186194
RT05_HUMAN	MRPS5	physical	26186194
RT07_HUMAN	MRPS7	physical	26186194
RT22_HUMAN	MRPS22	physical	26186194
RT15_HUMAN	MRPS15	physical	26186194
RT35_HUMAN	MRPS35	physical	26186194
RT25_HUMAN	MRPS25	physical	26186194
KBTB6_HUMAN	KBTBD6	physical	26186194
RT02_HUMAN	MRPS2	physical	26186194
RT33_HUMAN	MRPS33	physical	26186194
RT11_HUMAN	MRPS11	physical	26186194
RT24_HUMAN	MRPS24	physical	26186194
RT14_HUMAN	MRPS14	physical	26186194
RT16_HUMAN	MRPS16	physical	26186194
PTX3_HUMAN	PTX3	physical	26186194
RT21_HUMAN	MRPS21	physical	26186194
TIGD5_HUMAN	TIGD5	physical	26186194
NOA1_HUMAN	NOA1	physical	28514442
RT33_HUMAN	MRPS33	physical	28514442
RT35_HUMAN	MRPS35	physical	28514442
PTX3_HUMAN	PTX3	physical	28514442
RT05_HUMAN	MRPS5	physical	28514442
RT18C_HUMAN	MRPS18C	physical	28514442
PTCD3_HUMAN	PTCD3	physical	28514442
RT09_HUMAN	MRPS9	physical	28514442
RT07_HUMAN	MRPS7	physical	28514442
RT29_HUMAN	DAP3	physical	28514442
RT10_HUMAN	MRPS10	physical	28514442
RT23_HUMAN	MRPS23	physical	28514442
RT21_HUMAN	MRPS21	physical	28514442
RT31_HUMAN	MRPS31	physical	28514442
RT24_HUMAN	MRPS24	physical	28514442
RT11_HUMAN	MRPS11	physical	28514442
RT15_HUMAN	MRPS15	physical	28514442
RL26L_HUMAN	RPL26L1	physical	28514442
RT02_HUMAN	MRPS2	physical	28514442
RT16_HUMAN	MRPS16	physical	28514442
RT25_HUMAN	MRPS25	physical	28514442
RT27_HUMAN	MRPS27	physical	28514442
RT26_HUMAN	MRPS26	physical	28514442
RT14_HUMAN	MRPS14	physical	28514442
RT34_HUMAN	MRPS34	physical	28514442
RT18B_HUMAN	MRPS18B	physical	28514442
RT28_HUMAN	MRPS28	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.