EGR4_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: EGR4_HUMAN
• UniProt AC: Q05215
• Protein Name: Early growth response protein 4
• Gene Name: EGR4
• Organism: Homo sapiens (Human).
• Sequence Length: 589
• Subcellular Localization: Nucleus .
• Protein Description: Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCGGGGGCG-3' (GSG). Activates the transcription of target genes whose products are required for mitogenesis and differentiation (By similarity)..
• Protein Sequence: MAVARGVGSPEPAPPQLYKWGGCGLGEPGSALERRGAAARGRCGRARAPRLPDSFPRGECPKPGARAPRSVRCGEPLPPASPPPARPQAQRARPRAPHSRRRAMLHLSEFSEPDALLVKSTEGCCAEPSAELPRLPARDAPAATGYPGAGDFLSWALNSCGASGDLADSCFLEGPAPTPPPGLSYSGSFFIQAVPEHPHDPEALFNLMSGILGLAPFPGPEAAASRSPLDAPFPAGSDALLPGPPDLYSPDLGAAPFPEAFWEASPCAGAPSQCLYEPQLSPPDVKPGLRAPPASPALDAVSAFKGPYAPWELLSVGAPGNCGSQGDYQAAPEARFPVIGTKIEDLLSISCPAELPAVPANRLYPSGAYDAFPLAPGDLGEGAEGLPGLLTPPSGEGGSSGDGGEFLASTQPQLSPLGLRSAAAADFPKPLVADIPGSSGVAAPPVPPPPPTPFPQAKARRKGRRGGKCSTRCFCPRPHAKAFACPVESCVRSFARSDELNRHLRIHTGHKPFQCRICLRNFSRSDHLTTHVRTHTGEKPFACDVCGRRFARSDEKKRHSKVHLKQKARAEERLKGLGFYSLGLSFASL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
81	Phosphorylation	GEPLPPASPPPARPQ CCCCCCCCCCCCCCH	24.14	27732954
315	Phosphorylation	YAPWELLSVGAPGNC CCCCEEEECCCCCCC	23.56	22210691
328	Phosphorylation	NCGSQGDYQAAPEAR CCCCCCCCCCCCCCC	6.56	22210691
341	Phosphorylation	ARFPVIGTKIEDLLS CCCCCCCCCHHHHHC	22.23	22210691
523	Phosphorylation	RICLRNFSRSDHLTT EEEECCCCCCCCEEE		26074081
525	Phosphorylation	CLRNFSRSDHLTTHV EECCCCCCCCEEEEE		26074081
529	Phosphorylation	FSRSDHLTTHVRTHT CCCCCCEEEEEEECC		26074081
530	Phosphorylation	SRSDHLTTHVRTHTG CCCCCEEEEEEECCC		26074081
534	Phosphorylation	HLTTHVRTHTGEKPF CEEEEEEECCCCCCE		-
536	Phosphorylation	TTHVRTHTGEKPFAC EEEEEECCCCCCEEC		-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of EGR4_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of EGR4_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of EGR4_HUMAN !!

Protein-Protein Interaction

Oops, there are no PPI records of EGR4_HUMAN !!

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.