dbPTM

REPS1_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	REPS1_HUMAN
UniProt AC	Q96D71
Protein Name	RalBP1-associated Eps domain-containing protein 1
Gene Name	REPS1
Organism	Homo sapiens (Human).
Sequence Length	796
Subcellular Localization	Membrane, clathrin-coated pit . Colocalize with ITSN1 at the plasma membrane in structures that are most probably clathrin-coated pits.
Protein Description	May coordinate the cellular actions of activated EGF receptors and Ral-GTPases..
Protein Sequence	MEGLTLSDAEQKYYSDLFSYCDIESTKKVVVNGRVLELFRAAQLPNDVVLQIMELCGATRLGYFGRSQFYIALKLVAVAQSGFPLRVESINTVKDLPLPRFVASKNEQESRHAASYSSDSENQGSYSGVIPPPPGRGQVKKGSVSHDTVQPRTSADAQEPASPVVSPQQSPPTSPHTWRKHSRHPSGGNSERPLAGPGPFWSPFGEAQSGSSAGDAVWSGHSPPPPQENWVSFADTPPTSTLLTMHPASVQDQTTVRTVASATTAIEIRRQSSSYDDPWKITDEQRQYYVNQFKTIQPDLNGFIPGSAAKEFFTKSKLPILELSHIWELSDFDKDGALTLDEFCAAFHLVVARKNGYDLPEKLPESLMPKLIDLEDSADVGDQPGEVGYSGSPAEAPPSKSPSMPSLNQTWPELNQSSEQWETFSERSSSSQTLTQFDSNIAPADPDTAIVHPVPIRMTPSKIHMQEMELKRTGSDHTNPTSPLLVKPSDLLEENKINSSVKFASGNTVADGYSSSDSFTSDPEQIGSNVTRQRSHSGTSPDNTAPPPPPPRPQPSHSRSSSLDMNRTFTVTTGQQQAGVVAHPPAVPPRPQPSQAPGPAVHRPVDADGLITHTSTSPQQIPEQPNFADFSQFEVFAASNVNDEQDDEAEKHPEVLPAEKASDPASSLRVAKTDSKTEEKTAASAPANVSKGTTPLAPPPKPVRRRLKSEDELRPEVDEHTQKTGVLAAVLASQPSIPRSVGKDKKAIQASIRRNKETNTVLARLNSELQQQLKDVLEERISLEVQLEQLRPFSHL

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
5	Phosphorylation	---MEGLTLSDAEQK ---CCCCCCCHHHHH	34.76	23401153
27	Ubiquitination	YCDIESTKKVVVNGR HCCCCCCCEEEECCH	53.50	-
66	Phosphorylation	TRLGYFGRSQFYIAL CCCCCCCHHHHHHHH	19.86	18669648
81	Phosphorylation	KLVAVAQSGFPLRVE HHHHHHHHCCCCEEE	32.44	-
104	Phosphorylation	PLPRFVASKNEQESR CCCEEECCCCHHHHH	30.61	29496963
104 (in isoform 3)	Phosphorylation	-	30.61	27251275
110	Phosphorylation	ASKNEQESRHAASYS CCCCHHHHHHCCCCC	29.12	18669648
114	Phosphorylation	EQESRHAASYSSDSE HHHHHHCCCCCCCCC	11.68	18669648
115	Phosphorylation	QESRHAASYSSDSEN HHHHHCCCCCCCCCC	26.74	21945579
115 (in isoform 3)	Phosphorylation	-	26.74	27642862
116	Phosphorylation	ESRHAASYSSDSENQ HHHHCCCCCCCCCCC	13.89	21945579
116 (in isoform 3)	Phosphorylation	-	13.89	-
117	Phosphorylation	SRHAASYSSDSENQG HHHCCCCCCCCCCCC	25.77	21945579
117 (in isoform 3)	Phosphorylation	-	25.77	27642862
118	Phosphorylation	RHAASYSSDSENQGS HHCCCCCCCCCCCCC	36.60	23927012
118 (in isoform 3)	Phosphorylation	-	36.60	27642862
120	Phosphorylation	AASYSSDSENQGSYS CCCCCCCCCCCCCCC	40.16	21945579
120 (in isoform 3)	Phosphorylation	-	40.16	27642862
121	Phosphorylation	ASYSSDSENQGSYSG CCCCCCCCCCCCCCC	59.57	18669648
122	Phosphorylation	SYSSDSENQGSYSGV CCCCCCCCCCCCCCC	56.30	18669648
125	Phosphorylation	SDSENQGSYSGVIPP CCCCCCCCCCCCCCC	13.32	21945579
126	Phosphorylation	DSENQGSYSGVIPPP CCCCCCCCCCCCCCC	19.10	21945579
126 (in isoform 3)	Phosphorylation	-	19.10	27642862
127	Phosphorylation	SENQGSYSGVIPPPP CCCCCCCCCCCCCCC	28.42	21945579
143	Phosphorylation	RGQVKKGSVSHDTVQ CCCCCCCCCCCCCCC	29.35	29255136
143 (in isoform 3)	Phosphorylation	-	29.35	27251275
145	Phosphorylation	QVKKGSVSHDTVQPR CCCCCCCCCCCCCCC	19.83	23401153
148	Phosphorylation	KGSVSHDTVQPRTSA CCCCCCCCCCCCCCC	18.67	23927012
153	Phosphorylation	HDTVQPRTSADAQEP CCCCCCCCCCCCCCC	34.64	30278072
154	Phosphorylation	DTVQPRTSADAQEPA CCCCCCCCCCCCCCC	25.98	23927012
162	Phosphorylation	ADAQEPASPVVSPQQ CCCCCCCCCCCCCCC	29.01	23927012
162 (in isoform 3)	Phosphorylation	-	29.01	27251275
166	Phosphorylation	EPASPVVSPQQSPPT CCCCCCCCCCCCCCC	19.75	25159151
166 (in isoform 3)	Phosphorylation	-	19.75	27251275
170	Phosphorylation	PVVSPQQSPPTSPHT CCCCCCCCCCCCCCC	27.83	19664994
170 (in isoform 3)	Phosphorylation	-	27.83	27251275
173	Phosphorylation	SPQQSPPTSPHTWRK CCCCCCCCCCCCCCC	59.27	25159151
173 (in isoform 3)	Phosphorylation	-	59.27	27251275
174	Phosphorylation	PQQSPPTSPHTWRKH CCCCCCCCCCCCCCC	22.06	25159151
174 (in isoform 3)	Phosphorylation	-	22.06	-
177	Phosphorylation	SPPTSPHTWRKHSRH CCCCCCCCCCCCCCC	30.28	30266825
186	Phosphorylation	RKHSRHPSGGNSERP CCCCCCCCCCCCCCC	53.89	30242111
190	Phosphorylation	RHPSGGNSERPLAGP CCCCCCCCCCCCCCC	37.95	24275569
219	Phosphorylation	SAGDAVWSGHSPPPP CCCCCCCCCCCCCCC	21.74	26074081
220	Phosphorylation	AGDAVWSGHSPPPPQ CCCCCCCCCCCCCCC	15.02	18669648
221	Phosphorylation	GDAVWSGHSPPPPQE CCCCCCCCCCCCCCC	31.45	18669648
222	Phosphorylation	DAVWSGHSPPPPQEN CCCCCCCCCCCCCCC	42.50	26074081
223	Phosphorylation	AVWSGHSPPPPQENW CCCCCCCCCCCCCCC	39.48	18669648
236	Phosphorylation	NWVSFADTPPTSTLL CCEECCCCCCCCCEE	27.95	26074081
239	Phosphorylation	SFADTPPTSTLLTMH ECCCCCCCCCEEEEC	35.23	26074081
240	Phosphorylation	FADTPPTSTLLTMHP CCCCCCCCCEEEECC	23.88	26074081
255	Phosphorylation	ASVQDQTTVRTVASA CCCCCCCHHHHHHCC	11.45	18669648
258	O-linked_Glycosylation	QDQTTVRTVASATTA CCCCHHHHHHCCCCH	18.98	28411811
258	Phosphorylation	QDQTTVRTVASATTA CCCCHHHHHHCCCCH	18.98	27251275
261	O-linked_Glycosylation	TTVRTVASATTAIEI CHHHHHHCCCCHHHH	23.08	28411811
261	Phosphorylation	TTVRTVASATTAIEI CHHHHHHCCCCHHHH	23.08	27050516
261 (in isoform 3)	Phosphorylation	-	23.08	27251275
263	Phosphorylation	VRTVASATTAIEIRR HHHHHCCCCHHHHHH	17.79	23186163
264	Phosphorylation	RTVASATTAIEIRRQ HHHHCCCCHHHHHHC	25.92	23186163
272	Phosphorylation	AIEIRRQSSSYDDPW HHHHHHCCCCCCCCC	21.31	19664994
272 (in isoform 3)	Phosphorylation	-	21.31	27642862
273	Phosphorylation	IEIRRQSSSYDDPWK HHHHHCCCCCCCCCC	25.28	25159151
273 (in isoform 3)	Phosphorylation	-	25.28	27642862
274	Phosphorylation	EIRRQSSSYDDPWKI HHHHCCCCCCCCCCC	37.52	23927012
274 (in isoform 3)	Phosphorylation	-	37.52	27642862
275	Phosphorylation	IRRQSSSYDDPWKIT HHHCCCCCCCCCCCC	26.72	30266825
275 (in isoform 3)	Phosphorylation	-	26.72	27642862
282	Phosphorylation	YDDPWKITDEQRQYY CCCCCCCCHHHHHHH	29.74	23403867
288	Phosphorylation	ITDEQRQYYVNQFKT CCHHHHHHHHHCCCC	16.15	-
295	Phosphorylation	YYVNQFKTIQPDLNG HHHHCCCCCCCCCCC	26.57	26074081
307	Phosphorylation	LNGFIPGSAAKEFFT CCCCCCCHHHHHHHH	21.50	25159151
307 (in isoform 3)	Phosphorylation	-	21.50	27251275
357	Phosphorylation	VVARKNGYDLPEKLP HHHHHCCCCCCHHCC	24.57	20049867
377	Phosphorylation	KLIDLEDSADVGDQP HHCCCCCCCCCCCCC	19.59	25159151
389	Phosphorylation	DQPGEVGYSGSPAEA CCCCCCCCCCCCCCC	18.29	30278072
390	Phosphorylation	QPGEVGYSGSPAEAP CCCCCCCCCCCCCCC	27.19	19664994
390 (in isoform 3)	Phosphorylation	-	27.19	-
392	Phosphorylation	GEVGYSGSPAEAPPS CCCCCCCCCCCCCCC	18.26	28355574
392 (in isoform 3)	Phosphorylation	-	18.26	27251275
399	Phosphorylation	SPAEAPPSKSPSMPS CCCCCCCCCCCCCCC	44.71	25159151
401	Phosphorylation	AEAPPSKSPSMPSLN CCCCCCCCCCCCCHH	26.92	22496350
401 (in isoform 2)	Phosphorylation	-	26.92	26657352
401 (in isoform 4)	Phosphorylation	-	26.92	26657352
403	Phosphorylation	APPSKSPSMPSLNQT CCCCCCCCCCCHHHC	50.87	29507054
403 (in isoform 2)	Phosphorylation	-	50.87	26657352
403 (in isoform 4)	Phosphorylation	-	50.87	26657352
406	Phosphorylation	SKSPSMPSLNQTWPE CCCCCCCCHHHCCHH	31.17	26074081
406 (in isoform 2)	Phosphorylation	-	31.17	25850435
406 (in isoform 4)	Phosphorylation	-	31.17	25850435
410	Phosphorylation	SMPSLNQTWPELNQS CCCCHHHCCHHHHCC	41.75	26074081
410 (in isoform 2)	Phosphorylation	-	41.75	29978859
410 (in isoform 3)	Phosphorylation	-	41.75	27251275
410 (in isoform 4)	Phosphorylation	-	41.75	29978859
417	Phosphorylation	TWPELNQSSEQWETF CCHHHHCCHHHHHHH	34.47	27080861
417 (in isoform 2)	Phosphorylation	-	34.47	27732954
417 (in isoform 4)	Phosphorylation	-	34.47	27732954
418	Phosphorylation	WPELNQSSEQWETFS CHHHHCCHHHHHHHH	24.84	27080861
418 (in isoform 2)	Phosphorylation	-	24.84	27732954
418 (in isoform 4)	Phosphorylation	-	24.84	27732954
421	Phosphorylation	LNQSSEQWETFSERS HHCCHHHHHHHHHHC	11.53	27251275
421 (in isoform 2)	Phosphorylation	-	11.53	29978859
421 (in isoform 4)	Phosphorylation	-	11.53	29978859
428	Phosphorylation	WETFSERSSSSQTLT HHHHHHHCCCCCCEE	30.44	30278072
428 (in isoform 3)	Phosphorylation	-	30.44	24719451
429	Phosphorylation	ETFSERSSSSQTLTQ HHHHHHCCCCCCEEC	39.98	30278072
429 (in isoform 3)	Phosphorylation	-	39.98	27251275
430	Phosphorylation	TFSERSSSSQTLTQF HHHHHCCCCCCEECC	27.93	23401153
431	Phosphorylation	FSERSSSSQTLTQFD HHHHCCCCCCEECCC	29.18	30278072
432	Phosphorylation	SERSSSSQTLTQFDS HHHCCCCCCEECCCC	42.34	24719451
432 (in isoform 2)	Phosphorylation	-	42.34	28348404
432 (in isoform 4)	Phosphorylation	-	42.34	28348404
433	Phosphorylation	ERSSSSQTLTQFDSN HHCCCCCCEECCCCC	33.45	30278072
434 (in isoform 2)	Phosphorylation	-	2.48	28348404
434 (in isoform 4)	Phosphorylation	-	2.48	28348404
435	Phosphorylation	SSSSQTLTQFDSNIA CCCCCCEECCCCCCC	30.49	30278072
439	Phosphorylation	QTLTQFDSNIAPADP CCEECCCCCCCCCCC	31.27	23898821
446	Phosphorylation	SNIAPADPDTAIVHP CCCCCCCCCCCEEEC	42.85	24719451
448	Phosphorylation	IAPADPDTAIVHPVP CCCCCCCCCEEECCC	24.54	23898821
454	Phosphorylation	DTAIVHPVPIRMTPS CCCEEECCCCCCCCC	3.57	24719451
455	Phosphorylation	TAIVHPVPIRMTPSK CCEEECCCCCCCCCH	16.96	24719451
459	Phosphorylation	HPVPIRMTPSKIHMQ ECCCCCCCCCHHHCC	17.98	19664994
459 (in isoform 3)	Phosphorylation	-	17.98	27251275
461	Phosphorylation	VPIRMTPSKIHMQEM CCCCCCCCHHHCCEE	34.77	23898821
462	Acetylation	PIRMTPSKIHMQEME CCCCCCCHHHCCEEE	37.52	25953088
462	Ubiquitination	PIRMTPSKIHMQEME CCCCCCCHHHCCEEE	37.52	-
471	Methylation	HMQEMELKRTGSDHT HCCEEEEHHCCCCCC	34.31	115976509
473	Phosphorylation	QEMELKRTGSDHTNP CEEEEHHCCCCCCCC	39.18	30278072
475	Phosphorylation	MELKRTGSDHTNPTS EEEHHCCCCCCCCCC	26.13	23927012
475 (in isoform 3)	Phosphorylation	-	26.13	27251275
478	Phosphorylation	KRTGSDHTNPTSPLL HHCCCCCCCCCCCCE	48.13	23927012
478 (in isoform 3)	Phosphorylation	-	48.13	27251275
481	Phosphorylation	GSDHTNPTSPLLVKP CCCCCCCCCCCEECH	45.08	22167270
482	Phosphorylation	SDHTNPTSPLLVKPS CCCCCCCCCCEECHH	18.14	22167270
482 (in isoform 3)	Phosphorylation	-	18.14	27251275
487	Phosphorylation	PTSPLLVKPSDLLEE CCCCCEECHHHHHHH	38.48	27251275
488	Phosphorylation	TSPLLVKPSDLLEEN CCCCEECHHHHHHHC	26.12	24719451
489	Phosphorylation	SPLLVKPSDLLEENK CCCEECHHHHHHHCC	34.86	23927012
489 (in isoform 3)	Phosphorylation	-	34.86	-
494	Phosphorylation	KPSDLLEENKINSSV CHHHHHHHCCCCCCC	64.89	27251275
499	Phosphorylation	LEENKINSSVKFASG HHHCCCCCCCEECCC	39.73	23927012
500	Phosphorylation	EENKINSSVKFASGN HHCCCCCCCEECCCC	25.49	23927012
505	Phosphorylation	NSSVKFASGNTVADG CCCCEECCCCCCCCC	35.39	23090842
505 (in isoform 3)	Phosphorylation	-	35.39	22115753
508	Phosphorylation	VKFASGNTVADGYSS CEECCCCCCCCCCCC	22.16	28450419
508 (in isoform 3)	Phosphorylation	-	22.16	22115753
510	Phosphorylation	FASGNTVADGYSSSD ECCCCCCCCCCCCCC	11.50	24719451
512 (in isoform 3)	Phosphorylation	-	17.93	27251275
513	Phosphorylation	GNTVADGYSSSDSFT CCCCCCCCCCCCCCC	13.11	28450419
513 (in isoform 3)	Phosphorylation	-	13.11	20363803
514	Phosphorylation	NTVADGYSSSDSFTS CCCCCCCCCCCCCCC	28.97	28450419
514 (in isoform 3)	Phosphorylation	-	28.97	22115753
515	Phosphorylation	TVADGYSSSDSFTSD CCCCCCCCCCCCCCC	29.67	28450419
515 (in isoform 3)	Phosphorylation	-	29.67	22115753
516	Phosphorylation	VADGYSSSDSFTSDP CCCCCCCCCCCCCCH	31.19	28450419
517	Phosphorylation	ADGYSSSDSFTSDPE CCCCCCCCCCCCCHH	50.12	24719451
517 (in isoform 3)	Phosphorylation	-	50.12	22115753
518	Phosphorylation	DGYSSSDSFTSDPEQ CCCCCCCCCCCCHHH	32.16	28450419
519 (in isoform 3)	Phosphorylation	-	10.21	20363803
520	Phosphorylation	YSSSDSFTSDPEQIG CCCCCCCCCCHHHHC	35.85	28450419
520 (in isoform 3)	Phosphorylation	-	35.85	22115753
521	Phosphorylation	SSSDSFTSDPEQIGS CCCCCCCCCHHHHCC	49.51	20363803
528	Phosphorylation	SDPEQIGSNVTRQRS CCHHHHCCCCCCCCC	29.74	23090842
529	Phosphorylation	DPEQIGSNVTRQRSH CHHHHCCCCCCCCCC	33.69	24719451
531	Phosphorylation	EQIGSNVTRQRSHSG HHHCCCCCCCCCCCC	25.90	24719451
534 (in isoform 3)	Phosphorylation	-	32.80	-
535	Phosphorylation	SNVTRQRSHSGTSPD CCCCCCCCCCCCCCC	17.42	23401153
536 (in isoform 3)	Phosphorylation	-	32.22	27251275
537	Phosphorylation	VTRQRSHSGTSPDNT CCCCCCCCCCCCCCC	45.04	25159151
538 (in isoform 3)	Phosphorylation	-	25.45	27251275
539	Phosphorylation	RQRSHSGTSPDNTAP CCCCCCCCCCCCCCC	39.85	25159151
539 (in isoform 3)	Phosphorylation	-	39.85	27251275
540	Phosphorylation	QRSHSGTSPDNTAPP CCCCCCCCCCCCCCC	33.51	23927012
543 (in isoform 3)	Phosphorylation	-	41.34	27251275
544	Phosphorylation	SGTSPDNTAPPPPPP CCCCCCCCCCCCCCC	48.17	23401153
556	Phosphorylation	PPPRPQPSHSRSSSL CCCCCCCCCCCCCCC	28.93	30278072
557 (in isoform 3)	Phosphorylation	-	33.63	27251275
558	Phosphorylation	PRPQPSHSRSSSLDM CCCCCCCCCCCCCCC	37.89	30278072
560	Phosphorylation	PQPSHSRSSSLDMNR CCCCCCCCCCCCCCC	27.56	22167270
560 (in isoform 3)	Phosphorylation	-	27.56	27251275
561	Phosphorylation	QPSHSRSSSLDMNRT CCCCCCCCCCCCCCE	33.53	22167270
561 (in isoform 3)	Phosphorylation	-	33.53	-
562	Phosphorylation	PSHSRSSSLDMNRTF CCCCCCCCCCCCCEE	29.63	29255136
567 (in isoform 3)	Phosphorylation	-	25.28	-
568	Phosphorylation	SSLDMNRTFTVTTGQ CCCCCCCEEEEEECC	20.75	20068231
570	Phosphorylation	LDMNRTFTVTTGQQQ CCCCCEEEEEECCCC	19.14	20068231
572	Phosphorylation	MNRTFTVTTGQQQAG CCCEEEEEECCCCCC	23.35	20068231
573	Phosphorylation	NRTFTVTTGQQQAGV CCEEEEEECCCCCCE	28.76	20068231
612	Phosphorylation	VDADGLITHTSTSPQ CCCCCEEEECCCCCC	24.92	26074081
614	Phosphorylation	ADGLITHTSTSPQQI CCCEEEECCCCCCCC	25.67	26074081
615	Phosphorylation	DGLITHTSTSPQQIP CCEEEECCCCCCCCC	21.20	26074081
616	Phosphorylation	GLITHTSTSPQQIPE CEEEECCCCCCCCCC	45.65	26074081
617	Phosphorylation	LITHTSTSPQQIPEQ EEEECCCCCCCCCCC	22.07	26074081
662	Phosphorylation	VLPAEKASDPASSLR CCCHHHHCCHHHHCE	56.02	26074081
666	Phosphorylation	EKASDPASSLRVAKT HHHCCHHHHCEEEEC	34.98	26074081
667	Phosphorylation	KASDPASSLRVAKTD HHCCHHHHCEEEECC	23.46	26074081
673	Phosphorylation	SSLRVAKTDSKTEEK HHCEEEECCCCCCCH	35.45	26074081
675	Phosphorylation	LRVAKTDSKTEEKTA CEEEECCCCCCCHHH	46.86	26074081
677	Phosphorylation	VAKTDSKTEEKTAAS EEECCCCCCCHHHHC	54.02	26074081
681	Phosphorylation	DSKTEEKTAASAPAN CCCCCCHHHHCCCCC	30.64	26074081
682	Phosphorylation	SKTEEKTAASAPANV CCCCCHHHHCCCCCC	15.53	24719451
684	Phosphorylation	TEEKTAASAPANVSK CCCHHHHCCCCCCCC	32.11	26074081
690	Phosphorylation	ASAPANVSKGTTPLA HCCCCCCCCCCCCCC	25.77	26074081
693	Phosphorylation	PANVSKGTTPLAPPP CCCCCCCCCCCCCCC	29.04	26074081
693 (in isoform 3)	Phosphorylation	-	29.04	27251275
694	Phosphorylation	ANVSKGTTPLAPPPK CCCCCCCCCCCCCCC	25.60	29496963
708	Ubiquitination	KPVRRRLKSEDELRP CCCHHCCCCCCCCCH	50.41	-
708 (in isoform 3)	Phosphorylation	-	50.41	27251275
709	Phosphorylation	PVRRRLKSEDELRPE CCHHCCCCCCCCCHH	55.67	29255136
721	Phosphorylation	RPEVDEHTQKTGVLA CHHHHHHHHHHHHHH	29.70	23927012
724	Phosphorylation	VDEHTQKTGVLAAVL HHHHHHHHHHHHHHH	23.78	28464451
733	Phosphorylation	VLAAVLASQPSIPRS HHHHHHHCCCCCCCC	38.16	30108239
735 (in isoform 3)	Phosphorylation	-	31.56	27251275
736	Phosphorylation	AVLASQPSIPRSVGK HHHHCCCCCCCCCCC	37.27	22617229
739 (in isoform 3)	Phosphorylation	-	42.16	-
740	Phosphorylation	SQPSIPRSVGKDKKA CCCCCCCCCCCCHHH	29.84	22199227
750 (in isoform 3)	Phosphorylation	-	10.79	-
751	Phosphorylation	DKKAIQASIRRNKET CHHHHHHHHHHCCHH	10.55	22817900
758	Phosphorylation	SIRRNKETNTVLARL HHHHCCHHHHHHHHH	37.49	21406692
760	Phosphorylation	RRNKETNTVLARLNS HHCCHHHHHHHHHHH	25.06	21406692
766 (in isoform 3)	Phosphorylation	-	28.08	27251275
767	Phosphorylation	TVLARLNSELQQQLK HHHHHHHHHHHHHHH	44.25	30266825
793 (in isoform 3)	Phosphorylation	-	6.09	27251275
794	Phosphorylation	LEQLRPFSHL----- HHHHCCCCCC-----	26.94	27251275

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of REPS1_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of REPS1_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of REPS1_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
RBP1_HUMAN	RALBP1	physical	9395447
RFIP2_HUMAN	RAB11FIP2	physical	12364336
REPS1_HUMAN	REPS1	physical	21988832
WWC2_HUMAN	WWC2	physical	21988832
NUMB_MOUSE	Numb	physical	23211419
AAK1_HUMAN	AAK1	physical	28514442
REPS2_HUMAN	REPS2	physical	28514442
PNMA1_HUMAN	PNMA1	physical	28514442
BMP2K_HUMAN	BMP2K	physical	28514442
PNMA2_HUMAN	PNMA2	physical	28514442
AP2A2_HUMAN	AP2A2	physical	28514442
AP2A1_HUMAN	AP2A1	physical	28514442
TRI11_HUMAN	TRIM11	physical	28514442

Drug and Disease Associations

Kegg Disease
There are no disease associations of PTM sites.
OMIM Disease
There are no disease associations of PTM sites.
Kegg Drug
There are no disease associations of PTM sites.
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of REPS1_HUMAN

Related Literatures of Post-Translational Modification

Phosphorylation
Reference	PubMed
"Quantitative phosphoproteomic analysis of T cell receptor signalingreveals system-wide modulation of protein-protein interactions."; Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K.,Rodionov V., Han D.K.; Sci. Signal. 2:RA46-RA46(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162; SER-166; SER-170;THR-173; SER-272; SER-540 AND SER-709, AND MASS SPECTROMETRY.	19690332 [Abstract]
"Large-scale proteomics analysis of the human kinome."; Oppermann F.S., Gnad F., Olsen J.V., Hornberger R., Greff Z., Keri G.,Mann M., Daub H.; Mol. Cell. Proteomics 8:1751-1764(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-143; SER-272; THR-481AND SER-562, AND MASS SPECTROMETRY.	19369195 [Abstract]
"Lys-N and trypsin cover complementary parts of the phosphoproteome ina refined SCX-based approach."; Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J.,Mohammed S.; Anal. Chem. 81:4493-4501(2009). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-166; SER-170; THR-173;SER-174; SER-392; SER-535; SER-537; THR-539; SER-562 AND SER-709, ANDMASS SPECTROMETRY.	19413330 [Abstract]
"Large-scale phosphoproteome analysis of human liver tissue byenrichment and fractionation of phosphopeptides with strong anionexchange chromatography."; Han G., Ye M., Zhou H., Jiang X., Feng S., Jiang X., Tian R., Wan D.,Zou H., Gu J.; Proteomics 8:1346-1361(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-709, AND MASSSPECTROMETRY.	18318008 [Abstract]
"A quantitative atlas of mitotic phosphorylation."; Dephoure N., Zhou C., Villen J., Beausoleil S.A., Bakalarski C.E.,Elledge S.J., Gygi S.P.; Proc. Natl. Acad. Sci. U.S.A. 105:10762-10767(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-162; SER-166; SER-170;THR-173; SER-174 AND SER-307, AND MASS SPECTROMETRY.	18669648 [Abstract]
"Kinase-selective enrichment enables quantitative phosphoproteomics ofthe kinome across the cell cycle."; Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R.,Greff Z., Keri G., Stemmann O., Mann M.; Mol. Cell 31:438-448(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-272, AND MASSSPECTROMETRY.	18691976 [Abstract]
"Combining protein-based IMAC, peptide-based IMAC, and MudPIT forefficient phosphoproteomic analysis."; Cantin G.T., Yi W., Lu B., Park S.K., Xu T., Lee J.-D.,Yates J.R. III; J. Proteome Res. 7:1346-1351(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-118; SER-162; SER-170;THR-173 AND SER-174, AND MASS SPECTROMETRY.	18220336 [Abstract]
"Phosphoproteome of resting human platelets."; Zahedi R.P., Lewandrowski U., Wiesner J., Wortelkamp S., Moebius J.,Schuetz C., Walter U., Gambaryan S., Sickmann A.; J. Proteome Res. 7:526-534(2008). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-562, AND MASSSPECTROMETRY.	18088087 [Abstract]
"Global, in vivo, and site-specific phosphorylation dynamics insignaling networks."; Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P.,Mann M.; Cell 127:635-648(2006). Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-489 AND SER-751, ANDMASS SPECTROMETRY.	17081983 [Abstract]