ABCB9_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ABCB9_HUMAN
• UniProt AC: Q9NP78
• Protein Name: ATP-binding cassette sub-family B member 9
• Gene Name: ABCB9
• Organism: Homo sapiens (Human).
• Sequence Length: 766
• Subcellular Localization: Lysosome membrane ; Multi-pass membrane protein . May be located in membrane rafts.
• Protein Description: ATP-dependent low-affinity peptide transporter which translocates a broad spectrum of peptides from the cytosol to the lysosomal lumen. Displays a broad peptide length specificity from 6-mer up to at least 59-mer peptides with an optimum of 23-mers. Favors positively charged, aromatic or hydrophobic residues in the N- and C-terminal positions whereas negatively charged residues as well as asparagine and methionine are not favored..
• Protein Sequence: MRLWKAVVVTLAFMSVDICVTTAIYVFSHLDRSLLEDIRHFNIFDSVLDLWAACLYRSCLLLGATIGVAKNSALGPRRLRASWLVITLVCLFVGIYAMVKLLLFSEVRRPIRDPWFWALFVWTYISLGASFLLWWLLSTVRPGTQALEPGAATEAEGFPGSGRPPPEQASGATLQKLLSYTKPDVAFLVAASFFLIVAALGETFLPYYTGRAIDGIVIQKSMDQFSTAVVIVCLLAIGSSFAAGIRGGIFTLIFARLNIRLRNCLFRSLVSQETSFFDENRTGDLISRLTSDTTMVSDLVSQNINVFLRNTVKVTGVVVFMFSLSWQLSLVTFMGFPIIMMVSNIYGKYYKRLSKEVQNALARASNTAEETISAMKTVRSFANEEEEAEVYLRKLQQVYKLNRKEAAAYMYYVWGSGLTLLVVQVSILYYGGHLVISGQMTSGNLIAFIIYEFVLGDCMESVGSVYSGLMQGVGAAEKVFEFIDRQPTMVHDGSLAPDHLEGRVDFENVTFTYRTRPHTQVLQNVSFSLSPGKVTALVGPSGSGKSSCVNILENFYPLEGGRVLLDGKPISAYDHKYLHRVISLVSQEPVLFARSITDNISYGLPTVPFEMVVEAAQKANAHGFIMELQDGYSTETGEKGAQLSGGQKQRVAMARALVRNPPVLILDEATSALDAESEYLIQQAIHGNLQKHTVLIIAHRLSTVEHAHLIVVLDKGRVVQQGTHQQLLAQGGLYAKLVQRQMLGLQPAADFTAGHNEPVANGSHKA

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
105	Phosphorylation	MVKLLLFSEVRRPIR HHHHHHHHHCCCCCC	34.84	24719451
227	Phosphorylation	KSMDQFSTAVVIVCL CCHHHHHHHHHHHHH	25.43	24719451
240	Phosphorylation	CLLAIGSSFAAGIRG HHHHHHHHHHHHHHH	17.43	24719451
325	Phosphorylation	VVFMFSLSWQLSLVT EEEEEEHHHHHHHHH	16.16	22210691
355	Methylation	KYYKRLSKEVQNALA HHHHHHHHHHHHHHH	67.50	-
376	Ubiquitination	EETISAMKTVRSFAN HHHHHHHHHHHHHCC	43.51	2190698
376 (in isoform 1)	Ubiquitination	-	43.51	21906983
376 (in isoform 2)	Ubiquitination	-	43.51	21906983
376 (in isoform 3)	Ubiquitination	-	43.51	21906983
394	Ubiquitination	EAEVYLRKLQQVYKL HHHHHHHHHHHHHHC	48.31	-
418 (in isoform 2)	Phosphorylation	-	3.06	22210691
528	Phosphorylation	VLQNVSFSLSPGKVT EEEEEEEEECCCEEE	22.04	26437602
530	Phosphorylation	QNVSFSLSPGKVTAL EEEEEEECCCEEEEE	30.34	21406692
648	Ubiquitination	AQLSGGQKQRVAMAR CCCCCHHHHHHHHHH	43.26	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ABCB9_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ABCB9_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ABCB9_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
DDX6L_HUMAN	DDX60L	physical	26344197

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Large-scale characterization of HeLa cell nuclear phosphoproteins.";
Beausoleil S.A., Jedrychowski M., Schwartz D., Elias J.E., Villen J.,Li J., Cohn M.A., Cantley L.C., Gygi S.P.;
Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-530, AND MASSSPECTROMETRY.
PubMed: 15302935