H17B6_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: H17B6_HUMAN
• UniProt AC: O14756
• Protein Name: 17-beta-hydroxysteroid dehydrogenase type 6
• Gene Name: HSD17B6
• Organism: Homo sapiens (Human).
• Sequence Length: 317
• Subcellular Localization: Microsome membrane ; Peripheral membrane protein ; Lumenal side . Early endosome membrane ; Peripheral membrane protein ; Lumenal side .
• Protein Description: NAD-dependent oxidoreductase with broad substrate specificity that shows both oxidative and reductive activity (in vitro). Has 17-beta-hydroxysteroid dehydrogenase activity towards various steroids (in vitro). Converts 5-alpha-androstan-3-alpha,17-beta-diol to androsterone and estradiol to estrone (in vitro). Has 3-alpha-hydroxysteroid dehydrogenase activity towards androsterone (in vitro). Has retinol dehydrogenase activity towards all-trans-retinol (in vitro). Can convert androsterone to epi-androsterone. Androsterone is first oxidized to 5-alpha-androstane-3,17-dione and then reduced to epi-andosterone. Can act on both C-19 and C-21 3-alpha-hydroxysteroids..
• Protein Sequence: MWLYLAAFVGLYYLLHWYRERQVVSHLQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVTLDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTEDSMNMLKVNLIGVIQVTLSMLPLVRRARGRIVNVSSILGRVAFFVGGYCVSKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGMTNMTQSLERMKQSWKEAPKHIKETYGQQYFDALYNIMKEGLLNCSTNLNLVTDCMEHALTSVHPRTRYSAGWDAKFFFIPLSYLPTSLADYILTRSWPKPAQAV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
64	Ubiquitination	LAACLTEKGAEQLRG HHHHHCHHHHHHHCC	59.18	-
161	N-linked_Glycosylation	RARGRIVNVSSILGR HHCCCEEEHHHHHHH	26.11	UniProtKB CARBOHYD
202	Phosphorylation	QHFGVKISIVEPGYF HHHCCEEEEECCCCC	18.18	-
215	N-linked_Glycosylation	YFRTGMTNMTQSLER CCCCCCCHHHHHHHH	23.70	UniProtKB CARBOHYD
256	N-linked_Glycosylation	IMKEGLLNCSTNLNL HHHHCCCCCCCCCHH	23.80	UniProtKB CARBOHYD
274	Phosphorylation	CMEHALTSVHPRTRY HHHHHHHCCCCCCCC	21.19	22210691
279	Phosphorylation	LTSVHPRTRYSAGWD HHCCCCCCCCCCCCC	38.11	22210691
281	Phosphorylation	SVHPRTRYSAGWDAK CCCCCCCCCCCCCCE	11.40	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of H17B6_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of H17B6_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of H17B6_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
AT12A_HUMAN	ATP12A	physical	26186194
NFH_HUMAN	NEFH	physical	26186194
AT2B1_HUMAN	ATP2B1	physical	26186194
AT2B4_HUMAN	ATP2B4	physical	26186194
AT2B2_HUMAN	ATP2B2	physical	26186194
AT2B3_HUMAN	ATP2B3	physical	26186194
TATD1_HUMAN	TATDN1	physical	26186194
PRDC1_HUMAN	PRTFDC1	physical	26186194
SNX3_HUMAN	SNX3	physical	26186194
KPRP_HUMAN	KPRP	physical	26186194
AT2B3_HUMAN	ATP2B3	physical	28514442
AT2B4_HUMAN	ATP2B4	physical	28514442
PRDC1_HUMAN	PRTFDC1	physical	28514442
TATD1_HUMAN	TATDN1	physical	28514442
AT2B1_HUMAN	ATP2B1	physical	28514442
PP14B_HUMAN	PPP1R14B	physical	28514442
GNA1_HUMAN	GNPNAT1	physical	28514442
AT12A_HUMAN	ATP12A	physical	28514442
SNX3_HUMAN	SNX3	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.