P2RY2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: P2RY2_HUMAN
• UniProt AC: P41231
• Protein Name: P2Y purinoceptor 2
• Gene Name: P2RY2
• Organism: Homo sapiens (Human).
• Sequence Length: 377
• Subcellular Localization: Cell membrane; Multi-pass membrane protein.
• Protein Description: Receptor for ATP and UTP coupled to G-proteins that activate a phosphatidylinositol-calcium second messenger system. The affinity range is UTP = ATP > ATP-gamma-S >> 2-methylthio-ATP = ADP..
• Protein Sequence: MAADLGPWNDTINGTWDGDELGYRCRFNEDFKYVLLPVSYGVVCVPGLCLNAVALYIFLCRLKTWNASTTYMFHLAVSDALYAASLPLLVYYYARGDHWPFSTVLCKLVRFLFYTNLYCSILFLTCISVHRCLGVLRPLRSLRWGRARYARRVAGAVWVLVLACQAPVLYFVTTSARGGRVTCHDTSAPELFSRFVAYSSVMLGLLFAVPFAVILVCYVLMARRLLKPAYGTSGGLPRAKRKSVRTIAVVLAVFALCFLPFHVTRTLYYSFRSLDLSCHTLNAINMAYKVTRPLASANSCLDPVLYFLAGQRLVRFARDAKPPTGPSPATPARRRLGLRRSDRTDMQRIEDVLGSSEDSRRTESTPAGSENTKDIRL

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
9	N-linked_Glycosylation	AADLGPWNDTINGTW CCCCCCCCCCCCCCC	39.41	UniProtKB CARBOHYD
13	N-linked_Glycosylation	GPWNDTINGTWDGDE CCCCCCCCCCCCCCC	43.89	UniProtKB CARBOHYD
227	Ubiquitination	LMARRLLKPAYGTSG HHHHHHHCHHHCCCC	31.99	22817900
230	Phosphorylation	RRLLKPAYGTSGGLP HHHHCHHHCCCCCCC	29.48	17929957
233	Phosphorylation	LKPAYGTSGGLPRAK HCHHHCCCCCCCHHH	26.88	17929957
243	Phosphorylation	LPRAKRKSVRTIAVV CCHHHHHHHHHHHHH	22.36	22817900
324	Phosphorylation	ARDAKPPTGPSPATP HHCCCCCCCCCCCCH	70.97	28450419
327	Phosphorylation	AKPPTGPSPATPARR CCCCCCCCCCCHHHH	28.63	25849741
330	Phosphorylation	PTGPSPATPARRRLG CCCCCCCCHHHHHHC	22.36	28450419
344	Phosphorylation	GLRRSDRTDMQRIED CCCCCCCCCHHHHHH	40.59	22817900
355	Phosphorylation	RIEDVLGSSEDSRRT HHHHHHCCCCCCCCC	26.79	28450419
356	Phosphorylation	IEDVLGSSEDSRRTE HHHHHCCCCCCCCCC	43.56	28450419
359	Phosphorylation	VLGSSEDSRRTESTP HHCCCCCCCCCCCCC	21.43	25849741
364	Phosphorylation	EDSRRTESTPAGSEN CCCCCCCCCCCCCCC	38.79	25003641
369	Phosphorylation	TESTPAGSENTKDIR CCCCCCCCCCCCCCC	29.76	-

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of P2RY2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of P2RY2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
355	Phosphorylation	359 (4)	S ⇒ P	rs74472890	Basophil percentage of granulocytes	27863252
356	Phosphorylation	359 (3)	S ⇒ P	rs74472890	Basophil percentage of granulocytes	27863252
359	Phosphorylation	359 (0)	S ⇒ P	rs74472890	Basophil percentage of granulocytes	27863252
364	Phosphorylation	359 (5)	S ⇒ P	rs74472890	Basophil percentage of granulocytes	27863252
369	Phosphorylation	359 (10)	S ⇒ P	rs74472890	Basophil percentage of granulocytes	27863252

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
SRC_HUMAN	SRC	physical	14670955

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.