dbPTM

DMAC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	DMAC2_HUMAN
UniProt AC	Q9NW81
Protein Name	Distal membrane-arm assembly complex protein 2 {ECO:0000305}
Gene Name	DMAC2 {ECO:0000312\|HGNC:HGNC:25496}
Organism	Homo sapiens (Human).
Sequence Length	257
Subcellular Localization	Mitochondrion .
Protein Description	Required for the assembly of the mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). Involved in the assembly of the distal region of complex I..
Protein Sequence	MAAPWASLRLVAPMWNGRIRGIHRLGAAVAPEGNQKKKRTILQFLTNYFYDVEALRDYLLQREMYKVHEKNRSYTWLEKQHGPYGAGAFFILKQGGAVKFRDKEWIRPDKYGHFSQEFWNFCEVPVEAVDAGDCDINYEGLDNLLRLKELQSLSLQRCCHVDDWCLSRLYPLADSLQELSLAGCPRISERGLACLHHLQNLRRLDISDLPAVSNPGLTQILVEEMLPNCEVVGVDWAEGLKSGPEEQPRDTASPVPA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	Reference
7	Phosphorylation	-MAAPWASLRLVAPM -CCCCCHHHEEEECC	24043423
58	Phosphorylation	DVEALRDYLLQREMY CHHHHHHHHHHHHHH	-
65	Phosphorylation	YLLQREMYKVHEKNR HHHHHHHHHHHHHHH	-
74	Phosphorylation	VHEKNRSYTWLEKQH HHHHHHCCCHHHHHC	-
84	Phosphorylation	LEKQHGPYGAGAFFI HHHHCCCCCCCEEEE	-
103	Acetylation	GAVKFRDKEWIRPDK CEEEECCCCCCCCCC	20167786
152	Phosphorylation	LRLKELQSLSLQRCC HHHHHHHHCCCHHHC	24114839
154	Phosphorylation	LKELQSLSLQRCCHV HHHHHHCCCHHHCCC	24719451
242	Phosphorylation	DWAEGLKSGPEEQPR EHHHHHCCCCCCCCC	23186163
251	Phosphorylation	PEEQPRDTASPVPA- CCCCCCCCCCCCCC-	23403867
253	Phosphorylation	EQPRDTASPVPA--- CCCCCCCCCCCC---	28355574
259	Phosphorylation	ASPVPA--------- CCCCCC---------	24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of DMAC2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of DMAC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of DMAC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
Oops, there are no PPI records of DMAC2_HUMAN !!

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of DMAC2_HUMAN

Related Literatures of Post-Translational Modification