PLPP_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: PLPP_HUMAN
• UniProt AC: Q96GD0
• Protein Name: Pyridoxal phosphate phosphatase
• Gene Name: PDXP
• Organism: Homo sapiens (Human).
• Sequence Length: 296
• Subcellular Localization: Cytoplasm, cytosol . Cytoplasm, cytoskeleton . Cell projection, ruffle membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell projection, lamellipodium membrane ; Peripheral membrane protein ; Cytoplasmic side . Cell membrane ; Peripheral membra
• Protein Description: Protein serine phosphatase that dephosphorylates 'Ser-3' in cofilin and probably also dephosphorylates phospho-serine residues in DSTN. Regulates cofilin-dependent actin cytoskeleton reorganization. Required for normal progress through mitosis and normal cytokinesis. Does not dephosphorylate phospho-threonines in LIMK1. Does not dephosphorylate peptides containing phospho-tyrosine. PNP > PMP' target='_blank'> [PubMed: 15580268 Pyridoxal phosphate (PLP) phosphatase, which also catalyzes the dephosphorylation of pyridoxine 5'-phosphate (PNP) and pyridoxamine 5'-phosphate (PMP), with order of substrate preference PLP > PNP > PMP]
• Protein Sequence: MARCERLRGAALRDVLGRAQGVLFDCDGVLWNGERAVPGAPELLERLARAGKAALFVSNNSRRARPELALRFARLGFGGLRAEQLFSSALCAARLLRQRLPGPPDAPGAVFVLGGEGLRAELRAAGLRLAGDPSAGDGAAPRVRAVLVGYDEHFSFAKLREACAHLRDPECLLVATDRDPWHPLSDGSRTPGTGSLAAAVETASGRQALVVGKPSPYMFECITENFSIDPARTLMVGDRLETDILFGHRCGMTTVLTLTGVSRLEEAQAYLAAGQHDLVPHYYVESIADLTEGLED

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
52	Ubiquitination	ERLARAGKAALFVSN HHHHHCCCCEEEEEC	29.51	-
58	Phosphorylation	GKAALFVSNNSRRAR CCCEEEEECCCCCCC	23.98	29083192
61	Phosphorylation	ALFVSNNSRRARPEL EEEEECCCCCCCHHH	27.65	29083192
128	Methylation	ELRAAGLRLAGDPSA HHHHHCCCCCCCCCC	22.90	115486971
158	Acetylation	DEHFSFAKLREACAH HHCCCHHHHHHHHHH	46.17	25953088
176	Phosphorylation	PECLLVATDRDPWHP CCCEEEEECCCCCCC	24.88	20068231
190	Phosphorylation	PLSDGSRTPGTGSLA CCCCCCCCCCCCCHH	27.97	21406692
193	Phosphorylation	DGSRTPGTGSLAAAV CCCCCCCCCCHHHHE	25.46	21406692
195	Phosphorylation	SRTPGTGSLAAAVET CCCCCCCCHHHHEEE	18.05	21406692
202	Phosphorylation	SLAAAVETASGRQAL CHHHHEEECCCCEEE	21.37	21406692
204	Phosphorylation	AAAVETASGRQALVV HHHEEECCCCEEEEE	41.76	21406692
254	Phosphorylation	GHRCGMTTVLTLTGV CCCCCCEEEEHHHCC	12.48	22210691
257	Phosphorylation	CGMTTVLTLTGVSRL CCCEEEEHHHCCCHH	20.24	22210691

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of PLPP_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of PLPP_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of PLPP_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
ARRB1_HUMAN	ARRB1	physical	17500066

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.