ZDHC7_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: ZDHC7_HUMAN
• UniProt AC: Q9NXF8
• Protein Name: Palmitoyltransferase ZDHHC7 {ECO:0000305}
• Gene Name: ZDHHC7 {ECO:0000312|HGNC:HGNC:18459}
• Organism: Homo sapiens (Human).
• Sequence Length: 308
• Subcellular Localization: Golgi apparatus membrane ; Multi-pass membrane protein .
• Protein Description: Palmitoyltransferase with broad specificity. Palmitoylates SNAP25 and DLG4/PSD95 (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones. [PubMed: 22031296 May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity]
• Protein Sequence: MQPSGHRLRDVEHHPLLAENDNYDSSSSSSSEADVADRVWFIRDGCGMICAVMTWLLVAYADFVVTFVMLLPSKDFWYSVVNGVIFNCLAVLALSSHLRTMLTDPGAVPKGNATKEYMESLQLKPGEVIYKCPKCCCIKPERAHHCSICKRCIRKMDHHCPWVNNCVGEKNQRFFVLFTMYIALSSVHALILCGFQFISCVRGQWTECSDFSPPITVILLIFLCLEGLLFFTFTAVMFGTQIHSICNDETEIERLKSEKPTWERRLRWEGMKSVFGGPPSLLWMNPFVGFRFRRLPTRPRKGGPEFSV

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
23	Phosphorylation	LLAENDNYDSSSSSS CCCCCCCCCCCCCCC	21.77	27642862
25	Phosphorylation	AENDNYDSSSSSSSE CCCCCCCCCCCCCCH	23.04	29978859
26	Phosphorylation	ENDNYDSSSSSSSEA CCCCCCCCCCCCCHH	31.20	29978859
27	Phosphorylation	NDNYDSSSSSSSEAD CCCCCCCCCCCCHHH	37.89	29978859
28	Phosphorylation	DNYDSSSSSSSEADV CCCCCCCCCCCHHHH	35.87	29978859
73	Phosphorylation	TFVMLLPSKDFWYSV HHHHHCCCCCHHHHH	44.84	24719451
110	Ubiquitination	TDPGAVPKGNATKEY CCCCCCCCCCCCHHH	59.19	2190698
110 (in isoform 1)	Ubiquitination	-	59.19	21906983
115	Ubiquitination	VPKGNATKEYMESLQ CCCCCCCHHHHHHCC	44.42	32015554
117	Phosphorylation	KGNATKEYMESLQLK CCCCCHHHHHHCCCC	14.03	-
120	Phosphorylation	ATKEYMESLQLKPGE CCHHHHHHCCCCCCC	12.60	-
124	Ubiquitination	YMESLQLKPGEVIYK HHHHCCCCCCCEEEE	37.71	32015554
130	Phosphorylation	LKPGEVIYKCPKCCC CCCCCEEEECCCCEE	16.24	26356563
131	Acetylation	KPGEVIYKCPKCCCI CCCCEEEECCCCEEE	32.70	25953088
131	Ubiquitination	KPGEVIYKCPKCCCI CCCCEEEECCCCEEE	32.70	33845483
139	Ubiquitination	CPKCCCIKPERAHHC CCCCEEECHHHHHCC	27.23	-
152	Ubiquitination	HCSICKRCIRKMDHH CCHHHHHHHHHCCCC	1.84	32015554
161	Ubiquitination	RKMDHHCPWVNNCVG HHCCCCCCCHHHCCC	33.42	32015554
168	Ubiquitination	PWVNNCVGEKNQRFF CCHHHCCCCCCHHHH	42.22	33845483
176 (in isoform 2)	Ubiquitination	-	3.85	-
179	Phosphorylation	QRFFVLFTMYIALSS HHHHHHHHHHHHHHH	12.61	24719451
185	Phosphorylation	FTMYIALSSVHALIL HHHHHHHHHHHHHHH	22.69	24719451
186	Phosphorylation	TMYIALSSVHALILC HHHHHHHHHHHHHHC	20.83	24719451
216	Phosphorylation	SDFSPPITVILLIFL CCCCCHHHHHHHHHH	13.78	24719451
222	Phosphorylation	ITVILLIFLCLEGLL HHHHHHHHHHHHHHH	3.88	24719451
223	Phosphorylation	TVILLIFLCLEGLLF HHHHHHHHHHHHHHH	2.30	24719451
256	Ubiquitination	ETEIERLKSEKPTWE HHHHHHHHCCCCCHH	63.89	-
259	Ubiquitination	IERLKSEKPTWERRL HHHHHCCCCCHHHHH	55.63	33845483
293 (in isoform 2)	Ubiquitination	-	34.66	-
296	Ubiquitination	GFRFRRLPTRPRKGG CEEEEECCCCCCCCC	25.26	33845483
297	Phosphorylation	FRFRRLPTRPRKGGP EEEEECCCCCCCCCC	58.87	-
301	Ubiquitination	RLPTRPRKGGPEFSV ECCCCCCCCCCCCCC	71.54	33845483
307	Phosphorylation	RKGGPEFSV------ CCCCCCCCC------	25.84	23403867
338	Ubiquitination	------------------------------------- -------------------------------------		33845483
344	Phosphorylation	------------------------------------------- -------------------------------------------		24719451

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of ZDHC7_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of ZDHC7_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of ZDHC7_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
A4_HUMAN	APP	physical	21832049
KCRM_HUMAN	CKM	physical	26186194
MBRL_HUMAN	TMEM259	physical	26186194
REEP5_HUMAN	REEP5	physical	26186194
NFIP1_HUMAN	NDFIP1	physical	26186194
TM186_HUMAN	TMEM186	physical	26186194
MARH6_HUMAN	MARCH6	physical	26186194
KCRM_HUMAN	CKM	physical	28514442
MARH6_HUMAN	MARCH6	physical	28514442
TM186_HUMAN	TMEM186	physical	28514442
NFIP1_HUMAN	NDFIP1	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.