UniProt ID | KCRM_HUMAN | |
---|---|---|
UniProt AC | P06732 | |
Protein Name | Creatine kinase M-type | |
Gene Name | CKM | |
Organism | Homo sapiens (Human). | |
Sequence Length | 381 | |
Subcellular Localization | Cytoplasm. | |
Protein Description | Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa.. | |
Protein Sequence | MPFGNTHNKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRDKETPSGFTVDDVIQTGVDNPGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEKEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK | |
Overview of Protein Modification Sites with Functional and Structural Information | ||
* ASA = Accessible Surface Area
Locations | Modification | Substrate Peptides & Secondary Structure |
ASA (%) | Reference | Orthologous Protein Cluster |
---|---|---|---|---|---|
14 | Phosphorylation | HNKFKLNYKPEEEYP CCCCCCCCCCHHHCC | 38.05 | - | |
14 | Nitration | HNKFKLNYKPEEEYP CCCCCCCCCCHHHCC | 38.05 | - | |
20 | Phosphorylation | NYKPEEEYPDLSKHN CCCCHHHCCCHHHCC | 12.82 | 19764811 | |
20 | Nitration | NYKPEEEYPDLSKHN CCCCHHHCCCHHHCC | 12.82 | - | |
24 | Phosphorylation | EEEYPDLSKHNNHMA HHHCCCHHHCCCHHH | 38.97 | 26437602 | |
35 | Phosphorylation | NHMAKVLTLELYKKL CHHHHHHHHHHHHHH | 22.60 | 19764811 | |
39 | Phosphorylation | KVLTLELYKKLRDKE HHHHHHHHHHHCCCC | 9.19 | - | |
40 | Acetylation | VLTLELYKKLRDKET HHHHHHHHHHCCCCC | 58.94 | 30585839 | |
41 | Acetylation | LTLELYKKLRDKETP HHHHHHHHHCCCCCC | 34.89 | 30585845 | |
47 | Phosphorylation | KKLRDKETPSGFTVD HHHCCCCCCCCCCHH | 28.61 | 22673903 | |
52 | Phosphorylation | KETPSGFTVDDVIQT CCCCCCCCHHHHHHH | 26.93 | 22673903 | |
59 | Phosphorylation | TVDDVIQTGVDNPGH CHHHHHHHCCCCCCC | 28.22 | 22673903 | |
71 | Phosphorylation | PGHPFIMTVGCVAGD CCCCEEEEEEEECCC | 14.66 | 22673903 | |
81 | Phosphorylation | CVAGDEESYEVFKEL EECCCHHHHHHHHHH | 25.25 | 22673903 | |
82 | Phosphorylation | VAGDEESYEVFKELF ECCCHHHHHHHHHHH | 21.28 | 22673903 | |
82 | Nitration | VAGDEESYEVFKELF ECCCHHHHHHHHHHH | 21.28 | - | |
94 | Phosphorylation | ELFDPIISDRHGGYK HHHHHHHCCCCCCCC | 29.34 | 26437602 | |
100 | Phosphorylation | ISDRHGGYKPTDKHK HCCCCCCCCCCCCCC | 20.56 | 22673903 | |
103 | Phosphorylation | RHGGYKPTDKHKTDL CCCCCCCCCCCCCCC | 54.23 | 26437602 | |
108 | Phosphorylation | KPTDKHKTDLNHENL CCCCCCCCCCCCCCC | 45.50 | 26437602 | |
125 | Phosphorylation | GDDLDPNYVLSSRVR CCCCCHHHEEECCCC | 14.25 | 20068231 | |
128 | Phosphorylation | LDPNYVLSSRVRTGR CCHHHEEECCCCCCC | 13.17 | 20068231 | |
129 | Phosphorylation | DPNYVLSSRVRTGRS CHHHEEECCCCCCCC | 30.54 | 20068231 | |
133 | Phosphorylation | VLSSRVRTGRSIKGY EEECCCCCCCCCCCC | 33.81 | - | |
136 | Phosphorylation | SRVRTGRSIKGYTLP CCCCCCCCCCCCCCC | 29.96 | - | |
140 | Phosphorylation | TGRSIKGYTLPPHCS CCCCCCCCCCCCCCC | 10.49 | 19764811 | |
141 | Phosphorylation | GRSIKGYTLPPHCSR CCCCCCCCCCCCCCH | 41.27 | 19764811 | |
164 | Phosphorylation | LSVEALNSLTGEFKG HCHHHHHHCCCCCCC | 28.32 | 19764811 | |
166 | Phosphorylation | VEALNSLTGEFKGKY HHHHHHCCCCCCCEE | 34.19 | 22777824 | |
170 | Acetylation | NSLTGEFKGKYYPLK HHCCCCCCCEEECCC | 50.63 | 19862999 | |
173 | Phosphorylation | TGEFKGKYYPLKSMT CCCCCCEEECCCCCC | 20.98 | 22817900 | |
174 | Phosphorylation | GEFKGKYYPLKSMTE CCCCCEEECCCCCCH | 12.94 | 19764811 | |
178 | Phosphorylation | GKYYPLKSMTEKEQQ CEEECCCCCCHHHHH | 38.32 | 19764811 | |
180 | Phosphorylation | YYPLKSMTEKEQQQL EECCCCCCHHHHHHH | 51.50 | 22673903 | |
199 | Phosphorylation | FLFDKPVSPLLLASG CCCCCCCHHHHHHHC | 20.54 | 22496350 | |
215 | Methylation | ARDWPDARGIWHNDN CCCCCCCCCCEECCC | 44.50 | - | |
224 | Phosphorylation | IWHNDNKSFLVWVNE CEECCCCCEEEEECH | 30.02 | 26437602 | |
247 | Acetylation | MEKGGNMKEVFRRFC EECCCCHHHHHHHHH | 55.51 | 156255 | |
265 | Acetylation | QKIEEIFKKAGHPFM HHHHHHHHHCCCCCC | 47.58 | 7923447 | |
279 | Phosphorylation | MWNQHLGYVLTCPSN CCCCCCEEEEECCCC | 9.92 | - | |
285 | Phosphorylation | GYVLTCPSNLGTGLR EEEEECCCCCCCCCC | 47.00 | 26437602 | |
303 | Phosphorylation | HVKLAHLSKHPKFEE EEEEHHHHCCCCHHH | 21.03 | 26437602 | |
313 | Phosphorylation | PKFEEILTRLRLQKR CCHHHHHHHHHHHHC | 33.06 | 19764811 | |
322 | Phosphorylation | LRLQKRGTGGVDTAA HHHHHCCCCCCCCCC | 34.49 | 19764811 | |
327 | Phosphorylation | RGTGGVDTAAVGSVF CCCCCCCCCCEECEE | 17.70 | 19764811 | |
332 | Phosphorylation | VDTAAVGSVFDVSNA CCCCCEECEEECCCC | 17.01 | 19764811 | |
337 | Phosphorylation | VGSVFDVSNADRLGS EECEEECCCCCCCCC | 28.30 | 22210691 | |
365 | Acetylation | KLMVEMEKKLEKGQS HHHHHHHHHHHCCCC | 62.44 | 19863011 | |
372 | Phosphorylation | KKLEKGQSIDDMIPA HHHHCCCCHHHCCCC | 36.33 | 22777824 |
Modified Location | Modified Residue | Modification | Function | Reference | ||
---|---|---|---|---|---|---|
Oops, there are no descriptions of PTM sites of KCRM_HUMAN !! |
* Distance = the distance between SAP position and PTM sites.
Modified Location | Modification | Variant Position (Distance <= 10) |
Residue Change | SAP | Related Disease | Reference |
---|---|---|---|---|---|---|
Oops, there are no SNP-PTM records of KCRM_HUMAN !! |
Interacting Protein | Gene Name | Interaction Type | PPI Reference | Domain-Domain Interactions |
---|---|---|---|---|
TRI63_HUMAN | TRIM63 | physical | 18222470 | |
ASB9_HUMAN | ASB9 | physical | 25416956 | |
VATC2_HUMAN | ATP6V1C2 | physical | 26186194 | |
PALM2_HUMAN | PALM2 | physical | 26186194 | |
ABCB7_HUMAN | ABCB7 | physical | 26344197 | |
ASB9_HUMAN | ASB9 | physical | 21516116 | |
VATC2_HUMAN | ATP6V1C2 | physical | 28514442 | |
PALM2_HUMAN | PALM2 | physical | 28514442 |
Kegg Disease | |
---|---|
There are no disease associations of PTM sites. | |
OMIM Disease | |
There are no disease associations of PTM sites. | |
Kegg Drug | |
There are no disease associations of PTM sites. | |
DrugBank | |
DB00148 | Creatine |
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