KCRM_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: KCRM_HUMAN
• UniProt AC: P06732
• Protein Name: Creatine kinase M-type
• Gene Name: CKM
• Organism: Homo sapiens (Human).
• Sequence Length: 381
• Subcellular Localization: Cytoplasm.
• Protein Description: Reversibly catalyzes the transfer of phosphate between ATP and various phosphogens (e.g. creatine phosphate). Creatine kinase isoenzymes play a central role in energy transduction in tissues with large, fluctuating energy demands, such as skeletal muscle, heart, brain and spermatozoa..
• Protein Sequence: MPFGNTHNKFKLNYKPEEEYPDLSKHNNHMAKVLTLELYKKLRDKETPSGFTVDDVIQTGVDNPGHPFIMTVGCVAGDEESYEVFKELFDPIISDRHGGYKPTDKHKTDLNHENLKGGDDLDPNYVLSSRVRTGRSIKGYTLPPHCSRGERRAVEKLSVEALNSLTGEFKGKYYPLKSMTEKEQQQLIDDHFLFDKPVSPLLLASGMARDWPDARGIWHNDNKSFLVWVNEEDHLRVISMEKGGNMKEVFRRFCVGLQKIEEIFKKAGHPFMWNQHLGYVLTCPSNLGTGLRGGVHVKLAHLSKHPKFEEILTRLRLQKRGTGGVDTAAVGSVFDVSNADRLGSSEVEQVQLVVDGVKLMVEMEKKLEKGQSIDDMIPAQK

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
14	Phosphorylation	HNKFKLNYKPEEEYP CCCCCCCCCCHHHCC	38.05	-
14	Nitration	HNKFKLNYKPEEEYP CCCCCCCCCCHHHCC	38.05	-
20	Phosphorylation	NYKPEEEYPDLSKHN CCCCHHHCCCHHHCC	12.82	19764811
20	Nitration	NYKPEEEYPDLSKHN CCCCHHHCCCHHHCC	12.82	-
24	Phosphorylation	EEEYPDLSKHNNHMA HHHCCCHHHCCCHHH	38.97	26437602
35	Phosphorylation	NHMAKVLTLELYKKL CHHHHHHHHHHHHHH	22.60	19764811
39	Phosphorylation	KVLTLELYKKLRDKE HHHHHHHHHHHCCCC	9.19	-
40	Acetylation	VLTLELYKKLRDKET HHHHHHHHHHCCCCC	58.94	30585839
41	Acetylation	LTLELYKKLRDKETP HHHHHHHHHCCCCCC	34.89	30585845
47	Phosphorylation	KKLRDKETPSGFTVD HHHCCCCCCCCCCHH	28.61	22673903
52	Phosphorylation	KETPSGFTVDDVIQT CCCCCCCCHHHHHHH	26.93	22673903
59	Phosphorylation	TVDDVIQTGVDNPGH CHHHHHHHCCCCCCC	28.22	22673903
71	Phosphorylation	PGHPFIMTVGCVAGD CCCCEEEEEEEECCC	14.66	22673903
81	Phosphorylation	CVAGDEESYEVFKEL EECCCHHHHHHHHHH	25.25	22673903
82	Phosphorylation	VAGDEESYEVFKELF ECCCHHHHHHHHHHH	21.28	22673903
82	Nitration	VAGDEESYEVFKELF ECCCHHHHHHHHHHH	21.28	-
94	Phosphorylation	ELFDPIISDRHGGYK HHHHHHHCCCCCCCC	29.34	26437602
100	Phosphorylation	ISDRHGGYKPTDKHK HCCCCCCCCCCCCCC	20.56	22673903
103	Phosphorylation	RHGGYKPTDKHKTDL CCCCCCCCCCCCCCC	54.23	26437602
108	Phosphorylation	KPTDKHKTDLNHENL CCCCCCCCCCCCCCC	45.50	26437602
125	Phosphorylation	GDDLDPNYVLSSRVR CCCCCHHHEEECCCC	14.25	20068231
128	Phosphorylation	LDPNYVLSSRVRTGR CCHHHEEECCCCCCC	13.17	20068231
129	Phosphorylation	DPNYVLSSRVRTGRS CHHHEEECCCCCCCC	30.54	20068231
133	Phosphorylation	VLSSRVRTGRSIKGY EEECCCCCCCCCCCC	33.81	-
136	Phosphorylation	SRVRTGRSIKGYTLP CCCCCCCCCCCCCCC	29.96	-
140	Phosphorylation	TGRSIKGYTLPPHCS CCCCCCCCCCCCCCC	10.49	19764811
141	Phosphorylation	GRSIKGYTLPPHCSR CCCCCCCCCCCCCCH	41.27	19764811
164	Phosphorylation	LSVEALNSLTGEFKG HCHHHHHHCCCCCCC	28.32	19764811
166	Phosphorylation	VEALNSLTGEFKGKY HHHHHHCCCCCCCEE	34.19	22777824
170	Acetylation	NSLTGEFKGKYYPLK HHCCCCCCCEEECCC	50.63	19862999
173	Phosphorylation	TGEFKGKYYPLKSMT CCCCCCEEECCCCCC	20.98	22817900
174	Phosphorylation	GEFKGKYYPLKSMTE CCCCCEEECCCCCCH	12.94	19764811
178	Phosphorylation	GKYYPLKSMTEKEQQ CEEECCCCCCHHHHH	38.32	19764811
180	Phosphorylation	YYPLKSMTEKEQQQL EECCCCCCHHHHHHH	51.50	22673903
199	Phosphorylation	FLFDKPVSPLLLASG CCCCCCCHHHHHHHC	20.54	22496350
215	Methylation	ARDWPDARGIWHNDN CCCCCCCCCCEECCC	44.50	-
224	Phosphorylation	IWHNDNKSFLVWVNE CEECCCCCEEEEECH	30.02	26437602
247	Acetylation	MEKGGNMKEVFRRFC EECCCCHHHHHHHHH	55.51	156255
265	Acetylation	QKIEEIFKKAGHPFM HHHHHHHHHCCCCCC	47.58	7923447
279	Phosphorylation	MWNQHLGYVLTCPSN CCCCCCEEEEECCCC	9.92	-
285	Phosphorylation	GYVLTCPSNLGTGLR EEEEECCCCCCCCCC	47.00	26437602
303	Phosphorylation	HVKLAHLSKHPKFEE EEEEHHHHCCCCHHH	21.03	26437602
313	Phosphorylation	PKFEEILTRLRLQKR CCHHHHHHHHHHHHC	33.06	19764811
322	Phosphorylation	LRLQKRGTGGVDTAA HHHHHCCCCCCCCCC	34.49	19764811
327	Phosphorylation	RGTGGVDTAAVGSVF CCCCCCCCCCEECEE	17.70	19764811
332	Phosphorylation	VDTAAVGSVFDVSNA CCCCCEECEEECCCC	17.01	19764811
337	Phosphorylation	VGSVFDVSNADRLGS EECEEECCCCCCCCC	28.30	22210691
365	Acetylation	KLMVEMEKKLEKGQS HHHHHHHHHHHCCCC	62.44	19863011
372	Phosphorylation	KKLEKGQSIDDMIPA HHHHCCCCHHHCCCC	36.33	22777824

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
-	K	Ubiquitination	E3 ubiquitin ligase	TRIM63	Q969Q1	PMID:18222470

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of KCRM_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of KCRM_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
TRI63_HUMAN	TRIM63	physical	18222470
ASB9_HUMAN	ASB9	physical	25416956
VATC2_HUMAN	ATP6V1C2	physical	26186194
PALM2_HUMAN	PALM2	physical	26186194
ABCB7_HUMAN	ABCB7	physical	26344197
ASB9_HUMAN	ASB9	physical	21516116
VATC2_HUMAN	ATP6V1C2	physical	28514442
PALM2_HUMAN	PALM2	physical	28514442

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• DB00148: Creatine