VATC2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATC2_HUMAN
• UniProt AC: Q8NEY4
• Protein Name: V-type proton ATPase subunit C 2
• Gene Name: ATP6V1C2
• Organism: Homo sapiens (Human).
• Sequence Length: 427
• Protein Description: Subunit of the peripheral V1 complex of vacuolar ATPase. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
• Protein Sequence: MSEFWLISAPGDKENLQALERMNTVTSKSNLSYNTKFAIPDFKVGTLDSLVGLSDELGKLDTFAESLIRRMAQSVVEVMEDSKGKVQEHLLANGVDLTSFVTHFEWDMAKYPVKQPLVSVVDTIAKQLAQIEMDLKSRTAAYNTLKTNLENLEKKSMGNLFTRTLSDIVSKEDFVLDSEYLVTLLVIVPKPNYSQWQKTYESLSDMVVPRSTKLITEDKEGGLFTVTLFRKVIEDFKTKAKENKFTVREFYYDEKEIEREREEMARLLSDKKQQYQTSCVALKKGSSTFPDHKVKVTPLGNPDRPAAGQTDRERESEGEGEGPLLRWLKVNFSEAFIAWIHIKALRVFVESVLRYGLPVNFQAVLLQPHKKSSTKRLREVLNSVFRHLDEVAATSILDASVEIPGLQLNNQDYFPYVYFHIDLSLLD

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
33	Phosphorylation	TSKSNLSYNTKFAIP CCCCCCCCCCCCCCC	29.98	-
49	Phosphorylation	FKVGTLDSLVGLSDE CCCCCHHHHCCCCHH	28.24	28270605
54	Phosphorylation	LDSLVGLSDELGKLD HHHHCCCCHHHCCHH	24.10	28270605
74	Phosphorylation	LIRRMAQSVVEVMED HHHHHHHHHHHHHHC	20.70	29759185
82	Phosphorylation	VVEVMEDSKGKVQEH HHHHHHCCCCHHHHH	29.96	29759185
83	Acetylation	VEVMEDSKGKVQEHL HHHHHCCCCHHHHHH	75.07	69321
142	Phosphorylation	LKSRTAAYNTLKTNL HHHCHHHHHHHHHHH	13.25	26033855
144	Phosphorylation	SRTAAYNTLKTNLEN HCHHHHHHHHHHHHH	19.56	26033855
156	Phosphorylation	LENLEKKSMGNLFTR HHHHHHHHHHHHHHH	42.88	21712546
162	Phosphorylation	KSMGNLFTRTLSDIV HHHHHHHHHHHHHHC	26.38	22210691
164	Phosphorylation	MGNLFTRTLSDIVSK HHHHHHHHHHHHCCC	27.79	22210691
166	Phosphorylation	NLFTRTLSDIVSKED HHHHHHHHHHCCCCC	25.36	27251275
286	Phosphorylation	CVALKKGSSTFPDHK HEEEECCCCCCCCCC	34.78	28348404
287	Phosphorylation	VALKKGSSTFPDHKV EEEECCCCCCCCCCE	42.61	28348404
288	Phosphorylation	ALKKGSSTFPDHKVK EEECCCCCCCCCCEE	40.67	28348404
383	Phosphorylation	RLREVLNSVFRHLDE HHHHHHHHHHHHHHH	20.62	28857561

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATC2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATC2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATC2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
STK24_HUMAN	STK24	physical	26186194
VATE2_HUMAN	ATP6V1E2	physical	26186194
VATE1_HUMAN	ATP6V1E1	physical	26186194
POTEF_HUMAN	POTEF	physical	26186194
VATA_HUMAN	ATP6V1A	physical	26186194
VATC1_HUMAN	ATP6V1C1	physical	26186194
DMXL1_HUMAN	DMXL1	physical	26186194
VATD_HUMAN	ATP6V1D	physical	26186194
VATB2_HUMAN	ATP6V1B2	physical	26186194
VATF_HUMAN	ATP6V1F	physical	26186194
VATG1_HUMAN	ATP6V1G1	physical	26186194
VATG2_HUMAN	ATP6V1G2	physical	26186194
HECD1_HUMAN	HECTD1	physical	26186194
WASF1_HUMAN	WASF1	physical	26186194
PDC10_HUMAN	PDCD10	physical	26186194
NIPA_HUMAN	ZC3HC1	physical	26186194
GOGA2_HUMAN	GOLGA2	physical	21516116
VATA_HUMAN	ATP6V1A	physical	26496610
VATB2_HUMAN	ATP6V1B2	physical	26496610
MAGA2_HUMAN	MAGEA2	physical	26496610
VATG1_HUMAN	ATP6V1G1	physical	26496610
ECSIT_HUMAN	ECSIT	physical	26496610
RT09_HUMAN	MRPS9	physical	26496610
TTC9C_HUMAN	TTC9C	physical	26496610
VATE2_HUMAN	ATP6V1E2	physical	28514442
VATD_HUMAN	ATP6V1D	physical	28514442
VATG2_HUMAN	ATP6V1G2	physical	28514442
VATE1_HUMAN	ATP6V1E1	physical	28514442
VATC1_HUMAN	ATP6V1C1	physical	28514442
VATF_HUMAN	ATP6V1F	physical	28514442
VATB2_HUMAN	ATP6V1B2	physical	28514442
VATA_HUMAN	ATP6V1A	physical	28514442
DMXL1_HUMAN	DMXL1	physical	28514442
PDC10_HUMAN	PDCD10	physical	28514442
POTEF_HUMAN	POTEF	physical	28514442
WASF1_HUMAN	WASF1	physical	28514442
NIPA_HUMAN	ZC3HC1	physical	28514442
STK24_HUMAN	STK24	physical	28514442
VATG1_HUMAN	ATP6V1G1	physical	28514442

Drug and Disease Associations

• Kegg Drug
• DrugBank
• There are no disease associations of PTM sites.