dbPTM

VATG2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

Overview of Protein Modification Sites with Functional and Structural Information
UniProt ID	VATG2_HUMAN
UniProt AC	O95670
Protein Name	V-type proton ATPase subunit G 2
Gene Name	ATP6V1G2
Organism	Homo sapiens (Human).
Sequence Length	118
Subcellular Localization	Melanosome . Highly enriched in late-stage melanosomes.
Protein Description	Catalytic subunit of the peripheral V1 complex of vacuolar ATPase (V-ATPase). V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells..
Protein Sequence	MASQSQGIQQLLQAEKRAAEKVADARKRKARRLKQAKEEAQMEVEQYRREREHEFQSKQQAAMGSQGNLSAEVEQATRRQVQGMQSSQQRNRERVLAQLLGMVCDVRPQVHPNYRISA

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
3	Phosphorylation	-----MASQSQGIQQ -----CCHHHHHHHH	29.12	25159151
5	Phosphorylation	---MASQSQGIQQLL ---CCHHHHHHHHHH	28.07	29507054
16	Ubiquitination	QQLLQAEKRAAEKVA HHHHHHHHHHHHHHH	50.80	-
16	2-Hydroxyisobutyrylation	QQLLQAEKRAAEKVA HHHHHHHHHHHHHHH	50.80	-
47	Phosphorylation	AQMEVEQYRREREHE HHHHHHHHHHHHHHH	9.72	-
57	Phosphorylation	EREHEFQSKQQAAMG HHHHHHHHHHHHHHC	37.44	24719451
65	Phosphorylation	KQQAAMGSQGNLSAE HHHHHHCCCCCHHHH	23.10	21406692
70	Phosphorylation	MGSQGNLSAEVEQAT HCCCCCHHHHHHHHH	26.78	24719451
77	Phosphorylation	SAEVEQATRRQVQGM HHHHHHHHHHHHHHH	26.53	21406692

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Modified Location	Modified Residue	Modification	Type of Upstream Proteins	Gene Name of Upstream Proteins	UniProt AC of Upstream Proteins	Sources
Oops, there are no upstream regulatory protein records of VATG2_HUMAN !!

Functions of PTM Sites

Modified Location	Modified Residue	Modification	Function	Reference
Oops, there are no descriptions of PTM sites of VATG2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Modified Location	Modification	Variant Position (Distance <= 10)	Residue Change	SAP	Related Disease	Reference
Oops, there are no SNP-PTM records of VATG2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference	Domain-Domain Interactions
VATE1_HUMAN	ATP6V1E1	physical	14667819

Drug and Disease Associations

Kegg Drug
DrugBank
There are no disease associations of PTM sites.

Regulatory Network of VATG2_HUMAN

Related Literatures of Post-Translational Modification