VATE2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: VATE2_HUMAN
• UniProt AC: Q96A05
• Protein Name: V-type proton ATPase subunit E 2
• Gene Name: ATP6V1E2
• Organism: Homo sapiens (Human).
• Sequence Length: 226
• Protein Description: Subunit of the peripheral V1 complex of vacuolar ATPase essential for assembly or catalytic function. V-ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. This isoform is essential for energy coupling involved in acidification of acrosome (By similarity)..
• Protein Sequence: MALSDVDVKKQIKHMMAFIEQEANEKAEEIDAKAEEEFNIEKGRLVQTQRLKIMEYYEKKEKQIEQQKKILMSTMRNQARLKVLRARNDLISDLLSEAKLRLSRIVEDPEVYQGLLDKLVLQGLLRLLEPVMIVRCRPQDLLLVEAAVQKAIPEYMTISQKHVEVQIDKEAYLAVNAAGGVEVYSGNQRIKVSNTLESRLDLSAKQKMPEIRMALFGANTNRKFFI

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
4	Phosphorylation	----MALSDVDVKKQ ----CCCCHHHHHHH	26.50	29255136
10	Ubiquitination	LSDVDVKKQIKHMMA CCHHHHHHHHHHHHH	58.04	-
33	2-Hydroxyisobutyrylation	KAEEIDAKAEEEFNI HHHHHHHHHHHHHCC	53.21	-
42	2-Hydroxyisobutyrylation	EEEFNIEKGRLVQTQ HHHHCCCCCCCEEHH	45.60	-
42	Ubiquitination	EEEFNIEKGRLVQTQ HHHHCCCCCCCEEHH	45.60	21906983
52	Acetylation	LVQTQRLKIMEYYEK CEEHHHHHHHHHHHH	42.04	178226061
56	Phosphorylation	QRLKIMEYYEKKEKQ HHHHHHHHHHHHHHH	10.27	24927040
57	Phosphorylation	RLKIMEYYEKKEKQI HHHHHHHHHHHHHHH	14.15	25884760
59	Ubiquitination	KIMEYYEKKEKQIEQ HHHHHHHHHHHHHHH	50.54	-
59	2-Hydroxyisobutyrylation	KIMEYYEKKEKQIEQ HHHHHHHHHHHHHHH	50.54	-
73	Phosphorylation	QQKKILMSTMRNQAR HHHHHHHHHHHHHHH	18.66	-
74	Phosphorylation	QKKILMSTMRNQARL HHHHHHHHHHHHHHH	13.24	-
96	Phosphorylation	DLISDLLSEAKLRLS HHHHHHHHHHHHHHH	42.69	23403867
191	Acetylation	YSGNQRIKVSNTLES ECCCCEEEEECCHHH	41.63	-
191	Ubiquitination	YSGNQRIKVSNTLES ECCCCEEEEECCHHH	41.63	-
195	Phosphorylation	QRIKVSNTLESRLDL CEEEEECCHHHHHCC	25.13	23403867
198	Phosphorylation	KVSNTLESRLDLSAK EEECCHHHHHCCCHH	41.05	23403867
203	Phosphorylation	LESRLDLSAKQKMPE HHHHHCCCHHHHCHH	32.84	23403867

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of VATE2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of VATE2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of VATE2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
VATG1_HUMAN	ATP6V1G1	physical	21516116

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.

Related Literatures of Post-Translational Modification

Phosphorylation

"Global survey of phosphotyrosine signaling identifies oncogenickinases in lung cancer.";
Rikova K., Guo A., Zeng Q., Possemato A., Yu J., Haack H., Nardone J.,Lee K., Reeves C., Li Y., Hu Y., Tan Z., Stokes M., Sullivan L.,Mitchell J., Wetzel R., Macneill J., Ren J.M., Yuan J.,Bakalarski C.E., Villen J., Kornhauser J.M., Smith B., Li D., Zhou X.,Gygi S.P., Gu T.-L., Polakiewicz R.D., Rush J., Comb M.J.;
Cell 131:1190-1203(2007).
Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-56, AND MASSSPECTROMETRY.
PubMed: 18083107