MAGA2_HUMAN - PTM Information in dbPTM

Basic Information of Protein

• UniProt ID: MAGA2_HUMAN
• UniProt AC: P43356
• Protein Name: Melanoma-associated antigen 2
• Gene Name: MAGEA2
• Organism: Homo sapiens (Human).
• Sequence Length: 314
• Subcellular Localization: Nucleus. Nucleus, PML body.
• Protein Description: Reduces p53/TP53 transactivation function through recruitment of HDAC3 to p53/TP53 transcription sites. Also represses p73/TP73 activity. Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination by TRIM28 potentially in presence of Ubl-conjugating enzyme UBE2H. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May play a role in embryonal development and tumor transformation or aspects of tumor progression. In vitro promotes cell viability in melanoma cell lines. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Negatively regulates acetylation and sumoylation of PML and represses PML-induced p53/TP53 acetylation and activation..
• Protein Sequence: MPLEQRSQHCKPEEGLEARGEALGLVGAQAPATEEQQTASSSSTLVEVTLGEVPAADSPSPPHSPQGASSFSTTINYTLWRQSDEGSSNQEEEGPRMFPDLESEFQAAISRKMVELVHFLLLKYRAREPVTKAEMLESVLRNCQDFFPVIFSKASEYLQLVFGIEVVEVVPISHLYILVTCLGLSYDGLLGDNQVMPKTGLLIIVLAIIAIEGDCAPEEKIWEELSMLEVFEGREDSVFAHPRKLLMQDLVQENYLEYRQVPGSDPACYEFLWGPRALIETSYVKVLHHTLKIGGEPHISYPPLHERALREGEE

Overview of Protein Modification Sites with Functional and Structural Information

Experimental Post-Translational Modification Sites

* ASA = Accessible Surface Area

Locations	Modification	Substrate Peptides & Secondary Structure	ASA (%)	Reference
7	Phosphorylation	-MPLEQRSQHCKPEE -CCHHHHHHCCCHHH	24.78	26434776
11	Sumoylation	EQRSQHCKPEEGLEA HHHHHCCCHHHHHHH	54.03	-
11	Sumoylation	EQRSQHCKPEEGLEA HHHHHCCCHHHHHHH	54.03	-
64	Phosphorylation	DSPSPPHSPQGASSF CCCCCCCCCCCCCCC	25.37	-
124	Phosphorylation	VHFLLLKYRAREPVT HHHHHHHHHCCCCCC	14.96	-
131	Phosphorylation	YRAREPVTKAEMLES HHCCCCCCHHHHHHH	34.94	20068231
132	Ubiquitination	RAREPVTKAEMLESV HCCCCCCHHHHHHHH	42.45	21906983
138	Phosphorylation	TKAEMLESVLRNCQD CHHHHHHHHHHHCHH	23.61	20068231
152	Phosphorylation	DFFPVIFSKASEYLQ HHHHHHHHCHHHHHH	19.05	24719451
244	Ubiquitination	SVFAHPRKLLMQDLV CCCCCHHHHHHHHHH	50.88	21906983
255	Phosphorylation	QDLVQENYLEYRQVP HHHHHHCCHHHCCCC	10.52	24043423
258	Phosphorylation	VQENYLEYRQVPGSD HHHCCHHHCCCCCCC	12.07	24043423

Upstream regulatory proteins (kinases for phosphorylation sites, E3 ubiquitin ligases of ubiquitination sites, ...)

Oops, there are no upstream regulatory protein records of MAGA2_HUMAN !!

Functions of PTM Sites

Oops, there are no descriptions of PTM sites of MAGA2_HUMAN !!

Disease-associated PTM Sites based on SAP

* Distance = the distance between SAP position and PTM sites.

Oops, there are no SNP-PTM records of MAGA2_HUMAN !!

Protein-Protein Interaction

Interacting Protein	Gene Name	Interaction Type	PPI Reference
HDAC3_HUMAN	HDAC3	physical	16847267
TIF1B_HUMAN	TRIM28	physical	20864041
PML_HUMAN	PML	physical	22117195
MDM2_HUMAN	MDM2	physical	26001071
P53_HUMAN	TP53	physical	26468294

Drug and Disease Associations

• Kegg Disease
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• OMIM Disease
• There are no disease associations of PTM sites.
• Kegg Drug
• There are no disease associations of PTM sites.
• There are no disease associations of PTM sites.
• DrugBank
• There are no disease associations of PTM sites.